Dr. Julian Ambrus Jr. Medicine Associate Professor of Medicine Buffalo General Hospital 100 High Street Buffalo NY, 14203 Phone: (716) 859-2985 Fax: (716) 859-2999 Email: JAMBRUS@BUFFALO.EDU View map

OFFICE LOCATIONS

Buffalo General Hospital - Kaleida Health Rheumatology Clinic 100 High Street Buffalo NY, 14203 Phone: 716-859-2985 Fax: 716-859-2999 Contact: Tracey Roth Hours: Tuesdays PM View map
UBMD Internal Medicine 3980 Sheridan Drive Amherst NY, 14226 Phone: 716-882-6544 Fax: 716-882-6833 Contact: Jill Balbuzoski Hours: Mondays PM View map	Insurance Accepted Blue Cross & Blue Shield of WNY Inc CIGNA HealthCare Community Blue (HMO) Community Blue Advantage Empire Fidelis GHI Independent Health Association (HMO) Medicare NYS Medicaid North American Administrators Nova Preferred Care Railroad Medicare United Healthcare Univera Health Care (HMO)

DESCRIPTION OF INTERESTS

My research revolves around IL-14 and its role in immunological memory. Studies delve into 3 areas - vaccination, autoimmunity and lymphoid malignancies.

SPECIALTIES

Allergy and Immunology

EDUCATION

1979	Doctor of Medicine, Medicine Jefferson Medical College
1975	Bachelor of Arts, Molecular Biophysics and Biochemistry Yale University

PUBLICATIONS

Shen L, Suresh L, Li H, Zhang C, Kumar V, Pankewycz O, Ambrus JL; IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans.; Clin Immunol; 2009 Mar; 130(3); 304-312

Ford RJ, Shen L, Lin-Lee YC, Pham LV, Multani A, Zhou HJ, Tamayo AT, Zhang C, Hawthorn L, Cowell JK, Ambrus JL; Development of a murine model for blastoid variant mantle-cell lymphoma.; Blood; 2007 Jun; 109(11); 4899-4906

Ludwig LB, Ambrus JL, Krawczyk KA, Sharma S, Brooks S, Hsiao CB, Schwartz SA; Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products.; Retrovirology; 2006 Nov; 3; 80-80

Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL; Development of autoimmunity in IL-14alpha-transgenic mice.; J Immunol; 2006 Oct; 177(8); 5676-5686

Carone DA, Benedict RH, Zivadinov R, Singh B, Ambrus JL; Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder.; J Neuroimaging; 2006 Apr; 16(2); 163-166

Shen L, Zhang C, Ambrus JL, Wang JH; Silencing of human c-myc oncogene expression by poly-DNP-RNA.; Oligonucleotides; 2005 Jan; 15(1); 23-35

Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL; Interferons and interferon inhibitory activity in disease and therapy.; Exp Biol Med (Maywood); 2004 Apr; 229(4); 285-290

Shucard JL, Parrish J, Shucard DW, McCabe DC, Benedict RH, Ambrus J; Working memory and processing speed deficits in systemic lupus erythematosus as measured by the paced auditory serial addition test.; J Int Neuropsychol Soc; 2004 Jan; 10(1); 35-45

Ambrus JL, Dembinski W, Ambrus JL, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC; Free interferon-alpha/beta receptors in the circulation of patients with adenocarcinoma.; Cancer; 2003 Dec; 98(12); 2730-2733

Raghavendran K, Thompson B, Kulaylat MN, Ambrus J; The Adult Respiratory Syndrome; Journal of Medicine; 2003;

Tullis RH, Duffin RP, Zech M, Ambrus JL; Affinity hemodialysis for antiviral therapy. I. Removal of HIV-1 from cell culture supernatants, plasma, and blood.; Ther Apher; 2002 Jun; 6(3); 213-220

Kandeel A, Zeid M, Helm T, Lillie MA, Donahue E and Ambrus Jr JL; Evaluation of chronic urticaria in patients with hashimoto thyroiditis; Journal of Clinical Immunology; 2001 Oct; 21; 337

Kandeel AA, Zeid M, Helm T, Lillie MA, Donahue E, Ambrus JL; Evaluation of chronic urticaria in patients with Hashimoto thyroiditis.; J Clin Immunol; 2001 Sep; 21(5); 335-347

Ambrus CM, Anthone S, Stadler A, Cameron MS, Wells K, Stadler I, Ambrus JL; Treatment of lead poisoning with an immobilized chelator comparison with conventional therapy.; Res Commun Mol Pathol Pharmacol; 2001 Jan; 110(3-4); 253-263

Kandeel A, Ramesh S, Chen Y, Celik C, Jenis E, Ambrus JL; Microscopic polyangiitis in a pediatric patient.; Arch Fam Med; 2000 Nov; 9(10); 1189-1192

Ambrus CM, Lajos TZ, Stadler I, Stadler A, Alfano J, Tulumello JA, Ambrus JL; Myocardial release of non-transferrin-bound iron during cardio-pulmonary bypass surgery.; J Med; 1999 Jan; 30(3-4); 157-167

Ambrus CM, Stadler I, Toumbis CA, Stadler A, Anthone S, Anthone R, DeAlarcon P, Deshpande G, Conway J, Vladutiu AO, Ambrus JL; Removal of non-transferrin-bound iron from blood with iron overload using a device with immobilized desferrioxamine.; J Med; 1999 Jan; 30(3-4); 211-224

Ambrus JL, Sridhar NR; Immunologic aspects of renal disease.; JAMA; 1997 Dec; 278(22); 1938-1945

Ambrus JL, Ambrus JL, Chadha S, Novick D, Rubinstein M, Gopalakrishnan B, Bernstein Z, Priore RL, Chadha KC; Mechanism(S) of interferon inhibitory activity in blood from patients with AIDS and patients with lupus erythematosus with vasculitis.; Res Commun Mol Pathol Pharmacol; 1997 Jun; 96(3); 255-265

Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford R; Identification of a cDNA for a human high molecular-weight B-cell growth factor.; Proc Natl Acad Sci U S A; 1996 Jul; 93(15); 8154-8154

Ambrus JULIAN, Contractor V, Joseph A, Long J, Blumenthal D; A Potential Role for PGE and IL-14 (HMW-BCGF) in B-Cell Hyperactivity of Patients with Systemic Lupus Erythematosus.; Am J Ther; 1995 Dec; 2(12); 933-942

Ford R, Tamayo A, Martin B, Niu K, Claypool K, Cabanillas F, Ambrus J; Identification of B-cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas.; Blood; 1995 Jul; 86(1); 283-293

Pippin J, Contractor V, Ambrus JL; An inexpensive method for the rapid identification of specific cDNAs from cDNA libraries.; Biotechniques; 1994 Apr; 16(4); 676-678

Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ; Identification of a cDNA for a human high-molecular-weight B-cell growth factor.; Proc Natl Acad Sci U S A; 1993 Jul; 90(13); 6330-6334

Levy E, Ambrus J, Kahl L, Molina H, Tung K, Holers VM; T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE).; Clin Exp Immunol; 1992 Nov; 90(2); 235-244

Ford RJ, Tamayo A, Ambrus JL; The role of growth factors in human lymphomas.; Curr Top Microbiol Immunol; 1992 Jan; 182; 341-347

Ambrus JL, Haneiwich S, Chesky L, McFarland P, Engler RJ; Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen).; J Allergy Clin Immunol; 1991 Nov; 88(5); 775-783

Ambrus JL, Haneiwich S, Chesky L, McFarland P, Peters MG, Engler RJ; Abnormal response to a human B cell growth factor in patients with common variable immunodeficiency (CVI).; J Allergy Clin Immunol; 1991 Jun; 87(6); 1138-1149

Young KR, Ambrus JL, Malbran A, Fauci AS, Tenner AJ; Complement subcomponent C1q stimulates Ig production by human B lymphocytes.; J Immunol; 1991 May; 146(10); 3356-3364

Ambrus JL, Chesky L, McFarland P, Young KR, Mostowski H, August A, Chused TM; Induction of proliferation by high molecular weight B cell growth factor or low molecular weight B cell growth factor is associated with increases in intracellular calcium in different subpopulations of human B lymphocytes.; Cell Immunol; 1991 May; 134(2); 314-324

Ambrus JL, Chadha KC, Ambrus JL; Interferon inhibitors.; Ann Intern Med; 1991 Apr; 114(7); 606-607

Ambrus JL, Chesky L, Chused T, Young KR, McFarland P, August A, Brown EJ; Intracellular signaling events associated with the induction of proliferation of normal human B lymphocytes by two different antigenically related human B cell growth factors (high molecular weight B cell growth factor (HMW-BCGF) and the complement facto; J Biol Chem; 1991 Feb; 266(6); 3702-3708

Chadha KC, Ambrus JL, Stadler I, Ambrus JL; Interferon inhibitor in the blood of patients with systemic lupus erythematosus.; J Biol Regul Homeost Agents; 1991 Jan; 5(1); 1-9

Ambrus JL, Chesky L, Stephany D, McFarland P, Mostowski H, Fauci AS; Functional studies examining the subpopulation of human B lymphocytes responding to high molecular weight B cell growth factor.; J Immunol; 1990 Dec; 145(12); 3949-3955

Goldstein H, Koerholz D, Chesky L, Fan XD, Ambrus JL; Divergent activities of protein kinases in IL-6-induced differentiation of a human B cell line.; J Immunol; 1990 Aug; 145(3); 952-961

Ambrus JL, Peters MG, Fauci AS, Brown EJ; The Ba fragment of complement factor B inhibits human B lymphocyte proliferation.; J Immunol; 1990 Mar; 144(5); 1549-1553

Begley CG, Burton JD, Tsudo M, Brownstein BH, Ambrus JL, Waldmann TA; Human B lymphocytes express the p75 component of the interleukin 2 receptor.; Leuk Res; 1990 Jan; 14(3); 263-271

Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF, Meijer S, van der Giessen M, van der Hem GK, The TH; Association between active Wegener's granulomatosis and anticytoplasmic antibodies.; Arch Intern Med; 1989 Nov; 149(11); 2461-2465

Uckun FM, Fauci AS, Chandan-Langlie M, Myers DE, Ambrus JL; Detection and characterization of human high molecular weight B cell growth factor receptors on leukemic B cells in chronic lymphocytic leukemia.; J Clin Invest; 1989 Nov; 84(5); 1595-1608

Uckun FM, Myers DE, Fauci AS, Chandan-Langlie M, Ambrus JL; Leukemic B-cell precursors constitutively express functional receptors for human interleukin-1.; Blood; 1989 Aug; 74(2); 761-776

Lewis RA, Rankin JA, Allison AC, Ambrus JL; Regulated generation of leukotrienes in mononuclear cells.; Adv Prostaglandin Thromboxane Leukot Res; 1989 Jan; 19; 495-498

Peters MG, Ambrus JL, Fauci AS, Brown EJ; The Bb fragment of complement factor B acts as a B cell growth factor.; J Exp Med; 1988 Oct; 168(4); 1225-1235

Ambrus JL, Ambrus JL, Chadha KC; Interferon inhibition in lupus erythematosus.; N Engl J Med; 1988 Sep; 319(9); 582-583

Ambrus JL, Jurgensen CH, Brown EJ, McFarland P, Fauci AS; Identification of a receptor for high molecular weight human B cell growth factor.; J Immunol; 1988 Aug; 141(3); 861-869

Ambrus JL, Jurgensen CH, Witzel NL, Lewis RA, Butler JL, Fauci AS; Leukotriene C4 produced by a human T-T hybridoma suppresses Ig production by human lymphocytes.; J Immunol; 1988 Apr; 140(7); 2382-2388

Uckun FM, Jaszcz W, Ambrus JL, Fauci AS, Gajl-Peczalska K, Song CW, Wick MR, Myers DE, Waddick K, Ledbetter JA; Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.; Blood; 1988 Jan; 71(1); 13-29

Nakagawa T, Nakagawa N, Ambrus JL, Fauci AS; Differential effects of interleukin 2 vs B cell growth factor on human B cells.; J Immunol; 1988 Jan; 140(2); 465-469

Uckun FM, Fauci AS, Heerema NA, Song CW, Mehta SR, Gajl-Peczalska K, Chandan M, Ambrus JL; B-cell growth factor receptor expression and B-cell growth factor response of leukemic B cell precursors and B lineage lymphoid progenitor cells.; Blood; 1987 Oct; 70(4); 1020-1034

Goldstein H, Ambrus JL, Grove JH, Margolick JB, Fauci AS; Functional and biochemical characterization of B-cell differentiation factor (BCDF) produced by an HTLV-I-transformed human T-cell clone and demonstration of specific binding of the factor to a BCDF responsive cell line.; Cell Immunol; 1987 Sep; 108(2); 343-355

Osur SL, Lillie MA, Chen PB, Ambrus JL, Wilson ME; Elevation of serum IgG levels and normalization of T4/T8 ratio after hepatitis in a patient with common variable hypogammaglobulinemia.; J Allergy Clin Immunol; 1987 Jun; 79(6); 969-975

Ambrus CM, Anthone S, Horvath C, Kalghatgi K, Lele AS, Eapen G, Ambrus JL, Ryan AJ, Li P; Extracorporeal enzyme reactors for depletion of phenylalanine in phenylketonuria.; Ann Intern Med; 1987 Apr; 106(4); 531-537

Nakagawa N, Nakagawa T, Volkman DJ, Ambrus JL, Fauci AS; The role of interleukin 2 in inducing Ig production in a pokeweed mitogen-stimulated mononuclear cell system.; J Immunol; 1987 Feb; 138(3); 795-801

Ambrus JL, Jurgensen CH, Bowen DL, Tomita S, Nakagawa T, Nakagawa N, Goldstein H, Witzel NL, Mostowski HS, Fauci AS; The activation, proliferation, and differentiation of human B lymphocytes.; Adv Exp Med Biol; 1987 Jan; 213; 163-175

Peters M, Ambrus JL, Zheleznyak A, Walling D, Hoofnagle JH; Effect of interferon-alpha on immunoglobulin synthesis by human B cells.; J Immunol; 1986 Nov; 137(10); 3153-3157

Jurgensen CH, Ambrus JL, Fauci AS; Production of B cell growth factor by normal human B cells.; J Immunol; 1986 Jun; 136(12); 4542-4547

Bowen DL, Ambrus JL, Fauci AS; Identification and characterization of a B cell activation factor (BCAF) produced by a human T cell line.; J Immunol; 1986 Mar; 136(6); 2158-2163

Margolick JB, Ambrus JL, Volkman DJ, Fauci AS; Human T4+ lymphocytes produce a phagocytosis-inducing factor (PIF) distinct from interferon-alpha and interferon-gamma.; J Immunol; 1986 Jan; 136(2); 546-554

Ambrus JL, Jurgensen CH, Brown EJ, Fauci AS; Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor.; J Exp Med; 1985 Oct; 162(4); 1319-1335

Goldstein H, Volkman DJ, Ambrus JL, Fauci AS; Characterization of a T4+/Leu-8+ T cell clone that directly helps B cell Ig production by secreting B cell differentiation factor.; J Immunol; 1985 Jul; 135(1); 339-343

Tomita S, Ambrus JL, Volkman DJ, Longo DL, Mitsuya H, Reitz MS, Fauci AS; Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation.; J Exp Med; 1985 Jul; 162(1); 393-398

Ambrus JL, Fauci AS; Human B lymphoma cell line producing B cell growth factor.; J Clin Invest; 1985 Feb; 75(2); 732-739

Butler JL, Ambrus JL, Fauci AS; Characterization of monoclonal B cell growth factor (BCGF) produced by a human T-T hybridoma.; J Immunol; 1984 Jul; 133(1); 251-255

Ambrus JL, Fauci AS; Diffuse histiocytic lymphoma in a patient treated with cyclophosphamide for Wegener's granulomatosis.; Am J Med; 1984 Apr; 76(4); 745-747

Kehrl JH, Muraguchi A, Falkoff RJ, Ambrus JL, Butler JL, Fauci AS; Activation and immunoregulation of human B lymphocytes.; Uremia Invest; 1984 Jan; 8(3-4); 157-166

Bielat KL, Halpern J, Simich JP, Huben RP, Ambrus JL; A morphological analysis of an in vitro model of cytotoxic antitumor activity.; Cancer Detect Prev; 12(1-6); 1-7

Halpern J, Joy JV, Bielat KL, Ambrus JL; Human peripheral blood mononuclear cells (PBM's) cultured in serum free medium (II): Lymphocyte-macrophage interaction and related morphological changes.; J Med; 16(4); 461-482

Halpern J, Bielat KL, Simich JP, Klein E, Ambrus JL; Human peripheral blood mononuclear cells (PBM) cultured in serum-free medium. III. Morphological study of an in vitro microcytotoxicity model.; J Med; 17(3-4); 201-218

Halpern J, Islam A, Simich JP, Piver MS, Ambrus JL, Bielat KL; Tumor-infiltrating lymphocytes: in vitro characterization of morphological and phenotypical changes.; Cancer Detect Prev; 13(1); 1-7

Halpern JN, Bielat KL, Simich JP, Ambrus JL; Ultrastructural descriptions of interactions between tumor-infiltrating lymphocytes and tumor cells in an in vitro model of culture in serum-free medium.; Cancer Detect Prev; 13(3-4); 213-223

Sayyid SH, Bielat KL, Mahafzah MM, Ambrus JL; Ultrastructural study of a murine model for Chediak Higashi syndrome.; J Med; 22(6); 339-354

GRANTS

November 2003 to October 2004 Analysis of the Potential Role of the Ets-1 Transcription Factor in Systemic Lupus Erythematosus IRCAF fund from SUNT-Buffalo Lee Sinha, Julian Ambrus $40,000

September 2001 to July 2006 Community Based Research on Autoimmune Disease and Asthma National Institute of Environmental Health Sciences John Vena Carlos Crespo Laurene Tumiel Julian Ambrus $1,607,795

January 1998 to December 2001 Western New York Autoimmune Disease Center Oishei Foundation Julian Ambrus $530,724

January 1997 to December 1998 Evaluation of immunologic tolerance in solid organ transplantation Julian Ambrus $20,000

January 1997 to December 1998 Molecular markers of transplant rejection Buffalo General Hospital Foundation Grant Julian Ambrus

January 1996 to December 2000 Analysis of IL-14 production by a Burkitt lymphoma cell line Troupe Foundation Julian Ambrus $100,000

January 1993 to December 1996 Structural analysis of HMW-BCGF NIH Julian Ambrus $284,452

January 1992 Regulation of intracellular calcium during the induction of human B cell proliferation Arthritis Foundation - Eastern Missouri Chapter Julian Ambrus $30,000

January 1991 to December 1993 Characterization of a unique protein in common variable immunodeficiency sera March of Dimes Birth Defects Foundation Julian Ambrus $50,000

January 1991 to December 1993 Role of eicosanoids in normal and SLE B cell function GD Searle and Company Julian Ambrus $161,500

January 1990 to December 1993 Cloning of a receptor regulating growth of memory B cells Monsanto Julian Ambrus $228,310