|
|
|
OFFICE LOCATIONS
VA Western New York Healthcare System
3495 Bailey Avenue
Buffalo NY, 14215
Phone: 862-6529
Fax: 862-6526
Contact: Cookie Thurston
Email: berenson@acsu.buffalo.edu
 View map |
Insurance Accepted
Veterans Administration |
DESCRIPTION OF INTERESTS
Immunoregulatory roles of macrophage gangliosides.
Role of alveolar macrophages in the pathogenesis of COPD
Haemophilus influenzae adherence
Research interests of this laboratory focus on two key areas. Our first area of interest concentrates on the immunologic roles of mammalian macrophage gangliosides. Gangliosides are sialylated glycosphingolipids that hold diverse immunoregulatory roles as receptors and as mediators of cellular differentiation in many eukaryotic cells. Our studies have encompassed ganglioside regulation of macrophage cytokine production, ganglioside-associated membrane architectural alterations in HIV-infected macrophages, and the receptor roles of macrophage gangliosides for bacterial pathogens. This work will lead to better understanding of mechanisms of macrophage activation, to ultimately permit manipulation of host immune cellular responses.
Our second area of interest centers on the immunomodulation of inflammatory responses of human alveolar macrophages by specific antigens of nontypeable Haemophilus influenzae, contributing to the pathogenesis of COPD. Studies encompass defining the repertoire of inflammatory mediators of human alveolar and blood-derived macrophages, modulated by antigens of Haemophilus influenzae and characterizing NTHI-regulated functional and phenotypic immunologic properties of macrophages, in patients with COPD compared with normal subjects. These investigations into fundamental mechanisms of the inflammatory responses of immune cells and their contribution to COPD will provide the basis for designing novel and more effective therapies. |
SPECIALTIES
EDUCATION
| 1987 |
Infectious Diseases, Yale University
|
| 1983 |
Residency, University of Michigan
|
| 1980 |
Medical School, University at Buffalo, State University of New York
|
PUBLICATIONS
| Berenson CS, Maloney J., Grove L., Wrona C., Sethi S; Impaired Alveolar Macrophage Response to Haemophilus Antigens in Chronic Obstructive Lung Disease.; Journal of Respiratory and Critical Care Medicine; 2006 Mar; 174(1); 31-40 |
| Tomilo DL, Smith PF, Ogundele AB, DiFrancesco R, Berenson CS, Eberhardt E, Bednarczyk E, Morse GD; Inhibition of atazanavir oral absorption by lansoprazole gastric acid suppressionin healthy volunteers.; Pharmacotherapy; 2006 Mar; 26(3); 341-346 |
| Sethi S, Maloney J., Grove L., Wronta C.T., Berenson CS; Airway inflammation and bronchial bacterial colonization in ex-smokers with COPD.; American Journal of Respiratory and Critical Care Medicine; 2006; 173(9); 991-998 |
| Berenson CS, Garlipp M.A., Grove L.L., Maloney J., Sethi S; Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease.; Journal of Infectious Disease; 2006; 194(10); 1375-1384 |
| Berenson CS, Murphy TF, Wrona, C.T., Sethi S; Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage cytokines; Infection and Immunity; 2005; 73(5); 2728-2735 |
| Smith PF, Bullock JM, Booker BM, Haas CE, Berenson CS, Jusko WJ; The influence of St. John‘s wort on the pharmacokinetics and protein bindingof imatinib mesylate.; Pharmacotherapy; 2004 Nov; 24(11); 1508-1514 |
| Smith PF, Bullock JM, Booker BM, Haas CE, Berenson CS, Jusko WJ; The influence of St. Johns wort on the pharmacokinetics and protein bindingof imatinib mesylate; Pharmacotherapy; 2004 Nov; 24(11); 1508-1514 |
| Smith PF, Kearney BP, Liaw S, Cloen D, Bullock JM, Haas CE, Yale K, Booker BM, Berenson CS, Coakley DF, Flaherty JF; Effect of tenofovir disoproxil fumarate on the pharmacokinetics and pharmacodynamicsof total, R-, and S-methadone; Pharmacotherapy; 2004 Aug; 24(8); 970-977 |
| Smith PF, Kearney BP, Liaw S, Cloen D, Bullock JM, Haas CE, Yale K, Booker BM, Berenson CS, Coakley DF, Flaherty JF; Effect of tenofovir disoproxil fumarate on the pharmacokinetics and pharmacodynamicsof total, R-, and S-methadone.; Pharmacotherapy; 2004 Aug; 24(8); 970-977 |
| Smith PF, Bullock JM, Booker BM, Haas CE, Berenson CS, Jusko WJ; Induction of imatinib metabolism by hypericum perforatum.; Blood; 2004 Aug; 104(4); 1229-1230 |
| Shelton MJ, Cloen D, DiFrancesco R, Berenson CS, Esch A, de Caprariis PJ, Palic B, Schur JL, Buggé CJ, Ljungqvist A, Espinosa O, Hewitt RG; The effects of once-daily saquinavir/minidose ritonavir on the pharmacokinetics
of methadone.; J Clin Pharmacol; 2004 Mar; 44(3); 293-304 |
| Shelton MJ, Cloen D, DiFrancesco R, Berenson CS, Esch A, de Caprariis PJ, Palic B, Schur JL, Buggé CJ, Ljungqvist A, Espinosa O, Hewitt RG; The effects of once-daily saquinavir/minidose ritonavir on the pharmacokinetics of methadone.; J Clin Pharmacol; 2004 Mar; 44(3); 293-304 |
| Shelton MJ, Giovanniello AA, Cloen D, Berenson CS, Keil K, DiFrancesco R, Hewitt RG; Effects of didanosine formulations on the pharmacokinetics of amprenavir.; Pharmacotherapy; 2003 Jul; 23(7); 835-842 |
| Berenson C, Sayles KB, Ye S, Reinhold BB, Reinhold VN, Yohe HC; A conserved ceramide motif present in murine and human mononuclear cell glycosphingolipids; Journal of Lipid Research; 2003; |
| BERENSON CS; Preferential binding of ganglioside-adherent nontypeable Haeomphilus influenzae to neolacto core structures of respiratory (HEp-2) cells.; Infection and Immunity; 2003; |
| BERENSON CS; The role of ceramide of human macrophage gangliosides in activation of human macrophages.; Journal of Leukocyte Biology; 2002; 72; 492-502 |
| BERENSON CS; Differences in splenic B lymphocyte ganglioside expression and accessibility in normal and endotoxin-hyporesponsive mice.; Journal of Leukocyte Biology; 2001; 69; 969-976 |
| BERENSON CS; The major glycolipids of human peripheral blood monocytes/macrophages; absence of ganglio series structures.; Glycobiology; 2001; 11; 831-841 |
| Farooqui MA, Berenson C, Lohr JW; Mycobacterium marinum infection in a renal transplant recipient.; Transplantation; 1999 Jun; 67(11); 1495-1496 |
| Fakih MG, Murphy TF, Pattoli MA, Berenson CS; Specific binding of Haemophilus influenzae to minor gangliosides of human respiratory epithelial cells.; Infect Immun; 1997 May; 65(5); 1695-1700 |
| Berenson CS, Patterson MA, Pattoli MA, Murphy TF; A monoclonal antibody to human macrophage gangliosides inhibits macrophage migration.; J Leukoc Biol; 1996 Mar; 59(3); 371-379 |
| Smith PF, Haas CE, Booker BM, Berenson CS, Jusko WJ; The Influence of St. John’s Wort on the Pharmacokinetics and Protein Binding of Imatinib Mesylate; Journal of Clinical Oncology; |
|
|
|
|
|
|
|
