Dr. Peter Bradford
Pharmacology And Toxicology
Associate Professor
126 Farber Hall
Department of Pharmacology & Toxicology
University at Buffalo 3435 Main Street
Buffalo NY, 14214
Phone: (716) 829-2110
Fax: 716-829-2801
Email: pgb@buffalo.edu

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DESCRIPTION OF INTERESTS

I am an Associate Professor in the Department of Pharmacology & Toxicology of the School of Medicine and Biomedical Sciences. I have a secondary appointment as Adjunct Associate Professor in the Department of Oral Biology in the School of Dental Medicine.


SPECIALTIES

Endocrinology, Diabetes and Metabolism
Reproductive Endocrinology
Endocrinology
Molecular genetics
Regulation of gene expression
Signal Transduction


EDUCATION

1982 Doctor of Philosophy, Biochemistry
University of Rochester
1980 Master of Science, Biochemistry
University of Rochester
1977 Bachelor of Science, Biology and Chemistry
State University of New York at Albany
Summa Cum Laude
Phi Beta Kappa, Beta Beta Beta


EXPERTISE

HLA Genetic Analysis
Laboratory analysis of HLA genotypes in realtionship to disease susceptibility. Mandatory concurrent genetic counseling is provided.


PUBLICATIONS

Bradford PG; Anticancer properties of phytosterols; Natural Products and Cancer Chemoprevention; 2007;
Bradford PG; Beta-sitosterol activates Fas-mediated apoptosis in breast cancer cells; Phytomedicine; 2007;
Bradford PG; Estrogens prevent osteoblast apoptosis; Healthy Aging; 2007;
Bradford PG; Phytoestrogens activate estrogen receptor 1and estrogenic responses in human breast and bone cancer cell lines; Molecular Nutrition & Food Research; 2007; 51; 171-177
Bradford PG Awad AB; Phytosterols as anticancer compounds; Molecular Nutrition & Food Research; 2007; 51; 161-170
Bradford PG; The Blackboard Learning System; Journal of Educational Technology Systems; 2007; 35(3); 301-314
Bradford PG; Nutrition and Cancer Prevention; ; 2006;
Bradford PG; Phytosterols: Bioactivity on Cancer; Nutrition and Cancer Prevention; 2006;
Bradford PG; Targeting ceramide to stimulate apoptosis by dietary means; Current Topics in Nutraceutical Research; 2004; 2; 93-100
Bradford PG, Maglich JM, Kirkwood KL; IL-1 beta increases type 1 inositol trisphosphate receptor expression and IL-6 secretory capacity in osteoblastic cell cultures.; Mol Cell Biol Res Commun; 2000 Feb; 3(2); 73-75
Bradford PG, Maglich JM, Ponticelli AS, Kirkwood KL; The effect of bone morphogenetic protein-7 on the expression of type I inositol 1,4,5-trisphosphate receptor in G-292 osteosarcoma cells and primary osteoblast cultures.; Arch Oral Biol; 2000 Feb; 45(2); 159-166
Kirkwood KL, Golub LM, Bradford PG; Non-antimicrobial and antimicrobial tetracyclines inhibit IL-6 expression in murine osteoblasts.; Ann N Y Acad Sci; 1999 Jun; 878; 667-670
Lee B, Bradford PG, Laychock SG; Characterization of inositol 1,4,5-trisphosphate receptor isoform mRNA expression and regulation in rat pancreatic islets, RINm5F cells and betaHC9 cells.; J Mol Endocrinol; 1998 Aug; 21(1); 31-39
Kirkwood KL, Homick K, Dragon MB, Bradford PG; Cloning and characterization of the type I inositol 1,4,5-trisphosphate receptor gene promoter. Regulation by 17beta-estradiol in osteoblasts.; J Biol Chem; 1997 Sep; 272(36); 22425-22431
Hui P, Guo X, Bradford PG; Isolation and functional characterization of the human gene encoding the myeloid zinc finger protein MZF-1.; Biochemistry; 1995 Dec; 34(50); 16493-16502
Bradford PG, Jin Y, Hui P; 1,25-dihydroxyvitamin D3 enhances the transcription and expression of the inositol trisphosphate receptor gene in HL-60 cells.; Mol Pharmacol; 1993 Aug; 44(2); 292-297
Bradford PG, Wang X, Jin Y, Hui P; Transcriptional regulation and increased functional expression of the inositol trisphosphate receptor in retinoic acid-treated HL-60 cells.; J Biol Chem; 1992 Oct; 267(29); 20959-20964
Bradford PG, Jin Y, Hui P, Wang X; IL-3 and GM-CSF induce the expression of the inositol trisphosphate receptor in K562 myeloblast cells.; Biochem Biophys Res Commun; 1992 Aug; 187(1); 438-442
Bradford PG, Autieri M; Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic acid or dimethyl sulphoxide.; Biochem J; 1991 Nov; 280 (; 205-210
Bradford PG, Irvine RF; Specific binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate on membranes of HL-60 cells.; Biochem Biophys Res Commun; 1987 Dec; 149(2); 680-685
Bitar KN, Bradford PG, Putney JW, Makhlouf GM; Stoichiometry of contraction and Ca2+ mobilization by inositol 1,4,5-trisphosphate in isolated gastric smooth muscle cells.; J Biol Chem; 1986 Dec; 261(35); 16591-16596
Bradford PG, Rubin RP; Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils.; J Biol Chem; 1986 Nov; 261(33); 15644-15647
Bradford PG, Rubin RP; Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations.; Biochem J; 1986 Oct; 239(1); 97-102
Spät A, Bradford PG, McKinney JS, Rubin RP, Putney JW; A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils.; Nature; 1986; 319; 514
Bradford PG, Rubin RP; Pertussis toxin inhibits chemotactic factor-induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils.; FEBS Lett; 1985 Apr; 183(2); 317-320
Bradford PG, Rubin RP; Characterization of formylmethionyl-leucyl-phenylalanine stimulation of inositol trisphosphate accumulation in rabbit neutrophils.; Mol Pharmacol; 1985 Jan; 27(1); 74-78
Bradford PG, Marinetti GV, Abood LG; Stimulation of phospholipase A2 and secretion of catecholamines from brain synaptosomes by potassium and A23187.; J Neurochem; 1983 Dec; 41(6); 1684-1693
Bradford PG, Rubin RP; Leukotriene B4 stimulates phospholipase-C-mediated formation of inositol trisphosphate in neutrophils: implications for convergence of the phospholipase A2 and C pathways.; Adv Prostaglandin Thromboxane Leukot Res 15: 105-108, 1985;
Bradford PG, Rubin RP; The differential effects of nedocromil sodium and sodium cromoglycate on the secretory response of rabbit peritoneal neutrophils.; Eur J Respir Dis 69: Suppl 147) 238-240, 1986;


GRANTS

January 2002 to January 2003
Estrogen Control of InsP3 Receptor Expression in Bone
Peter Bradford
$1,170,400
April 2000
HLA Genotyping, Allelic Determination, and Genetic Counseling
Multiple corporate sponsors
Peter Bradford
$12,000
March 2000 to August 2002
HLA Genotypes Associated with Susceptibility to Chronic Beryllium Disease
Environment and Society Institute
Peter Bradford
$16,000
October 1997 to September 2000
Estrogen Regulation of the Osteoblast InsP3 Receptor
NIDCR
Peter Bradford
$156,000

Dietary Phytosterols and Vascular Smooth Muscle Cells
Atif Awad, PhD Peter Bradford, PhD
$1,366,300



 
Dr. Peter Bradford
Dr. Peter Bradford