Dr. John Canty Medicine 345 Biomedical Research Building Buffalo NY, 14214 Phone: 829-2663 View map

OFFICE LOCATIONS

UBMD Internal Medicine 3980 Sheridan Dr. 6th Floor Amherst NY, 14226 Phone: 716-882-6544 Fax: 716-882-6833 Hours: 8am-4:30pm View map	Insurance Accepted Aetna U.S. Healthcare Better Health Plan, Inc. (HMO) Community Blue (HMO) Empire Fidelis GHI Independent Health Association (HMO) United Healthcare Univera Health Care (HMO)
University at Buffalo Biomedical Research Bldg. Rm 345 3435 Main Street Buffalo NY, 14214 Phone: (716)829-2495 Fax: (716)829-2665 View map

DESCRIPTION OF INTERESTS

My main area of expertise is medicine.

SPECIALTIES

Cardiology

EDUCATION

1979	Doctor of Medicine, Medicine University of New York at Buffalo Thesis Honors
1975	Bachelor of Science, Biomedical Engineering Rensselaer Polytechnic Institute Cum Laude

PUBLICATIONS

Canty JM; test; test; 2006 May; 205(1142); 224-229

Banas, M.D. Young, H. Fallavollita, J.A. Canty, J.M., Jr.; Persistent reductions in flow and function after revascularization of swine with hibernating myocardium.; Journal of the American College of Cardiology; 2006;

Fallavollita JA Luisi, Jr., A.J. Michalek, S.M. Valverde, A.M. deKemp, R.A. Haka, M.S. Hutson, A.D. Canty, Jr., J.M.; Prediction of Arrhythmic Events with Positron Emission Tomography: PAREPET study design and methods; Contemp Clin Trials; 2006;

Suzuki, G. Lee, T.C. Fallavollita, J.A. Canty, J.M., Jr.; Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle.; Circulation Research; 2005; 96; 767-775

Gangasani, A. Sidhu, S. Fallavollita, J.A. Korotchkina, L. G. Suzuki, G. Patel, M.S. Canty, J.M., Jr.; Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy.; Circulation; 2005; 112(II); II-21-II-22

Luisi AJ Fallavollita, J.A. Luisi, A.J. Valverde, A.M. Michalek, S.M. Heavey, B.M. Canty, J.M.; Electrocardiographic risk stratification of sudden cardiac death.; J Electrocardiol; 2005; 35(4S); 140-140

Canty, J. M. Fallavollita, J. A.; Hibernating myocardium; J Nucl Cardiol; 2005; 12(1); 104-119

Fallavollita, J.A. Riegel, B.J. Suzuki, G. Valeti, U. Canty, J.M., Jr.; Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy; American Journal of Physiology - Heart & Circulatory Physiology; 2005; 289; H2688-H2696

Luisi AJ Canty, J.M., Jr. deKemp, R.A. Haka, M.S. Toorongian, S.A. Fallavollita, J.A.; Patients with ischemic cardiomyopathy eligible for ICD therapy demonstrate extensive sympathetic denervation out of proportion to previous infarction.; Circulation; 2005; 112; 472-472

Canty JM, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA; Hibernating Myocardium. Chronically Adapted to Ischemia but Vulnerable to Sudden Death.; Circ Res; 2004 Mar;

Canty JM Jr, Suzuki G, Banas MD, Verheyen F, Borgers M, Fallavollita JA; Hibernating myocardium: Chronically adapted to ischemia but vulnerable to sudden death; Circulation Research; 2004; 194(8); 1142-1149

Thijssen VL, Borgers M, Lenders MH, Ramaekers FC, Suzuki G, Palka B, Fallavollita JA, Thomas SA, Canty JM Jr; Temporal and Spatial Variations in Structural Protein Expression During the Progression From Stunned to Hibernating Myocardium; Circulation; 2004; 110(21); 2213-2221

Canty JM, Fallavollita JA; Sympathetic nerves and myocyte necrosis: more than meets the eye.; Circ Res; 2003 Oct; 93(9); 796-798

Bett GC, Kathuria S, Szigeti GP, Rasmusson RL, Fallavollita JA, Canty JM; Contractile properties of normal and hibernating pig cardiac myocytes; Proceedings Biomedical Engineering in NY, Alfred University; 2003;

Fallavollita JA, Malm BJ, Canty JM; Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest.; Circ Res; 2003 Jan; 92(1); 48-55

Iyer VS Young,R.F. Lee,T.C. Nowak,N. Canty,J.M.,Jr.; Microarray analysis of differential gene expression in hibernating myocardium is consistent with regional remodeling and local neurohumoral activation; FASEB J; 2003; 17(4); A530-A530

Iyer VS Canty,J.M.,Jr.; Regional reductions in b-adrenergic receptor mediated cAMP prpoduction and reciprocal alterations in Ga protein expression in swine with hibernating myocardium; FASEB J; 2003; 17(4); A843-A843

Malm BJ, Suzuki G, Canty JM, Fallavollita JA; Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation.; Cardiovasc Res; 2002 Dec; 56(3); 422-432

Thomas SA, Fallavollita JA, Suzuki G, Borgers M, Canty JM; Dissociation of regional adaptations to ischemia and global myolysis in an accelerated Swine model of chronic hibernating myocardium.; Circ Res; 2002 Nov; 91(10); 970-977

Luisi AJ, Fallavollita JA, Suzuki G, Canty JM; Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium.; Circulation; 2002 Aug; 106(7); 779-781

Fallavollita JA, Logue M, Canty JM; Coronary patency and its relation to contractile reserve in hibernating myocardium.; Cardiovasc Res; 2002 Jul; 55(1); 131-140

Canty JM, Suzuki G; Heterogeneity of apoptosis and myolysis in coronary microembolization: a competition between programmed cell death and programmed cell survival.; Eur Heart J; 2002 Jun; 23(11); 838-840

Fallavollita JA, Canty JM; Ischemic cardiomyopathy in pigs with two-vessel occlusion and viable, chronically dysfunctional myocardium.; Am J Physiol Heart Circ Physiol; 2002 Apr; 282(4); 1370-1379

Canty JM, Lee TC; Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don>t.; J Mol Cell Cardiol; 2002 Apr; 34(4); 375-377

Canty JM Jr, Suzuki G; Heterogeneity of apoptosis and myolysis in coronary microembolization: A competition between programmed cell death and programmed cell survival; European Heart Journal; 2002; 23(11); 838-840

Luisi AJ Fallavollita,J.A. Suzuki,G. Canty,J.M.,Jr.; Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium; Circulation; 2002; 106(7); 779-781

Canty JM Jr & Lee TC; Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don‘t; J. Mol. Cell. Cardiol.; 2002 Jan; 34; 375-377

Malm BJ, Suzuki G, Canty JM Jr; Variability of Contractile Reserve in Hibernating Myocardium: Dependence on the Method of Inotropic Stimulation; Cardiovascular Research; 2002; 56(3); 422-432

Fallavollita JA, Lim H, Canty JM; Myocyte apoptosis and reduced SR gene expression precede the transition from chronically stunned to hibernating myocardium.; J Mol Cell Cardiol; 2001 Nov; 33(11); 1937-1944

Canty JM, Fallavollita JA; Lessons from experimental models of hibernating myocardium.; Coron Artery Dis; 2001 Aug; 12(5); 371-380

Dube S, Canty JM; Shear stress-induced vasodilation in porcine coronary conduit arteries is independent of nitric oxide release.; Am J Physiol Heart Circ Physiol; 2001 Jun; 280(6); 2581-2590

Fallavollita JA, Logue M, Canty JM; Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve.; J Am Coll Cardiol; 2001 Jun; 37(7); 1989-1995

Feng J, Schaus BJ, Fallavollita JA, Lee TC, Canty JM; Preload induces troponin I degradation independently of myocardial ischemia.; Circulation; 2001 Apr; 103(16); 2035-2037

Feng J, Schaus BJ, Fallavollita JA, Lee TC & Canty JM Jr; Preload induces troponin degradation independently of myocardial ischemia; Circ. Res.; 2001 Jan; 103; 2035-2037

Kositprapa C, Zhang B, Berger S, Canty JM, Lee TC; Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes.; Mol Cell Biochem; 2000 Nov; 214(1-2); 47-55

Canty JM; Nitric oxide and short-term hibernation: friend or foe?; Circ Res; 2000 Jul; 87(2); 85-87

Fallavollita JA, Trojan C, Canty JM; Transmural distribution of FDG uptake in stunned myocardium.; Am J Physiol Heart Circ Physiol; 2000 Jul; 279(1); 102-109

Kositprapa C, Zhang B, Berger S, Canty JM Jr. & Lee TC; Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes; Mol. Cell. Biochem.; 2000 Jan; 214; 47-55

Canty JM, Fallavollita JA; Chronic hibernation and chronic stunning: a continuum.; J Nucl Cardiol; 2000; 7(5); 509-527

Lim H, Fallavollita JA, Hard R, Kerr CW, Canty JM; Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium.; Circulation; 1999 Dec; 100(23); 2380-2386

Fallavollita JA, Jacob S, Young RF, Canty JM; Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium.; Am J Physiol; 1999 Oct; 277(4 Pt); 1418-1428

Thomas SA, Fallavollita JA, Lee TC, Feng J, Canty JM; Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine.; Circ Res; 1999 Sep; 85(5); 446-456

Canty JM, Fallavollita JA; Resting myocardial flow in hibernating myocardium: validating animal models of human pathophysiology.; Am J Physiol; 1999 Jul; 277(1 Pt); 417-422

Fallavollita JA, Canty JM; Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs.; Circulation; 1999 Jun; 99(21); 2798-2805

Thomas SA, Fallavollita JA, Lee TC, Feng J & Canty JM Jr; Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression following reversible ischemia in swine; Circ. Res.; 1999 Jan; 85; 446-456

Fallavollita JA, Perry BJ, Canty JM; 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium.; Circulation; 1997 Apr; 95(7); 1900-1909

Fallavollita JA, Kumar K, Brody AS, Bunnell IL, Canty JM; Detection of coronary artery calcium to differentiate patients with early coronary atherosclerosis from luminally normal arteries.; Am J Cardiol; 1996 Dec; 78(11); 1281-1284

Canty JM, Smith TP; Modulation of coronary autoregulatory responses by endothelium-derived nitric oxide.; Int J Cardiol; 1995 Jul; 50(3); 207-215

Canty JM, Smith TP; Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state.; Circ Res; 1995 Jun; 76(6); 1079-1087

Rajagopalan S, Dube S, Canty JM; Regulation of coronary diameter by myogenic mechanisms in arterial microvessels greater than 100 microns in diameter.; Am J Physiol; 1995 Feb; 268(2 Pt); 788-793

Canty JM, Fallavollita JA; Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis.; Basic Res Cardiol; 1995 Jan; 90(1); 5-8

Fallavollita JA, Brody AS, Bunnell IL, Kumar K, Canty JM; Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old.; Circulation; 1994 Jan; 89(1); 285-290

Canty JM, Schwartz JS; Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs.; Circulation; 1994 Jan; 89(1); 375-384

Canty JM; Measurement of myocardial perfusion by fast computed tomography.; Am J Card Imaging; 1993 Dec; 7(4); 309-316

Canty JM; Methods of assessing coronary blood flow and flow reserve.; Am J Card Imaging; 1993 Sep; 7(3); 222-232

Satoh S, Klocke FJ, Canty JM; Tone-dependent coronary arterial-venous pressure differences at the cessation of venous outflow during long diastoles.; Circulation; 1993 Sep; 88(3); 1238-1244

Smith TP, Canty JM; Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs.; Circ Res; 1993 Aug; 73(2); 232-240

Grant BJ, Canty JM, Srinivasan G, Brody AS; Pulmonary arterial elasticity in awake dogs.; J Appl Physiol; 1993 Aug; 75(2); 840-848

Canty JM, Judd RM, Brody AS, Klocke FJ; First-pass entry of nonionic contrast agent into the myocardial extravascular space. Effects on radiographic estimates of transit time and blood volume.; Circulation; 1991 Nov; 84(5); 2071-2078

Farhi ER, Canty JM, Klocke FJ; Dissociation of diastolic pressure-segment length and pressure-wall thickness relations during vasodilation in the conscious dog.; J Am Coll Cardiol; 1991 Sep; 18(3); 850-857

Farhi ER, Klocke FJ, Mates RE, Kumar K, Judd RM, Canty JM, Satoh S, Sekovski B; Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts.; Circ Res; 1991 Feb; 68(2); 392-401

Canty JM, Giglia J, Kandath D; Effect of tachycardia on regional function and transmural myocardial perfusion during graded coronary pressure reduction in conscious dogs.; Circulation; 1990 Nov; 82(5); 1815-1825

Canty JM, Brooks A; Phasic volumetric coronary venous outflow patterns in conscious dogs.; Am J Physiol; 1990 May; 258(5 Pt); 1457-1463

Farhi ER, Canty JM, Klocke FJ; Effects of graded reductions in coronary perfusion pressure on the diastolic pressure-segment length relation and the rate of isovolumic relaxation in the resting conscious dog.; Circulation; 1989 Nov; 80(5); 1458-1468

Grant BJ, Canty JM; Effect of cardiac output on pulmonary hemodynamics.; Respir Physiol; 1989 Jun; 76(3); 303-317

Canty JM; Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog.; Circ Res; 1988 Oct; 63(4); 821-836

Canty JM, Klocke FJ; Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure.; Circ Res; 1987 Nov; 61(5 Pt); 107-116

Klocke FJ, Ellis AK, Canty JM; Interpretation of changes in coronary flow that accompany pharmacologic interventions.; Circulation; 1987 Jun; 75(6 Pt); 34-38

Grant BJB and JM Canty, Jr.; Pulmonary arterial pressure-diameter relations in awake dogs.; Circulation; 1987 May; 76(IV); 469

Canty JM, Klocke FJ, Mates RE; Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters.; Circ Res; 1987 Feb; 60(2); 273-282

CANTY JM; Klocke, F. J., R. E. Mates, J. M. Canty, Jr. and A. K. Ellis. Current controversies concerning coronary pressure-flow relationships. In: Simulation and Control of the Cardiac System. S. Sideman and R. Beyar, editors.; CRC Press; 1987 Jan;

CANTY JM; Mates, R. E., F. J. Klocke and J. M. Canty, Jr. Impedance to coronary flow. In: Activation, Metabolism and Perfusion of the Heart. S. Sideman and R. Bayer, editors.; Martinus Nijhoff Publishers, Dordrecht (Netherlands); 1987 Jan;

Klocke FJ, Canty JM, Arani DT, Krawczyk JA; Adjustments in regional coronary perfusion accompanying reductions in regional coronary arterial pressure.; Can J Cardiol; 1986 Jul; Suppl; 200-204

Canty JM, Klocke FJ, Mates RE; Pressure and tone dependence of coronary diastolic input impedance and capacitance.; Am J Physiol; 1985 May; 248(5 Pt); 700-711

Klocke FJ, Mates RE, Canty JM, Ellis AK; Coronary pressure-flow relationships. Controversial issues and probable implications.; Circ Res; 1985 Mar; 56(3); 310-323

Canty JM, Klocke FJ; Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve.; Circulation; 1985 Feb; 71(2); 370-377

Aversano T, Klocke FJ, Mates RE, Canty JM; Preload-induced alterations in capacitance-free diastolic pressure-flow relationship.; Am J Physiol; 1984 Mar; 246(3 Pt); 410-417

CANTY JM; Klocke, F. J., J. M. Canty, Jr., and R. E. Mates. Evolving concepts of coronary pressure-flow relationships. In: Functional Aspects of the Normal, Hypertrophied and Failing Heart. F. L. Abel and W.H. Newman, editors.; Martinus Nijhoff Publishing; 1984 Jan;

CANTY JM; Mates, R. E., T. Burns, J. M. Canty, R. Greenberg and J. Neeson. Modeling diastolic impedance to coronary blood flow, In: Mechanics of the Coronary Circulation, p. 41-44. American Society of Mechanical Engineers, 1983.; Mechanics of the Coronary Circulation; 1983 Jan;

Canty JM, Mates RE; A programmable pressure control system for coronary flow studies.; Am J Physiol; 1982 Nov; 243(5); 796-802

Klocke FJ, Weinstein IR, Klocke JF, Ellis AK, Kraus DR, Mates RE, Canty JM, Anbar RD, Romanowski RR, Wallmeyer KW, Echt MP; Zero-flow pressures and pressure-flow relationships during single long diastoles in the canine coronary bed before and during maximum vasodilation. Limited influence of capacitive effects.; J Clin Invest; 1981 Oct; 68(4); 970-980

Mates RE, Klocke FJ, Canty JM; Coronary capacitance.; Prog Cardiovasc Dis; 31(1); 1-15

GRANTS

April 2004 to February 2009 Hibernating Myocardium and Sudden Cardiac Death,” Total Costs $3,563,287 National Heart Lung and Blood Institute John Canty

March 2003 to December 2008 “Chronic Adaptations to Myocardial Ischemia”Total Costs $2,272,332 National Heart Lung and Blood Institute John Canty

March 2003 to February 2004 High Throughput Proteomic Analysis in Health and Disease”, Total Costs $40,000 University at Buffalo Interdisciplinary Research and Creative Activities Fund John Canty

January 2003 to December 2005 Physiological, Molecular and Pathological Triggers Responsible for Cardiac Arrhythmogenesis in Viable Chronically Dysfunctional Myocardium”, Total Costs $ 141,750 Mae Stone Goode Trust John Canty

January 2003 to December 2005 Sudden Death in Ischemic Heart Disease”, Total Costs $ 1,500,000 John R. Oishei Foundation John Canty

October 2001 to September 2005 Angiogenesis and Myocardial Perfusion”, Total direct costs, $556,400 Department of Veterans Affairs John Canty

January 2000 to December 2004 Apoptosis and Contractility in Ischemic Cardiomyopathy National Heart Lung and Blood Institute John Canty

December 1999 to November 2004 Apoptosis and contractility in ischemic cardiomyopathy NIH Te-Chung Lee, John Canty

January 1999 to December 1999 Apoptosis and contractility in Ischemic Cardiomyopathy, 1999, Total Award, $19,368 VISN 2 Research Incentive Award John Canty

January 1997 to December 1997 Three-Dimensional Mapping of Electrophysiology and Regional Function to Identify Viable Dysfunctional Myocardium, $39,926, 1997 Biosense, Inc. John Canty

August 1996 to July 2002 Chronic Adaptations to Myocardial Ischemia, Total Costs $1,605,769 National Heart Lung and Blood Institute John Canty

July 1996 to June 2001 Chronic adaptations to myocardial ischemia NIH Te-Chung Lee, John Canty

January 1994 to December 1999 Endothelium-Dependent Control of Coronary Flow, Direct Costs $606,600, 1994 – 1999; 40% effort Veterans Affairs Merit Review John Canty

January 1993 to December 1996 Endothelial-Dependent Modulation of Coronary Autoregulatory Responses, $132,000, 1993 – 1996 American Heart Association (National) John Canty

January 1987 to December 1993 Coronary Circulatory Control and Pathophysiology, Principal Investigator, Francis J. Klocke, $2,448,976, 1987 – 1993 National Heart Lung and Blood Institute John Canty

January 1987 to December 1990 Modulation of Coronary Autoregulatory Responses, $417,489, 1987 – 1990 (returned after 1 year and replaced by Program Project Grant) National Heart Lung and Blood Institute John Canty

January 1986 to December 1987 Modulation of Coronary Autoregulatory Responses, $99,000, 1986 – 1987 American Heart Association (National) John Canty

January 1985 to December 1986 Research Development Fund, SUNY at Buffalo, $15,000 1985-1986 John Canty

January 1983 to December 1983 Alexandrine and Alexander Sinsheimer Fund, $17,500 1983 John Canty

January 1983 to December 1988 Limitations of Coronary Autoregulatory Responses $249,804, 1983 – 1988 National Heart, Lung and Blood Institute John Canty

January 1983 to December 1986 Limitations of Coronary Autoregulatory Responses, $71,300, 1983 – 1986 John Canty

January 1982 to December 1982 John C. Sable Fund, $12,000 1982 John Canty