Dr. Stanley Halvorsen
Pharmacology And Toxicology
102 Farber Hall
Buffalo NY, 14214
Phone: (716) 829-2651
Email: stanh@buffalo.edu

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OFFICE LOCATIONS

Office Location
207 Sherman Hall
Buffalo NY, 14214

Phone: 829-2651
Fax: 829-2801
Email: stanh@buffalo.edu
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UB South Campus
211 Sherman Hall
Dept. Pharmacology & Toxicology
Buffalo NY, 14214

Phone: (716) 829-2651
Fax: (716) 829-2801
Contact: Stan Halvorsen
Email: stanh@buffalo.edu
View map


SPECIALTIES

Molecular and Cellular Biology
Neurobiology
Neurodegenerative disorders
Regulation of transcription and translation
Signal Transduction


EDUCATION

1989 Postdoctoral Fellow, Neurobiology
Univ. California - San Diego
1984 Ph.D., Pharmacology
University of Washington
1976 B. Pharmacy, Pharmacy
Washington State University
Cum Laude
Rho Chi Society


EXPERTISE

Cell Biology
Intracellular trafficking of STATs; nuclear translocation; oxidative stress; mitochondria dysfunction;
Molecular Neurobiology
Signaling mechanisms; transciptional regulation; immediate early genes; Ach esterase;
Molecular Signaling and Signal Transduction
Jak/STAT signaling; MAP kinase; ERK; Oxidative stress
Nerve and Growth Factors
ciliary neurotrophic factor; interferons; interleukins; neurodegenerative diseases
Neuropharmacology
Synaptic development; cholinergic synapses; neurotrophic factor effects; cholinergic differentiation
Oxidative stress
Impact of oxidative stress and free radicals on signal transduction and disease in the nervous system; mitochondria
Receptor Pharmacology
CNTF receptors; Jak/STAT coupled receptors; Nicotinic acetylcholine receptors; gp130 cytokine receptors ;


PUBLICATIONS

Monroe RK, Halvorsen SW, Halvorsen S; Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.; Neurotoxicology; 2009 Jul; 30(4); 589-598
Monroe RK, Halvorsen SW,; Mercury Abolishes Neurotrophic Factor-Stimulated Jak-STAT Signaling in NerveCells by Oxidative Stress.; Toxicol Sci; 2006 Nov; 94(1); 129-138
Monroe RK, Halvorsen SW,; Cadmium blocks receptor-mediated Jak/STAT signaling in neurons by oxidativestress.; Free Radic Biol Med; 2006 Aug; 41(3); 493-502
Halvorsen S Kaur, N; CNTF and Related Neurokines; Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition,; 2006;
Kaur N, Lu B, Monroe RK, Ward SM, Halvorsen SW,; Inducers of oxidative stress block ciliary neurotrophic factor activation ofJak/STAT signaling in neurons.; J Neurochem; 2005 Mar; 92(6); 1521-1530
Kapoor R, Kaur N, Nishanth ET, Halvorsen SW, Bergey EJ, Prasad PN, Halvorsen S; Detection of trophic factor activated signaling molecules in cells by a compactfiber-optic sensor.; Biosens Bioelectron; 2004 Sep; 20(2); 345-349
Kaur N, Kim IJ, Higgins D, Halvorsen SW; Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines.; J Neurochem; 2003 Oct; 87(2); 437-447
Jiao J, Kaur N, Lu B, Reeves SA, Halvorsen SW; Initiation and maintenance of CNTF-Jak/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors.; Brain Res Mol Brain Res; 2003 Aug; 116(1-2); 135-146
Kaur, N., Wohlhueter, A.L., Halvorsen S; Activation and inactivation of signal transducers and activators of transcription by ciliary neurotrophic factor in neuroblastoma cells; Cellular Signalling; 2002 Apr; 14; 419-429
Halvorsen S; Book Review of: The RBI Handbook of Receptor Classification and Signal Transduction; Pharmaceutical News; 2001; 8; 60-61
Halvorsen S; Book Review of: Structure-function Analysis of G-Protein-Coupled Receptors; Pharmaceutical News; 2000; 7; 45
Malek RL, Halvorsen SW; Ciliary neurotrophic factor and phorbol ester each decrease selected STAT3 pools in neuroblastoma cells by proteasome-dependent mechanisms.; Cytokine; 1999 Mar; 11(3); 192-199
Halvorsen S; Book Review of: Identification and Expression of G-Protein-Coupled Receptors; Pharmaceutical News; 1999; 6; 29
Halvorsen S; Book Review of: The RBI Handbook of Receptor Classification and Signal Transduction; Pharmaceutical News; 1999; 6; 27-28
Koshlukova S Halvorsen S; Chick Ciliary Ganglion Neurons; The Neuron in Tissue Culture; 1999;
Wang X, Halvorsen SW; Reciprocal regulation of ciliary neurotrophic factor receptors and acetylcholine receptors during synaptogenesis in embryonic chick atria.; J Neurosci; 1998 Sep; 18(18); 7372-7380
Wang X, Halvorsen SW; Retinoic acid up-regulates ciliary neurotrophic factor receptors in cultured chick neurons and cardiomyocytes.; Neurosci Lett; 1998 Jan; 240(1); 9-12
Thomas SL, Chmelar RS, Lu C, Halvorsen SW, Nathanson NM; Tissue-specific regulation of G-protein-coupled inwardly rectifying K+ channel expression by muscarinic receptor activation in ovo.; J Biol Chem; 1997 Nov; 272(47); 29958-29962
Wishingrad MA, Koshlukova S, Halvorsen SW; Ciliary neurotrophic factor stimulates the phosphorylation of two forms of STAT3 in chick ciliary ganglion neurons.; J Biol Chem; 1997 Aug; 272(32); 19752-19757
Lu C, Halvorsen SW; Channel activators regulate ATP-sensitive potassium channel (KIR6.1) expression in chick cardiomyocytes.; FEBS Lett; 1997 Jul; 412(1); 121-125
Malek RL, Halvorsen SW; Opposing regulation of ciliary neurotrophic factor receptors on neuroblastoma cells by distinct differentiating agents.; J Neurobiol; 1997 Jan; 32(1); 81-94
Koshlukova S, Finn TP, Nishi R, Halvorsen SW; Identification of functional receptors for ciliary neurotrophic factor on chick ciliary ganglion neurons.; Neuroscience; 1996 Jun; 72(3); 821-832
Halvorsen SW, Malek R, Wang X, Jiang N; Ciliary neurotrophic factor regulates nicotinic acetylcholine receptors on human neuroblastoma cells.; Neuropharmacology; 1996 Mar; 35(3); 257-265
Halvorsen SW, Jiang N, Malek R; Regulation of nicotinic acetylcholine receptors on human neuroblastoma cells during differentiation.; Biochem Pharmacol; 1995 Nov; 50(10); 1665-1671
Lu C, Hegde P, Halvorsen SW; Regulation of glibenclamide receptors in cultured chick cardiomyocytes.; Pharmacol Res; 1995 Sep; 32(3); 149-153
Halvorsen SW, Schmid HA, McEachern AE, Berg DK; Regulation of acetylcholine receptors on chick ciliary ganglion neurons by components from the synaptic target tissue.; J Neurosci; 1991 Jul; 11(7); 2177-2186
Vijayaraghavan S, Schmid HA, Halvorsen SW, Berg DK; Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor alpha-type subunit.; J Neurosci; 1990 Oct; 10(10); 3255-3262
Halvorsen SW, Berg DK; Subunit composition of nicotinic acetylcholine receptors from chick ciliary ganglia.; J Neurosci; 1990 Jun; 10(6); 1711-1718
Schoepfer R, Halvorsen SW, Conroy WG, Whiting P, Lindstrom J; Antisera against an acetylcholine receptor alpha 3 fusion protein bind to ganglionic but not to brain nicotinic acetylcholine receptors.; FEBS Lett; 1989 Nov; 257(2); 393-399
Halvorsen SW, Berg DK; Specific down-regulation of the alpha-bungarotoxin binding component on chick autonomic neurons by ciliary neuronotrophic factor.; J Neurosci; 1989 Oct; 9(10); 3673-3680
Berg DK, Boyd RT, Halvorsen SW, Higgins LS, Jacob MH, Margiotta JF; Regulating the number and function of neuronal acetylcholine receptors.; Trends Neurosci; 1989 Jan; 12(1); 16-21
Berg DK, Halvorsen SW; Acetylcholine receptor. Genes encoding nicotinic receptor subtypes on neurons.; Nature; 1988 Aug; 334(6181); 384-385
Berg, D.K., R.T. Boyd, S.W. Halvorsen, L.S. Higgins, M.H. Jacob, J. F. Margiotta, A.E. McEachern; Regulation of neuronal acetylcholine receptors by cell-cell interactions; Nicotinic Acetylcholine Receptors in the Central Nervous System; 1988; H25; 283-297
Halvorsen SW, Berg DK; Affinity labeling of neuronal acetylcholine receptor subunits with an alpha-neurotoxin that blocks receptor function.; J Neurosci; 1987 Aug; 7(8); 2547-2555
Martin JM, Subers EM, Halvorsen SW, Nathanson NM; Functional and physical properties of chick atrial and ventricular GTP-binding proteins: relationship to muscarinic acetylcholine receptor-mediated responses.; J Pharmacol Exp Ther; 1987 Feb; 240(2); 683-688
Halvorsen SW, Berg DK; Identification of a nicotinic acetylcholine receptor on neurons using an alpha-neurotoxin that blocks receptor function.; J Neurosci; 1986 Nov; 6(11); 3405-3412
Halvorsen SW, Nathanson NM; Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development.; Biochemistry; 1984 Nov; 23(24); 5813-5821
Nathanson NM, Holttum J, Hunter DD, Halvorsen SW; Partial agonist activity of oxotremorine at muscarinic acetylcholine receptors in the embryonic chick heart.; J Pharmacol Exp Ther; 1984 May; 229(2); 455-458
Halvorsen SW, Engel B, Hunter DD, Nathanson NM; Development and regulation of cardiac muscarinic acetylcholine receptor number, function and guanyl nucleotide sensitivity.; Adv Exp Med Biol; 1983; 161; 143-158
Halvorsen SW, Nathanson NM; In vivo regulation of muscarinic acetylcholine receptor number and function in embryonic chick heart.; J Biol Chem; 1981 Aug; 256(15); 7941-7948


GRANTS


CNTF Receptors on Neurons
NIH-NINDS
Stanley Halvorsen
$526,134



 
Dr. Stanley Halvorsen
Dr. Stanley Halvorsen