Dr. Paul Knight III Anesthesiology Professor of Anesthesiology/Microbiology 245 Biomedical Research Building Buffalo NY, 14214 Phone: 829-2172 Email: pknight@buffalo.edu View map

OFFICE LOCATIONS

VA Medical Center 3495 Bailey Ave Buffalo NY, 14215 Phone: 716-829-2172 View map

SPECIALTIES

Anesthesiology

PUBLICATIONS

Spengler RN, Sud R, Knight PR, Ignatowski TA; Antinociception mediated by alpha(2)-adrenergic activation involves increasing tumor necrosis factor alpha (TNFalpha) expression and restoring TNFalpha and alpha(2)-adrenergic inhibition of norepinephrine release.; Neuropharmacology; 2007 Feb; 52(2); 576-589

Nader ND, Karamanoukian HL, Reedy RL, Salehpour F, Knight PR, Nader N; Inclusion of sevoflurane in cardioplegia reduces neutrophil activity during cardiopulmonary bypass.; J Cardiothorac Vasc Anesth; 2006 Feb; 20(1); 57-62

Nader ND, Davidson BA, Tait AR, Holm BA, Knight PR; Serine antiproteinase administration preserves innate superoxide dismutase levels after acid aspiration and hyperoxia but does not decrease lung injury.; Anesth Analg; 2005 Jul; 101(1); 213-219

Ignatowski TA, Sud R, Reynolds JL, Knight PR, Spengler RN; The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha (TNF).; Neuropharmacology; 2005 Mar; 48(3); 448-460

Manderscheid PA, Bodkin RP, Davidson BA, Jensen E, Russo TA, Knight PR; Bacterial clearance and cytokine profiles in a murine model of postsurgical nosocomial pneumonia.; Clin Diagn Lab Immunol; 2004 Jul; 11(4); 742-751

Rotta AT, Shiley KT, Davidson BA, Helinski JD, Russo TA, Knight PR; Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance.; Crit Care Med; 2004 Mar; 32(3); 747-754

Russo TA, Davidson BA, Topolnycky DM, Olson R, Morrill SA, Knight PR, Murphy PM; Human neutrophil chemotaxis is modulated by capsule and O antigen from an extraintestinal pathogenic Escherichia coli strain.; Infect Immun; 2003 Nov; 71(11); 6435-6445

Russo TA, Davidson BA, Carlino-MacDonald UB, Helinski JD, Priore RL, Knight PR; The effects of Escherichia coli capsule, O-antigen, host neutrophils, and complement in a rat model of Gram-negative pneumonia.; FEMS Microbiol Lett; 2003 Sep; 226(2); 355-361

Russo TA, Bartholomew LA, Davidson BA, Helinski JD, Carlino UB, Knight PR, Beers MF, Atochina EN, Notter RH, Holm BA; Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia.; Am J Physiol Lung Cell Mol Physiol; 2002 Sep; 283(3); 655-663

Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN; Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain.; Reg Anesth Pain Med; 2002 Jul; 27(4); 357-366

Nader ND, Ignatowski TA, Kurek CJ, Knight PR, Spengler RN; Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period.; Anesth Analg; 2001 Aug; 93(2); 363-369

Shanley TP, Davidson BA, Nader ND, Bless N, Vasi N, Ward PA, Johnson KJ, Knight PR; Role of macrophage inflammatory protein-2 in aspiration-induced lung injury.; Crit Care Med; 2000 Jul; 28(7); 2437-2444

Knight PR, Kurek C, Davidson BA, Nader ND, Patel A, Sokolowski J, Notter RH, Holm BA; Acid aspiration increases sensitivity to increased ambient oxygen concentrations.; Am J Physiol Lung Cell Mol Physiol; 2000 Jun; 278(6); 1240-1247

Russo TA, Davidson BA, Priore RL, Carlino UB, Helinski JD, Knight PR; Capsular polysaccharide and O-specific antigen divergently modulate pulmonary neutrophil influx in an Escherichia coli model of gram-negative pneumonitis in rats.; Infect Immun; 2000 May; 68(5); 2854-2862

Covey WC, Ignatowski TA, Knight PR, Spengler RN; Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain.; Brain Res; 2000 Mar; 859(1); 113-122

Nader ND, Knight PR, Davidson BA, Safaee SS, Steinhorn DM; Systemic perfluorocarbons suppress the acute lung inflammation after gastric acid aspiration in rats.; Anesth Analg; 2000 Feb; 90(2); 356-361

Ignatowski TA, Covey WC, Knight PR, Severin CM, Nickola TJ, Spengler RN; Brain-derived TNFalpha mediates neuropathic pain.; Brain Res; 1999 Sep; 841(1-2); 70-77

Nader ND, Knight PR, Bobela I, Davidson BA, Johnson KJ, Morin F; High-dose nitric oxide inhalation increases lung injury after gastric aspiration.; Anesthesiology; 1999 Sep; 91(3); 741-749

Davidson BA, Knight PR, Helinski JD, Nader ND, Shanley TP, Johnson KJ; The role of tumor necrosis factor-alpha in the pathogenesis of aspiration pneumonitis in rats.; Anesthesiology; 1999 Aug; 91(2); 486-499

Nader-Djalal N, Knight PR, Thusu K, Davidson BA, Holm BA, Johnson KJ, Dandona P; Reactive oxygen species contribute to oxygen-related lung injury after acid aspiration.; Anesth Analg; 1998 Jul; 87(1); 127-133

Nader-Djalal N, Knight PR, Bacon MF, Tait AR, Kennedy TP, Johnson KJ, Nader N; Alterations in the course of acid-induced lung injury in rats after general anesthesia: volatile anesthetics versus ketamine.; Anesth Analg; 1998 Jan; 86(1); 141-146

Nader-Djalal N, Knight PR, Davidson BA, Johnson K, Nader N; Hyperoxia exacerbates microvascular lung injury following acid aspiration.; Chest; 1997 Dec; 112(6); 1607-1614

Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN; Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain.; Reg Anesth Pain Med; 27(4); 357-366

Knight PR, Davidson BA, Nader ND, Helinski JD, Marschke CJ, Russo TA, Hutson AD, Notter RH, Holm BA; Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration.; Exp Lung Res; 30(7); 535-557

Raghavendran K, Mullan B, Manderscheid P, Davidson B, Notter R, Knight P; Role of MCP-1 in aspiration pneumonitis in mice;

GRANTS

July 2008 to June 2013 Antidepressants alleviate pain by directing alpha2-adrenergic regulation of TNFalpha National Institutes of Health Tracey Ignatowski $1,976,476

April 2001 to March 2006 Brain-derived TNF and Adrenergic Responses in Neuropathic Pain National Institutes of Health Tracey Ignatowski $1,370,058