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Dr Paul Kostyniak
Pharmacology And Toxicology
Hayes B Annex
3435 Main St. Bldg 3
Buffalo NY, 14214-3015
Phone: (716) 829-2125; 3630 x111
Fax: (716) 829-2806
Email: pjkost@buffalo.edu
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DESCRIPTION OF INTERESTS
Dr. Paul Kostyniak‘s primary research program has focused on the toxicology of heavy metals, chlorinated organics, and antidote development. His lab is studying mechanisms of xenobiotic disposition and investigating the role of exogenous nutrients in the elimination of toxic pollutants. Other ongoing projects involve the assessment of risk associated with exposure to PCB isomers found in fresh water fish; and the development and testing of antimicrobial surface coatings.
As the director of the Toxicology Research Center, Dr. Kostyniak has organized an interdisciplinary research and teaching program which applies the expertise of toxicologists, pharmacologists, chemists, acquatic biologists, biochemists, pathologists, epidemiologists, geologists and physicians to basic and applied research problems in toxicology. The Center conducts coordinated scientific inquiries into health problems created by toxic chemicals.
Dr. Kostyniak also oversees the center‘s analytical toxicology laboratory and the center‘s Atlantic OSHA Professional Education Program. |
EDUCATION
| 1976 |
Ph.D., Toxicology
University of Rochester
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| 1970 |
Bachelor of Science, Biology
St. John Fisher College
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PUBLICATIONS
| Barua R, Chi LH, Fitzpatrick R, Gillard D, Kostyniak PJ; Determination of volatile organic compounds in biological samples using headspace solid-phase microextraction and gas chromatography: toluene and styrene.; J Anal Toxicol; 2008 Jun; 32(5); 379-386 |
| Bloom MS, Buck Louis GM, Schisterman EF, Liu A, Kostyniak PJ; Maternal serum polychlorinated biphenyl concentrations across critical windows of human development.; Environ Health Perspect; 2007 Sep; 115(9); 1320-1324 |
| Chen GD, Chi LH, Kostyniak PJ, Henderson D; Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss.; Toxicol Sci; 2007 Jul; 98(1); 167-177 |
| Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR; Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.; Drug Metab Dispos; 2007 Feb; 35(2); 189-193 |
| Taylor KC, Jackson LW, Lynch CD, Kostyniak PJ, Buck Louis GM; Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio.; Environ Res; 2007 Jan; 103(1); 99-105 |
| Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL; Formulation and characterization of an experimental PCB mixture designed to
mimic human exposure from contaminated fish.; Toxicol Sci; 2005 Dec; 88(2); 400-411 |
| Louis GM, Weiner JM, Whitcomb BW, Sperrazza R, Schisterman EF, Lobdell DT, Crickard K, Greizerstein H, Kostyniak PJ; Environmental PCB exposure and risk of endometriosis.; Hum Reprod; 2005 Jan; 20(1); 279-285 |
| Kostyniak PJ; Mercury and dentistry.; Alpha Omegan; 2003 Dec; 96(4); 53-56 |
| Germaine Buck, John Vena, Hebe Greizerstein, John Weiner, Bridget McGuinness, Pauline Mendola, Paul Kostyniak, Mya Swanson, Michael Bloom, James Olson; PCB congeners and pesticides and female fecundity, New York State Angler Propective Pregnancy Study; Environmental Toxicology and Pharmacology; 2002 Aug; 12; 83-92 |
| Moysich KB, Ambrosone CB, Mendola P, Kostyniak PJ, Greizerstein HB, Vena JE, Menezes RJ, Swede H, Shields PG, Freudenheim JL; Exposures associated with serum organochlorine levels among postmenopausal women from western New York State.; Am J Ind Med; 2002 Feb; 41(2); 102-110 |
| Moysich, Kirsten, Ambrosone, Christine, Mendola, Pauline, Paul Kostyniak, Greizerstein, Heber, John Vena, Menezes, Ravi, Swede, Helen, Jo Freudenheim; Exposures associated with serum organochlorine levels among postmenopausal women from western New York State; American Journal Industrial Med; 2001 Oct; 41; 102-110 |
| Gail Willsky, Goldfine AB, Paul Kostyniak, McNeill JH, Yang LQ, Khan HR, Crans DC; Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV).; J Inorg Biochem; 2001 May; 85(1); 33-42 |
| Buck GM, John Vena, Schisterman EF, Jacek Dmochowski, Mendola P, Sever LE, Fitzgerald E, Paul Kostyniak, Greizerstein H, James Olson; Parental consumption of contaminated sport fish from Lake Ontario and predicted fecundability.; Epidemiology; 2000 Jul; 11(4); 388-393 |
| Greizerstein HB, Stinson C, Mendola P, Buck GM, Kostyniak PJ, Vena JE; Comparison of PCB congeners and pesticide levels between serum and milk from lactating women.; Environ Res; 1999 Apr; 80(3); 280-286 |
| Buck, GM, Mendola, P, John Vena, Sever, LE, Paul Kostyniak, Greizerstein, H, James Olson, Stephen, FD; Paternal Lake Ontario Fish Consumption and Risk of Conception Delay, New York State Angler Cohort; Environmental Research; 1999 Feb; 80; S13-S18 |
| Kostyniak PJ, Stinson C, Greizerstein HB, Vena J, Buck G, Mendola P; Relation of Lake Ontario fish consumption, lifetime lactation, and parity to breast milk polychlorobiphenyl and pesticide concentrations.; Environ Res; 1999 Feb; 80(2 Pt); 166-174 |
| Kostyniak PJ; Mercury as a potential hazard for the dental practitioner.; N Y State Dent J; 1998 Apr; 64(4); 40-43 |
| Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ; The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote.; J Biochem Mol Toxicol; 1998 Jan; 12(1); 41-52 |
| Greizerstein HB, Gigliotti P, Vena J, Freudenheim J, Kostyniak PJ; Standardization of a method for the routine analysis of polychlorinated biphenyl congeners and selected pesticides in human serum and milk.; J Anal Toxicol; 1997 Jun; 21(7); 558-566 |
| John Vena, Buck, GM, Paul Kostyniak, Mendola, P, Fitzgerald, E, Sever, L, Jo Freudenheim, Greizerstein, H, Zielezny, M, McReynolds, J, James Olson; The New York Angler Cohort Study: Exposure Characterization and Reproductive and Developmental Health; Toxicology and Industrial Health; 1996; 12(3/4); 327-334 |
| Zalups RK, Barfuss DW, Kostyniak PJ; Altered intrarenal accumulation of mercury in uninephrectomized rats treated with methylmercury chloride.; Toxicol Appl Pharmacol; 1992 Aug; 115(2); 174-182 |
| Aleo MD, Taub ML, Kostyniak PJ; Primary cultures of rabbit renal proximal tubule cells. III. Comparative cytotoxicity of inorganic and organic mercury.; Toxicol Appl Pharmacol; 1992 Feb; 112(2); 310-317 |
| Abbott P, Thompson AC, Ferguson EJ, Doerr JC, Tarapacki JA, Kostyniak PJ, Syracuse JA, Cartonia DM, Kristal MB; Placental opioid-enhancing factor (POEF): generalizability of effects.; Physiol Behav; 1991 Nov; 50(5); 933-940 |
| Kostyniak PJ, Nakeeb SM, Schopp EM, Maccubbin AE, John EK, Green MA, Kung HF; Acute toxicity and mutagenicity of the copper complex of pyruvaldehyde-bis (N-4-methylthiosemicarbazone), Cu-PTSM.; J Appl Toxicol; 1990 Dec; 10(6); 417-421 |
| Kostyniak PJ, Greizerstein HB, Goldstein J, Lachaal M, Reddy P, Clarkson TW, Walshe J, Cunningham E; Extracorporeal regional complexing haemodialysis treatment of acute inorganic mercury intoxication.; Hum Exp Toxicol; 1990 May; 9(3); 137-141 |
| Aleo, MD, Mary Taub, James Olson, Paul Kostyniak; Primary cultures of rabbit renal tubule cells: II. Selected phase I and phase II metabolic capacities; Toxicol In Vitro; 1990; 4; 727-733 |
| Aleo MD, Taub ML, Nickerson PA, Kostyniak PJ; Primary cultures of rabbit renal proximal tubule cells: I. Growth and biochemical characteristics.; In Vitro Cell Dev Biol; 1989 Sep; 25(9); 776-783 |
| Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Roth JA; Effect of chronic exposure to hexachlorophene on rat brain cell specific marker enzymes.; Neurotoxicology; 1989 Jun; 10(2); 201-210 |
| Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth JA; Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to methylmercury.; Neurotoxicology; 1989 Jan; 10(1); 41-52 |
| Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth JA; Cell specific enzyme markers as indicators of neurotoxicity: effects of acuteexposure to methylmercury.; Neurotoxicology; 1989; 10(1); 41-52 |
| Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA; Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes.; Fundam Appl Toxicol; 1988 Oct; 11(3); 519-527 |
| Kostyniak PJ, Brenner JS, Maccubbin AE, Nakeeb S, Kasliwal R, Kung HF; The toxicity and mutagenicity of S-3-iodo-N-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-6-methoxybenzamide (IBZM), a new CNS D-2 dopamine receptor imaging agent.; Drug Chem Toxicol; 1988 Jan; 11(4); 433-442 |
| Peters AS, Schimpfhauser FT, Cheng J, Daly SL, Kostyniak PJ; Effect of a course in cancer prevention on students' attitudes and clinical behavior.; J Med Educ; 1987 Jul; 62(7); 592-600 |
| Kung MP, Kostyniak P, Olson J, Malone M, Roth JA; Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes.; J Appl Toxicol; 1987 Apr; 7(2); 119-121 |
| Mulder KM, Kostyniak PJ; Effect of L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid on urinary excretion of methylmercury in the mouse.; J Pharmacol Exp Ther; 1985 Jul; 234(1); 156-160 |
| Mulder KM, Kostyniak PJ; Involvement of glutathione in the enhanced renal excretion of methyl mercury in CFW Swiss mice.; Toxicol Appl Pharmacol; 1985 May; 78(3); 451-457 |
| Mulder KM, Kostyniak PJ; Stabilization of glutathione in urine and plasma: relevance to urinary metal excretion studies.; J Anal Toxicol; 1985 Jan; 9(1); 31-35 |
| Kostyniak PJ; Mercury in dental amalgams: is there a risk of "mercury poisoning"?; Bull Eighth Dist Dent Soc; 1984 Sep; 18(3); 16-17 |
| Kostyniak PJ; Mercury in dental amalgams: is there a risk of 'mercury poisoning'?; Bull Eighth Dist Dent Soc; 1984 Sep; 18(3); 16-17 |
| Soiefer AI, Kostyniak PJ; Purification of a fluoroacetate-specific defluorinase from mouse liver cytosol.; J Biol Chem; 1984 Sep; 259(17); 10787-10792 |
| Kostyniak PJ, Soiefer AI; A methylmercury toxicity model to test for possible adverse effects resulting from chelating agent therapy.; J Appl Toxicol; 1984 Aug; 4(4); 206-210 |
| Kostyniak PJ, Soiefer AI; The role of fluoroacetate-specific dehalogenase and glutathione transferase in the metabolism of fluoroacetamide and 2,4-dinitrofluorobenzene.; Toxicol Lett; 1984 Aug; 22(2); 217-222 |
| Kostyniak PJ; Preliminary toxicity studies on bis-[beta-(N,N-dimorpholino) ethyl] selenide (MOSE). A new radioimaging agent.; Drug Chem Toxicol; 1984 Jan; 7(1); 41-55 |
| Kostyniak PJ; Preliminary toxicity studies on N,N,N'-trimetyl-N' (2-hydroxyl-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM), a new brain perfusion imaging agent.; Drug Chem Toxicol; 1984 Jan; 7(5); 451-462 |
| Soiefer AI, Kostyniak PJ; The enzymatic defluorination of fluoroacetate in mouse liver cytosol: the separation of defluorination activity from several glutathione S-transferases of mouse liver.; Arch Biochem Biophys; 1983 Sep; 225(2); 928-935 |
| Kostyniak PJ; Methylmercury removal in the dog during infusion of 2,3-dimercaptosuccinic acid (DMSA).; J Toxicol Environ Health; 1983 Apr; 11(4-6); 947-957 |
| Kostyniak PJ; Pharmacokinetics of methylmercury in sheep.; J Appl Toxicol; 1983 Feb; 3(1); 35-38 |
| Kostyniak PJ; An electrothermal atomic absorption method for aluminum analysis in plasma: identification of sources of contamination in blood sampling procedures.; J Anal Toxicol; 1983 Jan; 7(1); 20-23 |
| Kostyniak PJ; Mobilization and removal of methylmercury in the dog during extracorporeal complexing hemodialysis with 2,3-dimercaptosuccinic acid (DMSA).; J Pharmacol Exp Ther; 1982 Apr; 221(1); 63-68 |
| Kostyniak PJ, Clarkson TW; Role of chelating agents in metal toxicity.; Fundam Appl Toxicol; 1981 Sep; 1(5); 376-380 |
| Kostyniak PJ; Differences in elimination rates of methylmercury between two genetic variant strains of mice.; Toxicol Lett; 1980 Oct; 6(6); 405-410 |
| Al-Abbasi AH, Kostyniak PJ, Clarkson TW; An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. III. Clinical applications.; J Pharmacol Exp Ther; 1978 Oct; 207(1); 249-254 |
| Kostyniak PJ, Bosmann HB, Smith FA; Defluorination of fluoroacetate in vitro by rat liver subcellular fractions.; Toxicol Appl Pharmacol; 1978 Apr; 44(1); 89-97 |
| Kostyniak PJ, Clarkson TW, Abbasi AH; An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. II. In vivo applications in the dog.; J Pharmacol Exp Ther; 1977 Nov; 203(2); 253-263 |
| Kostyniak PJ, Clarkson TW, Cestero RV, Freeman RB, Abbasi AH; An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning. I. In vitro studies of the effects of four complexing agents on the distribution and dialyzability of methylmercury in human blood.; J Pharmacol Exp Ther; 1975 Feb; 192(2); 260-269 |
| Kostyniak PJ; An electrothermal atomic absorption method for aluminum analysis in plasma: identification of sources of contamination in blood sampling procedures.; J Anal Toxicol; 7(1); 20-23 |
| Kung MP, Nickerson P, Sansone FM, Olson J, Kostyniak P, Adolf M, Roth J; Effect of chronic exposure to hexachlorophene on rat brain cell specific marker enzymes.; |
| Kung MP, Nickerson P, Sansone FM, Olson J, Kostyniak P, Adolf M, Lein PJ, Roth J; Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes.; |
| Kostyniak PJ; Methylmercury removal in the dog during infusion of 2,3-dimercaptosuccinic acid (DMSA).; J Toxicol Environ Health; 11(4-6); 947-957 |
| Kostyniak PJ; Preliminary toxicity studies on bis-[beta-(N,N-dimorpholino) ethyl] selenide (MOSE). A new radioimaging agent.; Drug Chem Toxicol; 7(1); 41-55 |
| Kostyniak PJ; Preliminary toxicity studies on N,N,N'-trimetyl-N' (2-hydroxyl-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM), a new brain perfusion imaging agent.; Drug Chem Toxicol; 7(5); 451-462 |
| Kostyniak PJ, Clarkson TW; Role of chelating agents in metal toxicity.; Fundam Appl Toxicol; 1(5); 376-380 |
| Mulder KM, Kostyniak PJ; Stabilization of glutathione in urine and plasma: relevance to urinary metal excretion studies.; J Anal Toxicol; 9(1); 31-35 |
| Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ; The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote.; J Biochem Mol Toxicol; 12(1); 41-52 |
| Kostyniak PJ, Brenner JS, Maccubbin AE, Nakeeb S, Kasliwal R, Kung HF; The toxicity and mutagenicity of S-3-iodo-N-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-6-methoxybenzamide (IBZM), a new CNS D-2 dopamine receptor imaging agent.; Drug Chem Toxicol; 11(4); 433-442 |
GRANTS
Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans.
Paul Kostyniak
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FRIENDS Children’s Environmental Health Center
Paul Kostyniak
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Superfund Health & Safety Training Cooperative Agreement
Paul Kostyniak
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