Dr. Te-Chung Lee
Biochemistry
Associate Professor
140 Farber Hall
Buffalo NY, 14214
Phone: (716) 829-3106
Email: chunglee@buffalo.edu
URL: www.acsu.buffalo.edu/~chunglee

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OFFICE LOCATIONS

Office
BRB351
Buffalo NY, 14214

Phone: 829-3106
Fax: 829-3106
Contact: Te-Chung Lee
Email: chunglee@buffalo.edu
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SPECIALTIES

Cardiology


EDUCATION

1989 Doctor of Philosophy, Microbiology and Immunology
Virginia Commonwealth University
1983 Master of Science, M.S. in Biochemistry
National Taiwan University
1981 Bachelor of Science, Botany
National Taiwan University


EXPERTISE

Cell and Molecular Biology


PUBLICATIONS

Suzuki, G. Lee, T.C. Fallavollita, J.A. Canty, J.M., Jr.; Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle.; Circulation Research; 2005; 96; 767-775
Canty JM, Lee TC; Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don>t.; J Mol Cell Cardiol; 2002 Apr; 34(4); 375-377
Canty JM Jr & Lee TC; Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don‘t; J. Mol. Cell. Cardiol.; 2002 Jan; 34; 375-377
Feng J, Schaus BJ, Fallavollita JA, Lee TC, Canty JM; Preload induces troponin I degradation independently of myocardial ischemia.; Circulation; 2001 Apr; 103(16); 2035-2037
Feng J, Schaus BJ, Fallavollita JA, Lee TC & Canty JM Jr; Preload induces troponin degradation independently of myocardial ischemia; Circ. Res.; 2001 Jan; 103; 2035-2037
Kositprapa C, Zhang B, Berger S, Canty JM, Lee TC; Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes.; Mol Cell Biochem; 2000 Nov; 214(1-2); 47-55
Kositprapa C, Zhang B, Berger S, Canty JM Jr. & Lee TC; Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes; Mol. Cell. Biochem.; 2000 Jan; 214; 47-55
Thomas SA, Fallavollita JA, Lee TC, Feng J, Canty JM; Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine.; Circ Res; 1999 Sep; 85(5); 446-456
Hiltke TR, Lee TC, Bobek LA; Structure/function analysis of human cystatin SN and comparison of the cysteine proteinase inhibitory profiles of human cystatins C and SN.; J Dent Res; 1999 Aug; 78(8); 1401-1409
Thomas SA, Fallavollita JA, Lee TC, Feng J & Canty JM Jr; Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression following reversible ischemia in swine; Circ. Res.; 1999 Jan; 85; 446-456
Lee TC, Chow KL, Fang P & Schwartz RJ.; Activation of skeletal a-actin gene transcription: The cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts; Mol. Cell. Biol.; 11; 5090-5100
Mampuru LJ, Chen SJ, Kalenik JL, Bradley ME & Lee TC; Analysis of events associated with serum deprivation-induced apoptosis in C3H/Sol8 muscle satellite cells; Exp. Cell Res.; 226; 372-380
Lee, TC, Zhang, Y & Schwartz, RJ; Bifunctional transcriptional properties of YY1 in regulating oncogene and muscle actin gene transcription; Oncogenes; 9; 1047-1052
Chen SJ, Bradley ME & Lee TC; Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: Modulation by calcium-regulated proteases and protein kinases; Mol. Cell. Biochem.; 178; 141-149
Woover SK, Barrett SK, Lee TC & Bear HD; Cyclophosphamide and abrogation of tumor-induced suppressor-T cells activity; Cancer Immunology and Immunotherapy; 31; 121-127
Lee, TC & Schwartz, RJ; Differential detection of multiple DNA-binding complexes using dissimilar polyanion competitors; Nucl. Acids Res.; 20; 140-140
Lee TC, Shi Y & Schwartz RJ.; Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal a-actin transcription in embryonic myoblasts; Proc. Natl. Acad. Sci. USA; 89; 9814-9818
Te-Chung Lee; Immunosuppression of Concanavalin A and interferon; Bull. Chinese Oncology Soc.; 4; 28-31
Lee TC, Bradley ME & Walowitz JL; Influence of promoter potency on the transcriptional effects of YY1, SRF, and Msx-1 in transient transfection analysis; Nucl. Acid Res.; 26; 3215-3220
Hiltke TR, Lee TC & Bobek LA; Inhibitory profiles of human recombinant cystatins C and SN on several known cysteine proteinases; J. Dental Res.; 78; 1401-1409
Chen, S. -J., Lee, T. -C. & Tung, T. -C.; Interferon induction in inbred Balb/c mice by Abrus Agglutinin; Bull. Chinese Oncology Soc.; 5; 33-38
Lee, TC & Schwartz, RJ; Novel use of a polymeric dye in detecting protein-DNA complexes in gel shift assays; BioTechniques; 15; 390-391
Walowitz JL, Bradley ME, Chen SJ & Lee TC; Proteolytic regulation of the zinc finger transcription factor YY1, a repressor of muscle-restricted gene expression; J. Biol. Chem.; 273; 6656-6661
Lee, TC & Christie, GE; Purification and properties of the bacteriophage P2 ogr gene product: A prokaryotic zinc-binding transcriptional activator; J. Biol. Chem.; 265; 7472-7477
Lee TC, French B, Moss J, Sands A & Schwartz RJ.; Regulation of avian sarcomeric a-actin genes by myogenic helix-loop-helix regulatory factors, serum response factors and F-ACT1; Keystone Symposia on Molecular and Cellular Biology;
Lee, T. -C. and Tung, T. -C; Studies on the toxicity of Abrin to S-180 Sarcoma cells; Bull. Chinese Oncology Soc.; 4; 14-22
MacLellan WR, Lee TC, Schwartz RJ & Schneider MD; TGFb response elements of the skeletal a-actin gene: Cooperative action of serum response factor and the SV-40 enhancer-binding protein, TEF-1; J. Biol. Chem.; 269; 16754-16760
Lee, TC & Schwartz, RJ; Using protease to avoid false identification of protein-DNA complexes in gel shift assays; BioTechniques; 12; 486-490
Kalenik JL, Chen D, Bradley ME, Chen SJ & Lee TC; Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1; Nucl. Acid Res.; 25; 843-849


GRANTS

January 2001 to March 2002
Calpain Regulation in Muscle Cells
MDA
Te-Chung Lee
December 1999 to November 2004
Apoptosis and contractility in ischemic cardiomyopathy
NIH
Te-Chung Lee, John Canty
January 1998 to December 2001
Calcium-regulated proteolysis in cardiomyocyte apoptosis
AHA
Te-Chung Lee
July 1996 to June 2001
Chronic adaptations to myocardial ischemia
NIH
Te-Chung Lee, John Canty
January 1995 to December 1997
Molecular mechanisms of muscle cell growth and differentiation
MDA
Te-Chung Lee
July 1994 to June 1996
Transcriptional mechanisms governing protooncogene expression in cultured cardiac myocytes
AHA
Te-Chung Lee



 
Dr. Te-Chung Lee
Dr. Te-Chung Lee