Dr. Timothy Murphy
Medicine
Senior Associate Dean for Clinical and Translational Research
Center of Excellence for Bioinformatics and Life Sciences
701 Ellicott St.
B3-318
Buffalo NY, 14203
Phone: (716) 881-8010
Fax: (716) 849-6655
Email: murphyt@buffalo.edu
URL: http://www.smbs.buffalo.edu/med/ID/images/facultypic/murphy.jpg

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OFFICE LOCATIONS

Center of Excellence in Bioinformatics and Life Sciences
701 Ellicott St.
Buffalo NY, 14203

Phone: 881-8911
Fax: 849-6655
Contact: Cookie Thurston
Email: murphyt@acsu.buffalo.edu
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Insurance Accepted
Veterans Administration


DESCRIPTION OF INTERESTS

Respiratory tract bacterial pathogens
Vaccine development
Bacterial infection in chronic obstructive pulmonary disease
Haemophilus influenzae
Moraxella catarrhalis

Research in my laboratory focuses on nontypeable Haemophilus influenzae and Moraxella catarrhalis, important pathogens in otitis media and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). A goal of work is to develop vaccine to prevent these infections. To that end, outer membrane proteins have been identified and are being evaluated as potential vaccine antigens.

A COPD Study Clinic supported by a grant from the Department of Veteran Affairs has been running continuously since 1994. This prospective study follows adults with COPD during monthly clinic visits during which sputum and serum samples are collected. Bacterial isolates are recovered from sputum and are subjected to molecular typing. These studies are elucidating the dynamics of respiratory tract bacterial colonization. In addition, serum and sputum samples are being studied to learn about systemic and mucosal immune responses to bacterial pathogens.


SPECIALTIES

Infectious Disease


EDUCATION

1981 Fellowship, Infectious Diseases
Tufts University
1979 Residency, Medicine
New York Hospital Cornell Medical Center
1976 MD, Tufts University


PUBLICATIONS

Sabirov A, Casey JR, Murphy TF, Pichichero ME; Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6.; Pediatr Res; 2009 Nov; 66(5); 565-570
Ruckdeschel EA, Brauer AL, Johnson A, Murphy TF; Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis.; Vaccine; 2009 Nov; 27(50); 7065-7072
Schwingel JM, Edwards KJ, Cox AD, Masoud H, Richards JC, St Michael F, Tekwe CD, Sethi S, Murphy TF, Campagnari AA; Use of Moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies.; Infect Immun; 2009 Oct; 77(10); 4548-4558
Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz LO; Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates.; Vaccine; 2009 Aug;
Murphy TF, Parameswaran GI; Moraxella catarrhalis, a human respiratory tract pathogen.; Clin Infect Dis; 2009 Jul; 49(1); 124-131
Murphy TF; Vaccine development for Moraxella catarrhalis: rationale, approaches and challenges.; Expert Rev Vaccines; 2009 Jun; 8(6); 655-658
Murphy TF; Current and Future Prospects for a Vaccine for Nontypeable Haemophilus influenzae.; Curr Infect Dis Rep; 2009 May; 11(3); 177-182
LaFontaine ER, Snipes LE, Bullard B, Brauer AL, Sethi S, Murphy TF; Identification of domains of the Hag/MID surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of Moraxella catarrhalis.; Clin Vaccine Immunol; 2009 May; 16(5); 653-659
Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, Stämpfli MR; Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile.; Am J Respir Crit Care Med; 2009 Apr; 179(8); 666-675
Murphy TF; Pseudomonas aeruginosa in adults with chronic obstructive pulmonary disease.; Curr Opin Pulm Med; 2009 Mar; 15(2); 138-142
Ostberg KL, Russell MW, Murphy TF; Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae; Mucosal Immunol; 2009; 2; 63-73
Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, Virji M, Pelton SI; Nontypeable Haemophilus influenzae as a pathogen in children.; Pediatr Infect Dis J; 2009 Jan; 28(1); 43-48
Murphy TF; Placebo-controlled trials of treatments for community-acquired pneumonia: review of the literature and discussion of feasibility and potential value.; Clin Infect Dis; 2008 Dec; 47 Su; 145-149
Murphy TF; The many faces of Pseudomonas aeruginosa in chronic obstructive pulmonary disease.; Clin Infect Dis; 2008 Dec; 47(12); 1534-1536
Sethi S, Murphy TF; Infection in the pathogenesis and course of chronic obstructive pulmonary disease.; N Engl J Med; 2008 Nov; 359(22); 2355-2365
Cholon DM, Cutter D, Richardson SK, Sethi S, Murphy TF, Look DC, St Geme JW; Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins.; Infect Immun; 2008 Aug;
Ruckdeschel EA, Kirkham C, Lesse AJ, Hu Z, Murphy TF; Mining the Moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection.; Infect Immun; 2008 Apr; 76(4); 1599-1607
Sethi S, Wrona C, Eschberger K, Lobbins P, Cai X, Murphy TF; Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2008 Mar; 177(5); 491-497
McCrea KW, Xie J, LaCross N, Patel M, Mukundan D, Murphy TF, Marrs CF, Gilsdorf JR; Relationships of nontypeable Haemophilus influenzae strains to hemolytic and nonhemolytic Haemophilus haemolyticus strains.; J Clin Microbiol; 2008 Feb; 46(2); 406-416
Murphy TF, Brauer AL, Eschberger K, Lobbins P, Grove L, Cai X, Sethi S; Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease.; Am J Respir Crit Care Med; 2008 Jan;
Sethi S, Wrona C, Eschberger K, Lobbins P, Cai X, Murphy TF; Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease.; Am J Respir Crit Care Med; 2007 Dec;
Parameswaran GI, Murphy TF; Infections in chronic lung diseases.; Infect Dis Clin North Am; 2007 Sep; 21(3); 673-695
Malley R, Lipsitch M, Bogaert D, Thompson CM, Hermans P, Watkins AC, Sethi S, Murphy TF; Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease.; J Infect Dis; 2007 Sep; 196(6); 928-935
Sethi S, Sethi R, Eschberger K, Lobbins P, Cai X, Grant BJ, Murphy TF; Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2007 Aug; 176(4); 356-361
Murphy TF, Brauer AL, Sethi S, Kilian M, Cai X, Lesse AJ; Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae.; J Infect Dis; 2007 Jan; 195(1); 81-89
Fung WW, O'Dwyer CA, Sinha S, Brauer AL, Murphy TF, Kroll JS, Langford PR; Presence of copper- and zinc-containing superoxide dismutase in commensal Haemophilus haemolyticus isolates can be used as a marker to discriminate them from nontypeable H. influenzae isolates.; J Clin Microbiol; 2006 Nov; 44(11); 4222-4226
Fernaays MM, Lesse AJ, Cai X, Murphy TF; Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae.; Infect Immun; 2006 Oct; 74(10); 5860-5870
Murphy TF, Kirkham C, Lesse AJ; Construction of a mutant and characterization of the role of the vaccine antigen P6 in outer membrane integrity of nontypeable Haemophilus influenzae.; Infect Immun; 2006 Sep; 74(9); 5169-5176
Kurita S, Koyama J, Onizuka S, Motomura K, Watanabe H, Watanabe K, Senba M, Apicella MA, Murphy TF, Yoneyama H, Matsushima K, Nagatake T, Oishi K; Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein.; Vaccine; 2006 Jul; 24(31-32); 5896-5903
Fernaays MM, Lesse AJ, Sethi S, Cai X, Murphy TF; Differential genome contents of nontypeable Haemophilus influenzae strains from adults with chronic obstructive pulmonary disease.; Infect Immun; 2006 Jun; 74(6); 3366-3374
Murphy TF; The role of bacteria in airway inflammation in exacerbations of chronic obstructive pulmonary disease.; Curr Opin Infect Dis; 2006 Jun; 19(3); 225-230
Murphy TF; Otitis media, bacterial colonization, and the smoking parent.; Clin Infect Dis; 2006 Apr; 42(7); 904-906
Neary JM, Murphy TF; Antibodies directed at a conserved motif in loop 6 of outer membrane protein P2 of nontypeable Haemophilus influenzae recognize multiple strains in immunoassays.; FEMS Immunol Med Microbiol; 2006 Mar; 46(2); 251-261
Murphy TF, Brauer A., Sethi S, Kilian M., Cai X., Lesse A; Haemophilus hemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae.; Journal of Infectious Disease; 2006 Jan; 195(1); 81-89
Adlowitz D., Kirkham, C., Sethi S, Murphy TF; Human Serum and Mucosal Antibody Responses to Outer Membrane Protein G1b of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease.; FEMS Immunology; 2006; 46(1); 139-146
Look D.C., Chin C.L., Manzel L.J., Lehman E.E., Humlicek A.L., Shi L., Starner T.D., Denning G.M., Murphy TF, Sethi S; Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation.; Proceedings of the American Thoracic Society; 2006; 3(6); 482-483
Murphy TF; Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis: progress and challenges.; Expert Rev Vaccines; 2005 Dec; 4(6); 843-853
Wu T, Chen J, Murphy TF, Green BA, Gu XX; Investigation of non-typeable Haemophilus influenzae outer membrane protein P6 as a new carrier for lipooligosaccharide conjugate vaccines.; Vaccine; 2005 Oct; 23(44); 5177-5185
Chin CL, Manzel LJ, Lehman EE, Humlicek AL, Shi L, Starner TD, Denning GM, Murphy TF, Sethi S, Look DC; Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers.; Am J Respir Crit Care Med; 2005 Jul; 172(1); 85-91
Murphy TF, Brauer AL, Grant BJ, Sethi S; Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response.; Am J Respir Crit Care Med; 2005 Jul; 172(2); 195-199
Murphy TF, Brauer A., Grant BJ, Sethi S; Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease, dynamics of carriage and immune responses; American Journal of Respiratory and Critical Care Medicine; 2005 Jul; 172(2); 195-199
McMahon M, Murphy TF, Kyd J, Thanavala Y; Role of an immunodominant T cell epitope of the P6 protein of nontypeable Haemophilus influenzae in murine protective immunity.; Vaccine; 2005 May; 23(27); 3590-3596
Murphy TF, Kirkham C, Sethi S, Lesse AJ; Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection.; FEMS Immunol Med Microbiol; 2005 Apr; 44(1); 81-89
Sethi S, Murphy TF; RSV infection--not for kids only.; N Engl J Med; 2005 Apr; 352(17); 1810-1812
Murphy TF, Bakaletz LO, Kyd JM, Watson B, Klein DL; Vaccines for otitis media: proposals for overcoming obstacles to progress.; Vaccine; 2005 Apr; 23(21); 2696-2702
Murphy TF, Brauer, A.L., Adler, B., Sethi S; Antigenic specificity of the mucosal antibody response to Moraxella catarrhalis in chronic obstructive pulmonary disease.; Infection and Immunity; 2005; 73(12); 8161-8166
Chin C.L., Manzel L.J., Lehman E.E., Humlicek, A.L., Shi L., Starner T.D., Denning G.M., Murphy TF, Sethi S, Look D.C.; Haemophilus influenzae from patients with COPD exacerbation induce more inflammation than colonizers.; American Journal of Respiratory and Critical Care Medicine; 2005; 172; 85-91
Adlowitz D., Sethi S, Adler B., Cullen, P., Murphy TF; Human Antibody Response to Outer Membrane Protein G1a, a Lipoprotein of Moraxella catarrhalis.; Infection and Immunity; 2005; 73(10); 6601-6607
Murphy TF, Brauer A.L., Aebi C., Sethi S; Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease.; Infection and Immunity; 2005; 73(6); 3471-3478
Berenson CS, Murphy TF, Wrona, C.T., Sethi S; Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage cytokines; Infection and Immunity; 2005; 73(5); 2728-2735
Barenkamp SJ, Kurono Y, Ogra PL, Leiberman A, Bakaletz LO, Murphy TF, Chonmaitree T, Patel JA, Heikkinen T, Sih TM, Hurst DS, St Geme JW, Kawauchi H, Stenfors LE; Recent advances in otitis media. 5. Microbiology and immunology.; Ann Otol Rhinol Laryngol Suppl; 2005 Jan; 194; 60-85
Giebink GS, Kurono Y, Bakaletz LO, Kyd JM, Barenkamp SJ, Murphy TF, Green B, Ogra PL, Gu XX, Patel JA, Heikkinen T, Pelton SI, Hotomi M, Karma P; Recent advances in otitis media. 6. Vaccine.; Ann Otol Rhinol Laryngol Suppl; 2005 Jan; 194; 86-103
Sethi S, Murphy TF; RSV infection: not for kids only; New England Journal of Medicine; 2005; 352(17); 1810-1812
Sethi S, Murphy TF; Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy.; Infect Dis Clin North Am; 2004 Dec; 18(4); 861-882
Chen R, Lim JH, Jono H, Gu XX, Kim YS, Basbaum CB, Murphy TF, Li JD; Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways.; Biochem Biophys Res Commun; 2004 Nov; 324(3); 1087-1094
Murphy TF, Brauer AL, Schiffmacher AT, Sethi S; Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2004 Aug; 170(3); 266-272
Adlowitz DG, Hiltke T, Lesse AJ, Murphy TF; Identification and characterization of outer membrane proteins G1a and G1b of Moraxella catarrhalis.; Vaccine; 2004 Jun; 22(20); 2533-2540
Sethi S, Wrona C, Grant BJ, Murphy TF; Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2004 Feb; 169(4); 448-453
Bandi V, Jakubowycz M, Kinyon C, Mason EO, Atmar RL, Greenberg SB, Murphy TF; Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzae.; FEMS Immunol Med Microbiol; 2003 Jun; 37(1); 69-75
Murphy TF; Respiratory infections caused by non-typeable Haemophilus influenzae.; Curr Opin Infect Dis; 2003 Apr; 16(2); 129-134
Murphy TF; Immunity to nontypeable Haemophilus influenzae: elucidating protective responses.; Am J Respir Crit Care Med; 2003 Feb; 167(4); 486-487
MURPHY TF; Exacerbations of COPD associated with respiratory viruses and nontypeable Haemophilus influenzae.; FEMS Immunology and Medical Microbiology; 2003; 37; 69-75
MURPHY TF; Horizontal transfer of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in a patient with chronic obstructive pulmonary disease.; Journal of Infectious Diseases; 2003 Jan; 188; 114-117
MURPHY TF; Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease.; Infection and Immunity; 2003; 71; 1288-1294
MURPHY TF; Immunity to Nontypeable Haemophilus influenzae. Elucidating protective responses.; American Journal fo Respiratory and Critical Care Medicine; 2003; 167; 486-487
Murphy TF, Kirkham C; Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili.; BMC Microbiol; 2002 Apr; 2; 7-7
Abe Y, Murphy TF, Sethi S, Faden HS, Dmochowski J, Harabuchi Y, Thanavala YM; Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2002 Apr; 165(7); 967-971
Bakaletz LO, Barenkamp SJ, Eskola J, Green B, Gu XX, Harada T, Heikkinen T, Karma P, Klein JO, Kurono Y, Mogi G, Murphy TF, Ogra PL, Patel JA, Suzuki M, Yamanaka N; Recent advances in otitis media. 7. Vaccine.; Ann Otol Rhinol Laryngol Suppl; 2002 Mar; 188; 82-94
Hiltke TJ, Sethi S, Murphy TF; Sequence stability of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in the human respiratory tract.; J Infect Dis; 2002 Mar; 185(5); 627-631
Bakri F, Brauer AL, Sethi S, Murphy TF; Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease.; J Infect Dis; 2002 Mar; 185(5); 632-640
Murphy TF, Sethi S; Chronic obstructive pulmonary disease: Role of bacteria and guide to antibacterial selection in the older patient; Drugs and Aging; 2002; 19; 761-775
Murphy TF, Sethi S, Hill SL, Stockley RA; Inflammatory markers in bacterial exacerbations of COPD.; Am J Respir Crit Care Med; 2002 Jan; 165(1); 132-132
Sethi S, Evans N, Grant BJ, Murphy TF; New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.; New England Journal of Medicine; 2002; 347(7); 465-471
Bernstein JM, Dryja D, Murphy TF; Molecular typing of paired bacterial isolates from the adenoid and lateral wall of the nose in children undergoing adenoidectomy: implications in acute rhinosinusitis.; Otolaryngol Head Neck Surg; 2001 Dec; 125(6); 593-597
Bandi V, Apicella MA, Mason E, Murphy TF, Siddiqi A, Atmar RL, Greenberg SB; Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis.; Am J Respir Crit Care Med; 2001 Dec; 164(11); 2114-2119
Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, Murphy TF, Lim DJ, Li JD; Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells.; Proc Natl Acad Sci U S A; 2001 Jul; 98(15); 8774-8779
Murphy TF, Brauer AL, Yuskiw N, McNamara ER, Kirkham C; Conservation of outer membrane protein E among strains of Moraxella catarrhalis.; Infect Immun; 2001 Jun; 69(6); 3576-3580
Sethi S, Murphy TF; Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review.; Clin Microbiol Rev; 2001 Apr; 14(2); 336-363
Neary JM, Yi K, Karalus RJ, Murphy TF; Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains.; Infect Immun; 2001 Feb; 69(2); 773-778
Sethi S, Muscarella K, Evans N, Klingman KL, Grant BJ, Murphy TF; Airway inflammation and etiology of acute exacerbations of chronic bronchitis.; Chest; 2000 Dec; 118(6); 1557-1565
Sethi S, Murphy TF; Chronic obstructive pulmonary disease.; N Engl J Med; 2000 Dec; 343(26); 1969-1970
Murphy TF, Brauer AL, Yuskiw N, Hiltke TJ; Antigenic structure of outer membrane protein E of Moraxella catarrhalis and construction and characterization of mutants.; Infect Immun; 2000 Nov; 68(11); 6250-6256
Barton BE, Murphy TF; Constitutive expression of IL-6-LIKE cytokines in normal bone marrow: implications for pathophysiology of myeloma.; Cytokine; 2000 Oct; 12(10); 1537-1545
Murphy TF, Sethi S, Niederman MS; The role of bacteria in exacerbations of COPD. A constructive view.; Chest; 2000 Jul; 118(1); 204-209
Murphy TF; Bacterial otitis media: pathogenetic considerations.; Pediatr Infect Dis J; 2000 May; 19(5 Sup); 9-15
Samukawa T, Yamanaka N, Hollingshead S, Murphy TF, Faden H; Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media.; J Infect Dis; 2000 May; 181(5); 1842-1845
Murphy TF; Haemophilus influenzae in chronic bronchitis.; Semin Respir Infect; 2000 Mar; 15(1); 41-51
Sethi S., Muscarella, K.A., Evans, N., Klingman, K.L., & Murphy, T.F.; Acute bacterial exacerbations of COPD are associated with greater airway inflammation than non-bacterial exacerbations; Chest; 2000 Jan; 118; 1557-1565
Karalus RJ, Murphy TF; Purification and characterization of outer membrane protein P6, a vaccine antigen of non-typeable Haemophilus influenzae.; FEMS Immunol Med Microbiol; 1999 Nov; 26(2); 159-166
Kyd J, John A, Cripps A, Murphy TF; Investigation of mucosal immunisation in pulmonary clearance of Moraxella (Branhamella) catarrhalis.; Vaccine; 1999 Oct; 18(5-6); 398-406
Murphy TF, Kirkham C, DeNardin E, Sethi S; Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis.; Infect Immun; 1999 Sep; 67(9); 4578-4585
Badr WH, Loghmanee D, Karalus RJ, Murphy TF, Thanavala Y; Immunization of mice with P6 of nontypeable Haemophilus influenzae: kinetics of the antibody response and IgG subclasses.; Vaccine; 1999 Aug; 18(1-2); 29-37
Murphy TF, Sethi S, Klingman KL, Brueggemann AB, Doern GV; Simultaneous respiratory tract colonization by multiple strains of nontypeable haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy.; J Infect Dis; 1999 Aug; 180(2); 404-409
Murphy TF, Kyd JM, John A, Kirkham C, Cripps AW; Enhancement of pulmonary clearance of Moraxella (Branhamella) catarrhalis following immunization with outer membrane protein CD in a mouse model.; J Infect Dis; 1998 Dec; 178(6); 1667-1675
Harabuchi Y, Murakata H, Goh M, Kodama H, Kataura A, Faden H, Murphy TF; Serum antibodies specific to CD outer membrane protein of Moraxella catarrhalis, P6 outer membrane protein of non-typeable Haemophilus influenzae and capsular polysaccharides of Streptococcus pneumoniae in children with otitis media with effusion.; Acta Otolaryngol; 1998 Nov; 118(6); 826-832
Qiu J, Hendrixson DR, Baker EN, Murphy TF, St Geme JW, Plaut AG; Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae.; Proc Natl Acad Sci U S A; 1998 Oct; 95(21); 12641-12646
Murphy TF; Lung infections. 2. Branhamella catarrhalis: epidemiological and clinical aspects of a human respiratory tract pathogen.; Thorax; 1998 Feb; 53(2); 124-128
Kyd JM, Cripps AW, Murphy TF; Outer-membrane antigen expression by Moraxella (Branhamella) catarrhalis influences pulmonary clearance.; J Med Microbiol; 1998 Feb; 47(2); 159-168
Murphy TF, Yi K; Mechanisms of recurrent otitis media: importance of the immune response to bacterial surface antigens.; Ann N Y Acad Sci; 1997 Dec; 830; 353-360
Yi K, Sethi S, Murphy TF; Human immune response to nontypeable Haemophilus influenzae in chronic bronchitis.; J Infect Dis; 1997 Nov; 176(5); 1247-1252
Bernstein JM, Dryja D, Yuskiw N, Murphy TF; Analysis of isolates recovered from multiple sites of the nasopharynx of children colonized by nontypeable Haemophilus influenzae.; Eur J Clin Microbiol Infect Dis; 1997 Oct; 16(10); 750-753
Sethi S, Surface JM, Murphy TF; Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella) catarrhalis.; Infect Immun; 1997 Sep; 65(9); 3666-3671
Bhushan R, Kirkham C, Sethi S, Murphy TF; Antigenic characterization and analysis of the human immune response to outer membrane protein E of Branhamella catarrhalis.; Infect Immun; 1997 Jul; 65(7); 2668-2675
Murphy TF, Sethi S; A national strategy for research in chronic obstructive pulmonary disease.; JAMA; 1997 May; 277(20); 1596-1596
Fakih MG, Murphy TF, Pattoli MA, Berenson CS; Specific binding of Haemophilus influenzae to minor gangliosides of human respiratory epithelial cells.; Infect Immun; 1997 May; 65(5); 1695-1700
Reddy MS, Murphy TF, Faden HS, Bernstein JM; Middle ear mucin glycoprotein: purification and interaction with nontypable Haemophilus influenzae and Moraxella catarrhalis.; Otolaryngol Head Neck Surg; 1997 Feb; 116(2); 175-180
Yi K, Murphy TF; Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae.; Infect Immun; 1997 Jan; 65(1); 150-155
Sen K, Sikkema DJ, Murphy TF; Isolation and characterization of the Haemophilus influenzae tolQ, tolR, tolA and tolB genes.; Gene; 1996 Oct; 178(1-2); 75-81
Murphy TF; Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune response.; Microbiol Rev; 1996 Jun; 60(2); 267-279
Reddy MS, Bernstein JM, Murphy TF, Faden HS; Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin.; Infect Immun; 1996 Apr; 64(4); 1477-1479
Berenson CS, Patterson MA, Pattoli MA, Murphy TF; A monoclonal antibody to human macrophage gangliosides inhibits macrophage migration.; J Leukoc Biol; 1996 Mar; 59(3); 371-379
Sethi S, Murphy TF, Klingman KL; Diagnosis, epidemiology and pathogenesis of bacterial infections in the molecular era.; Clin Mol Pathol; 1996 Feb; 49(1); 1-7
Sethi S., Murphy, T.F., & Klingman, K.L.; Diagnosis, epidemiology & pathogenesis of bacterial infection in the molecular era; Clinical Pathology:Molecular Pathology; 1996 Jan; 49; M1-M7
Hsiao CB, Sethi S, Murphy TF; Outer membrane protein CD of Branhamella catarrhalis: sequence conservation in strains recovered from the human respiratory tract.; Microb Pathog; 1995 Oct; 19(4); 215-225
Klingman KL, Pye A, Murphy TF, Hill SL; Dynamics of respiratory tract colonization by Branhamella catarrhalis in bronchiectasis.; Am J Respir Crit Care Med; 1995 Sep; 152(3); 1072-1078
Sethi S, Hill SL, Murphy TF; Serum antibodies to outer membrane proteins (OMPs) of Moraxella (Branhamella) catarrhalis in patients with bronchiectasis: identification of OMP B1 as an important antigen.; Infect Immun; 1995 Apr; 63(4); 1516-1520
HSIAO C; Outer membrane protein CD of Branhamella catarrhalis: sequnce conservation in strains recovered from the human respiratory tract.; Microbial Pathogenesis; 1995; 19; 215-225
Murphy TF; Antigenic variation of surface proteins as a survival strategy for bacterial pathogens.; Trends Microbiol; 1994 Nov; 2(11); 427-428
Bhushan R, Craigie R, Murphy TF; Molecular cloning and characterization of outer membrane protein E of Moraxella (Branhamella) catarrhalis.; J Bacteriol; 1994 Nov; 176(21); 6636-6643
Yi K, Murphy TF; Mapping of a strain-specific bactericidal epitope to the surface-exposed loop 5 on the P2 porin protein of non-typeable Haemophilus influenzae.; Microb Pathog; 1994 Oct; 17(4); 277-282
Haase EM, Yi K, Morse GD, Murphy TF; Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae.; Infect Immun; 1994 Sep; 62(9); 3712-3722
Haase EM, Yi K, Morse GD, Murphy TF, Morse ED; Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae.; Infect Immun; 1994 Sep; 62(9); 3712-3722
Klingman KL, Murphy TF; Purification and characterization of a high-molecular-weight outer membrane protein of Moraxella (Branhamella) catarrhalis.; Infect Immun; 1994 Apr; 62(4); 1150-1155
Murphy TF, Kirkham C, Lesse AJ; The major heat-modifiable outer membrane protein CD is highly conserved among strains of Branhamella catarrhalis.; Mol Microbiol; 1993 Oct; 10(1); 87-97
Burnett D, Chamba A, Stockley RA, Murphy TF, Hill SL; Effects of recombinant GM-CSF and IgA opsonisation on neutrophil phagocytosis of latex beads coated with P6 outer membrane protein from Haemophilus influenzae.; Thorax; 1993 Jun; 48(6); 638-642
Murphy, T.F. & Sethi,S.; Preventing or treating COPD flare-ups; Emergency Medicine; 1993 Jan; 25; 65-68
Sikkema DJ, Murphy TF; Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae.; Infect Immun; 1992 Dec; 60(12); 5204-5211
Murphy TF, Sethi S; Bacterial infection in chronic obstructive pulmonary disease.; Am Rev Respir Dis; 1992 Oct; 146(4); 1067-1083
Murphy TF; Haemophilus influenzae and viruses 100 years later: from influenza to human immunodeficiency virus.; Am J Med; 1992 Jun; 92(6); 583-586
Murphy TF, Nelson MB, Apicella MA; The P6 outer membrane protein of nontypeable Haemophilus influenzae as a vaccine antigen.; J Infect Dis; 1992 Jun; 165 S; 203-205
Murphy TF, Kirkham C, Sikkema DJ; Neonatal, urogenital isolates of biotype 4 nontypeable Haemophilus influenzae express a variant P6 outer membrane protein molecule.; Infect Immun; 1992 May; 60(5); 2016-2022
Sikkema DJ, Nelson MB, Apicella MA, Murphy TF; Outer membrane protein P6 of Haemophilus influenzae binds to its own gene.; Mol Microbiol; 1992 Feb; 6(4); 547-554
Bernstein JM, Faden HS, Loos BG, Murphy TF, Ogra PL; Recurrent otitis media with non-typable Haemophilus influenzae: the role of serum bactericidal antibody.; Int J Pediatr Otorhinolaryngol; 1992 Jan; 23(1); 1-13
Nelson MB, Munson RS, Apicella MA, Sikkema DJ, Molleston JP, Murphy TF; Molecular conservation of the P6 outer membrane protein among strains of Haemophilus influenzae: analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms.; Infect Immun; 1991 Aug; 59(8); 2658-2663
Moeser PJ, Costello PB, Gillikin S, Murphy TF; Haemophilus influenzae polyarthritis in an adult: an analysis of serotype b strains.; Rev Infect Dis; 1991 Jan; 13(1); 61-63
Murphy TF; Molecular biology and respiratory disease. 6. Modern molecular biology and respiratory bacterial infections: a revolution on the horizon.; Thorax; 1990 Jul; 45(7); 552-559
Murphy TF; Studies of the outer membrane proteins of Branhamella catarrhalis.; Am J Med; 1990 May; 88(5A); 41-45
Murphy TF, Bartos LC; Surface-exposed and antigenically conserved determinants of outer membrane proteins of Branhamella catarrhalis.; Infect Immun; 1989 Oct; 57(10); 2938-2941
Loos BG, Bernstein JM, Dryja DM, Murphy TF, Dickinson DP; Determination of the epidemiology and transmission of nontypable Haemophilus influenzae in children with otitis media by comparison of total genomic DNA restriction fingerprints.; Infect Immun; 1989 Sep; 57(9); 2751-2757
Murphy TF, Loeb MR; Isolation of the outer membrane of Branhamella catarrhalis.; Microb Pathog; 1989 Mar; 6(3); 159-174
Murphy TF; The surface of Branhamella catarrhalis: a systematic approach to the surface antigens of an emerging pathogen.; Pediatr Infect Dis J; 1989 Jan; 8(1 Sup); 75-77
Bartos LC, Murphy TF; Comparison of the outer membrane proteins of 50 strains of Branhamella catarrhalis.; J Infect Dis; 1988 Oct; 158(4); 761-765
Murphy TF, Bartos LC; Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae.; Infect Immun; 1988 Oct; 56(10); 2673-2679
Nelson MB, Murphy TF, van Keulen H, Rekosh D, Apicella MA; Studies on P6, an important outer-membrane protein antigen of Haemophilus influenzae.; Rev Infect Dis; 1988 Jul; 10 Su; 331-336
Murphy TF, Bartos LC; Purification and analysis with monoclonal antibodies of P2, the major outer membrane protein of nontypable Haemophilus influenzae.; Infect Immun; 1988 May; 56(5); 1084-1089
Nelson MB, Apicella MA, Murphy TF, Vankeulen H, Spotila LD, Rekosh D; Cloning and sequencing of Haemophilus influenzae outer membrane protein P6.; Infect Immun; 1988 Jan; 56(1); 128-134
Klingman KL, Jansen(Haase) EM, Murphy TF; Nearest Neighbor Analysis of Outer Membrane Proteins of Nontypeable Haemophilus influenzae.; Infect Immun; 1988 Jan; 56; 3058-3063
Campagnari AA, Gupta MR, Dudas KC, Murphy TF, Apicella MA; Antigenic diversity of lipooligosaccharides of nontypable Haemophilus influenzae.; Infect Immun; 1987 Apr; 55(4); 882-887
Murphy TF, Apicella MA; Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection.; Rev Infect Dis; 1987 Jan; 9(1); 1-15
Murphy TF, Bartos LC, Rice PA, Nelson MB, Dudas KC, Apicella MA; Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody.; J Clin Invest; 1986 Oct; 78(4); 1020-1027
Apicella MA, Dudas KC, Anthony Campagnari, Rice P, Joseph Mylotte, Murphy TF; Antigenic heterogeneity of lipid A of Haemophilus influenzae.; Infect Immun; 1985 Oct; 50(1); 9-14
Murphy TF, Apicella MA; Antigenic heterogeneity of outer membrane proteins of nontypable Haemophilus influenzae is a basis for a serotyping system.; Infect Immun; 1985 Oct; 50(1); 15-21


GRANTS

January 2001 to January 2006
Recurrent otitis media and COPD: immunity and vaccines. Program Project(PO1AI46422). Project 2: Defining a protective immune response to Moraxella catarrhalis in humans
NIH
Timothy Murphy
$2,000,000
January 2001 to January 2006
Research in infectious diseases, microbiology and immunology for medical students (T32AI49838)
NIH
Timothy Murphy
$214,000
January 1995 to January 1996
Fogarty Senior International Fellowship
Timothy Murphy
January 1993 to March 2010
Bacterial infection in COPD
Department of Veterans Affairs/Merit Review
Timothy Murphy
$750,000
January 1987 to January 2010
Development of a vaccine for Moraxella catarrhalis (RO1AI28304)
NIH
Timothy Murphy
$1,250,000
January 1983 to December 2012
Development of a vaccine for nontypeable H. influenzae and Pathogenesis of nontypeable Haemophilus influenzae(2RO1AI019641)
NIH
Timothy Murphy
$1,250,000



 
Dr. Timothy Murphy
Dr. Timothy Murphy