Dr. James Olson Pharmacology And Toxicology Professor Office - 13 Cary Hall 102 Farber Hall 3435 Main St Buffalo NY, 14214 Phone: (716) 829-2319 Fax: (716) 829-2801 Email: jolson@buffalo.edu View map

DESCRIPTION OF INTERESTS

Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides • Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of organophosphate pesticides (OPs). • Identify new biomarkers of susceptibility to this class of pesticides by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification. Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs). • Assessing Human Exposures to dioxins, PBDEs, and PCBs • Metabolism and disposition of dioxins, PBDEs, and PCBs • Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs and mechanisms for adverse heath effects. • Identify alterations in global gene expression and specific pathways that may be associated with pathological responses of AhR ligands (dioxins, PCB126) and non- AhR ligands (PCB153). • Characterizing the adverse effects of dioxin on lung development and the role of the AhR pathway in the developing lung.

EDUCATION

1978	Ph.D., Pharmacology-Toxicology Medical College of Wisconsin
1976	Master of Science, Pharmacology Medical College of Wisconsin
1974	Bachelor of Arts, Chemistry Illinois Wesleyan University

PUBLICATIONS

Kransler KM, McGarrigle BP, Russell RJ, Olson JR; Effects of Helicobacter infection on developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats.; Lab Anim (NY); 2008 Apr; 37(4); 171-175

Kransler, K.M., Tonucci, D.A., McGarrigle, B.P., Napoli, J.L. and Olson, J.R.; Gestational Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat.; Toxicology and Applied Pharmacology; 2007 Oct; 224;

Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR; Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.; Drug Metab Dispos; 2007 Feb; 35(2); 189-193

Catania JR, McGarrigle BP, Rittenhouse-Olson K, Olson JR; Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium.; Toxicol In Vitro; 2007 Feb; 21(1); 109-115

McCann, S. E., Wactawski-Wende, J., Olson, J. R., Ovando, B.J., Nowell, S., Davis, W., Carter, L., Muti, P., Shields, P.G. and J. L. Freudenheim.; Changes in 2- and 16a-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype.; Cancer Epidemiology, Biomarkers and Prevention; 2007; 16(2); 256-262

Kransler KM, McGarrigle BP, Olson JR; Comparative developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the hamster, rat and guinea pig.; Toxicology; 2007 Jan; 229(3); 214-225

Kransler KM, Tonucci DA, McGarrigle BP, Napoli JL and Olson JR ; Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters Retinoid Homeostasis in Maternal and Perinatal Tissues of the Holtzman Rat; Toxicology and Applied Pharmacology; 2007;

Ovando BJ, Vezina CM, McGarrigle BP, Olson JR; Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.; Toxicol Sci; 2006 Dec; 94(2); 428-438

Harrigan JA, McGarrigle BP, Sutter TR, Olson JR; Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liverand lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene.; Toxicol In Vitro; 2006 Jun; 20(4); 426-438

Bloom M, Vena J, Olson J, Moysich K; Chronic exposure to dioxin-like compounds and thyroid function among New York anglers.; Environmental Toxicology and Pharmacology; 2006; 21(3); 260-267

Schecter A, Päpke O, Harris TR, Tung KC, Musumba A, Olson J, and Birnbaum L; Polybrominated Diphenyl Ether (PBDE) Levels in an Expanded Market Basket Survey of United States (U.S) Food and Estimated PBDE Dietary Intake by Age and Gender.; Environmental Health Perspectives; 2006; 114; 1515-1520

Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL; Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish.; Toxicol Sci; 2005 Dec; 88(2); 400-411

Kim SY, Suzuki N, Laxmi YR, McGarrigle BP, Olson JR, Sharma M, Sharma M, Shibutani S; Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen.; Chem Res Toxicol; 2005 May; 18(5); 889-895

Bloom MS, Vena JE, Swanson MK, Moysich KB, Olson JR; Profiles of ortho-polychlorinated biphenyl congeners, dichlorodiphenyldichloroethylene, hexachlorobenzene, and Mirex among male Lake Ontario sportfish consumers: the New York State Angler cohort study.; Environ Res; 2005 Feb; 97(2); 178-194

Vezina CM, Walker NJ, Olson JR; Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.; Environ Health Perspect; 2004 Nov; 112(16); 1636-1644

Harrigan JA, Vezina CM, McGarrigle BP, Ersing N, Box HC, Maccubbin AE, Olson JR; DNA adduct formation in precision-cut rat liver and lung slices exposed tobenzo[a]pyrene.; Toxicol Sci; 2004 Feb; 77(2); 307-314

Sharma M, Shubert DE, Sharma M, Lewis J, McGarrigle BP, Bofinger DP, Olson JR; Biotransformation of tamoxifen in a human endometrial explant culture model.; Chem Biol Interact; 2003 Dec; 146(3); 237-249

Sharma M, Shubert DE, Sharma M, Rodabaugh KJ, McGarrigle BP, Vezina CM, Bofinger DP, Olson JR; Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture.; Biochem Biophys Res Commun; 2003 Jul; 307(1); 157-164

Vezina, CM and Olson JR; Comparison of the Hepatic Gene Expression Profiles in Female Rats Exposed Subchronically to TCDD, PeCDF, PCB126 and PCB153 Using DNA Microarray; Organohalogen Compounds; 2003; 64; 339-341

Olson, JR, Vezina, CM, Malek, RL, Sajadi, H, Lee, NH, Luu, TV, and Wang, H; Temporal Changes in the Hepatic Gene Expression Profiles of Female Rats Exposed to TCDD, PeCDF, PCB126, and PCB153 for 14 or 53 Weeks.; Organohalogen Compounds; 2003; 64; 267-269

Germaine Buck, John Vena, Hebe Greizerstein, John Weiner, Bridget McGuinness, Pauline Mendola, Paul Kostyniak, Mya Swanson, Michael Bloom, James Olson; PCB congeners and pesticides and female fecundity, New York State Angler Propective Pregnancy Study; Environmental Toxicology and Pharmacology; 2002 Aug; 12; 83-92

Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR; Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant culturesof human endometrium.; Toxicol Sci; 2001 Aug; 62(2); 299-314

Schecter, A, Cramer, P, Boggess, K, Stanley, J, Papke, O, James Olson, Sliver, A, Schmits, M; Intake of Dioxins and Related Compounds from Food in the U.S. Population; Journal of Toxicology and Environmental Health Part A; 2001 May; 63; 101-118

Honey S, O‘Keefe P, Drahushuk AT, Olson JR, Kumar S, Sikka HC; Metabolism of benzo(a)pyrene by duck liver microsomes.; Comp Biochem Physiol C Toxicol Pharmacol; 2000 Jul; 126(3); 285-292

Buck GM, John Vena, Schisterman EF, Jacek Dmochowski, Mendola P, Sever LE, Fitzgerald E, Paul Kostyniak, Greizerstein H, James Olson; Parental consumption of contaminated sport fish from Lake Ontario and predicted fecundability.; Epidemiology; 2000 Jul; 11(4); 388-393

Drahushuk AT, McGarrigle BP, Slezak BP, Stegeman JJ, Olson JR; Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin.; Toxicol Appl Pharmacol; 1999 Mar; 155(2); 127-138

Buck, GM, Mendola, P, John Vena, Sever, LE, Paul Kostyniak, Greizerstein, H, James Olson, Stephen, FD; Paternal Lake Ontario Fish Consumption and Risk of Conception Delay, New York State Angler Cohort; Environmental Research; 1999 Feb; 80; S13-S18

Schecter, A, Dellarco, M, Papke, O, James Olson; A Comparison of Dioxins, Dibenzofurans, and Coplanar PCBs in Uncooked and Broiled Ground Beef, Catfish, and Bacon; Chemosphere; 1998 Oct; 37; 1723-1730

Drahushuk AT, McGarrigle BP, Larsen KE, Stegeman JJ, Olson JR; Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture.; Carcinogenesis; 1998 Aug; 19(8); 1361-1368

Pelosi, GD, Oberdoerster, J, James Olson, Knaak, JB, Smith, LW, Newton, PE; Characterization of Rat Hepatic Cytochrome P450 Activities Following Inhalation Exposure to p-Chlorobenzotrifluoride (PCBTF); Inhalation Toxicology; 1998 Jan; 10; 49-63

Knaak, JB, Smith, LW, Fitzpatrick, RD, James Olson, Newton, PE; In Vitro Hepatic Metabolism of PCBTF: Development of Vmax, Km Values, Partition Coefficients and Their Use in an Inhalation PBPK Model; Inhalation Toxicology; 1998 Jan; 10; 65-85

Stephen FD, Drahushuk AT, Olson JR; Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C.; Toxicology; 1997 Dec; 124(1); 39-51

Drahushuk AT, Choy CO, Kumar S, McReynolds JH, Olson JR; Modulation of cytochrome P450 by 5,5‘-bis-trifluoromethyl-2,2‘-dichlorobiphenyl,a unique environmental contaminant.; Toxicology; 1997 Jul; 120(3); 197-205

Geyer HJ, Schramm KW, Scheunert I, Schughart K, Buters J, Wurst W, Greim H, Kluge R, Steinberg CE, Kettrup A, Madhukar B, Olson JR, Gallo MA; Considerations on genetic and environmental factors that contribute to resistanceor sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)and related compounds.; Ecotoxicol Environ Saf; 1997 Apr; 36(3); 213-230

Schecter A, Olson JR; Cancer risk assessment using blood dioxin levels and daily dietary TEQ intakein general populations of industrial and non-industrial countries.; Chemosphere; 1997 Mar; 34(5-7); 1569-1577

Schecter A, Cramer P, Boggess K, Stanley J, Olson JR; Levels of dioxins, dibenzofurans, PCB and DDE congeners in pooled food samplescollected in 1995 at supermarkets across the United States.; Chemosphere; 1997 Mar; 34(5-7); 1437-1447

Drahushuk AT, McGarrigle BP, Tai HL, Kitareewan S, Goldstein JA, Olson JR; Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction.; Toxicol Appl Pharmacol; 1996 Oct; 140(2); 393-403

Schecter A, Papke O, Lis A, Ball M, Ryan JJ, Olson JR, Li L, Kessler H; Decrease in milk and blood dioxin levels over two years in a mother nursing twins: estimates of decreased maternal and increased infant dioxin body burden from nursing.; Chemosphere; 1996 Feb; 32(3); 543-549

John Vena, Buck, GM, Paul Kostyniak, Mendola, P, Fitzgerald, E, Sever, L, Jo Freudenheim, Greizerstein, H, Zielezny, M, McReynolds, J, James Olson; The New York Angler Cohort Study: Exposure Characterization and Reproductive and Developmental Health; Toxicology and Industrial Health; 1996; 12(3/4); 327-334

Fiorella PD, Olson JR, Napoli JL; 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces diverse retinoic acid metabolites in multiple tissues of the Sprague-Dawley rat.; Toxicol Appl Pharmacol; 1995 Oct; 134(2); 222-228

Schecter A, Startin J, Wright C, Kelly M, Päpke O, Lis A, Ball M, Olson JR; Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimateddaily dioxin toxic equivalent intake.; Environ Health Perspect; 1994 Nov; 102(11); 962-966

Olson JR, McGarrigle BP, Gigliotti PJ, Kumar S, McReynolds JH; Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran.; Fundam Appl Toxicol; 1994 May; 22(4); 631-640

Van den Berg M, De Jongh J, Poiger H, Olson JR; The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs)and dibenzofurans (PCDFs) and their relevance for toxicity.; Crit Rev Toxicol; 1994; 24(1); 1-74

Tai HL, McReynolds JH, Goldstein JA, Eugster HP, Sengstag C, Alworth WL, Olson JR; Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human.; Toxicol Appl Pharmacol; 1993 Nov; 123(1); 34-42

Nosek JA, Craven SR, Sullivan JR, Olson JR, Peterson RE; Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in ring-necked pheasant hens, chicks, and eggs.; J Toxicol Environ Health; 1992 Mar; 35(3); 153-164

Walker, MK, Spitsbergen, JM, James Olson, Peterson, RE; 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity during early life stage development of lake trout; Can J Fish Aquat Sci; 1991 May; 48; 875-883

Shen ES, Gutman SI, Olson JR; Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated hepatotoxicity inC57BL/6J and DBA/2J mice.; J Toxicol Environ Health; 1991 Apr; 32(4); 367-381

Spitsbergen, JM, James Olson, Walker, MK, Peterson, RE; Pathologic lesions in early life stages of lake trout, Salvelinus namaycush, exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin as fertilized eggs; Aquatic Toxicol; 1991 Feb; 19; 41-72

James Olson, McGarrigle, BP; Comparative Developmental Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); Chemosphere; 1991; 25; 71-74

James Olson, McGarrigle, BP, Tonucci, DA, Schecter, A, Eichelberger, H; Developmental Toxicology of 2,3,7,8-TCDD in the rat and hamster; Chemosphere; 1990; 20; 1117-1123

Aleo, MD, Mary Taub, James Olson, Paul Kostyniak; Primary cultures of rabbit renal tubule cells: II. Selected phase I and phase II metabolic capacities; Toxicol In Vitro; 1990; 4; 727-733

Shen ES, Guengerich FP, Olson JR; Biphasic response for hepatic microsomal enzyme induction by 2,3,7,8-tetrachlorodibenzo-p-dioxinin C57BL/6J and DBA/2J mice.; Biochem Pharmacol; 1989 Nov; 38(22); 4075-4084

Hruska RE, Olson JR; Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.; Toxicol Lett; 1989 Sep; 48(3); 289-299

Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Roth JA; Effect of chronic exposure to hexachlorophene on rat brain cell specific marker enzymes.; Neurotoxicology; 1989 Jun; 10(2); 201-210

Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth JA; Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to methylmercury.; Neurotoxicology; 1989 Jan; 10(1); 41-52

James Olson, Bellin, JS, Barnes, DG; Reexamination of data used for establishing Toxicity Equivalence Factors (TEFs) for Chlorinated Dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs); Chemosphere; 1989; 18; 371-381

James Olson, Gutman, SI, Shen, ES; Reexamination of the dose-response relationship for induction of the hepatic monooxygenase system by 2,3,7,8-TCDD; Chemosphere; 1989; 18; 363-370

Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA; Effect of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes.; Fundam Appl Toxicol; 1988 Oct; 11(3); 519-527

Wroblewski VJ, Gessner T, Olson JR; Qualitative and quantitative differences in the induction and inhibition ofhepatic benzo[a]pyrene metabolism in the rat and hamster.; Biochem Pharmacol; 1988 Apr; 37(8); 1509-1517

Kleeman JM, Olson JR, Peterson RE; Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformationin fish.; Fundam Appl Toxicol; 1988 Feb; 10(2); 206-213

Wroblewski VJ, Olson JR; Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster.; Drug Metab Dispos; 1988 Jan; 16(1); 43-51

Wroblewski VJ, Olson JR; Effect of monooxygenase inducers and inhibitors on the hepatic metabolism of2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat and hamster.; Drug Metab Dispos; 1988 Jan; 16(1); 43-51

Shen ES, Olson JR; Relationship between the murine Ah phenotype and the hepatic uptake and metabolismof 2,3,7,8-tetrachlorodibenzo-p-dioxin.; Drug Metab Dispos; 1987 Sep; 15(5); 653-660

Kung MP, Kostyniak P, Olson J, Malone M, Roth JA; Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes.; J Appl Toxicol; 1987 Apr; 7(2); 119-121

Olson JR; Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in guinea pigs.; Toxicol Appl Pharmacol; 1986 Sep; 85(2); 263-273

Kleeman JM, Olson JR, Chen SM, Peterson RE; 2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch.; Toxicol Appl Pharmacol; 1986 May; 83(3); 402-411

Kleeman JM, Olson JR, Chen SM, Peterson RE; Metabolism and disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rainbow trout.; Toxicol Appl Pharmacol; 1986 May; 83(3); 391-401

Wroblewski VJ, Olson JR; Hepatic metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and guinea pig.; Toxicol Appl Pharmacol; 1985 Nov; 81(2); 231-240

James Olson, Wroblewski, VJ; Metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in isolated hepatocytes from guinea pigs and rats; Chemosphere; 1985 Nov; 14; 979-982

Sawahata T, Olson JR, Neal RA; Identification of metabolites of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin (TCDD) formed on incubation with isolated rat hepatocytes.; Biochem Biophys Res Commun; 1982 Mar; 105(1); 341-346

Neal RA, Olson JR, Gasiewicz TA, Geiger LE; The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems.; Drug Metab Rev; 1982; 13(3); 355-385

Olson JR, Gasiewicz TA, Neal RA; Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.; Toxicol Appl Pharmacol; 1980 Oct; 56(1); 78-85

Olson JR, Holscher MA, Neal RA; Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster.; Toxicol Appl Pharmacol; 1980 Aug; 55(1); 67-78

Jansen MA, Olson JR, Fujimoto JM; Taurolithocholate-induced increase in the intrabiliary pressure generated during retrograde intrabiliary infusion of saline in rats: antagonism by taurocholate and glycocholate.; Toxicol Appl Pharmacol; 1980 Jun; 54(1); 9-19

Olson JR, Fujimoto JM; Demonstration of a D-glucose transport system in the biliary tree of the rat by use of the segmented retrograde intrabiliary injection technique.; Biochem Pharmacol; 1980 Feb; 29(2); 213-219

Olson JR, Fujimoto JM; Evaluation of hepatobiliary function in the rat by the segmented retrograde intrabiliary injection technique.; Biochem Pharmacol; 1980 Feb; 29(2); 205-211

Olson JR, Hosko MJ, Fujimoto JM; Alterations in the liver cell transmembrane potential following CC14 and bile salt treatment of rats.; Life Sci; 1979 Dec; 25(24-25); 2043-2050

Olson JR, Fujimoto JM, Peterson RE; Three methods for measuring the increase in the capacity of the distended biliary tree in the rat produced by alpha-naphthylisothiocyanate treatment.; Toxicol Appl Pharmacol; 1977 Oct; 42(1); 33-43

Peterson RE, Olson JR, Fujimoto JM; Measurement and alteration of the capacity of the distended biliary tree in the rat.; Toxicol Appl Pharmacol; 1976 May; 36(2); 353-368

GRANTS

June 2008 to May 2012 Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity NIEHS Co-investigators Matthew Bonner, James Knaak $777,129

September 2007 to August 2010 CYP-Specific PBPK/PD Models to Interpret Biomarkers for Organophosphate Pesticides US EPA Co-investigators: Richard Browne, Matthew Bonner, James Knaak, Paul Kostyniak, Aiming Yu $749,722

March 2007 to February 2008 Research Reagents for Human Serum Paraoxonase 1 NYSTAR Technology Transfer Incentive Program Principal Investigator Richard Browne Co-investigators KR Olson and JR Olson

December 2006 to November 2008 Dietary Isothiocyanates in Cancer Prevention: Effects on Estrogen NCI Principle Investigator Marilyn Morris Co-investigator James R. Olson

June 2004 to March 2007 Identification of functional peptide ligands for the AhR NIEHS Principle Investigator: James R. Olson Co-investigator: Kate Rittenhouse-Olson

October 2003 to September 2007 University-Community Consortium for Anniston Environmental Health Research ATSDR/CDC James Olson, PI Ling Bian & Peter Rogerson, Co-I

February 2003 to December 2006 Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans U.S. EPA Principle Investigator: James R. Olson Co-Investigators: James B. Knaak and Paul Kostyniak