Dr. Ronald Rubin
Pharmacology And Toxicology
Professor
102 Farber Hall
Buffalo NY, 14214
Phone: (716) 829-2800
Email: rprubin@buffalo.edu

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OFFICE LOCATIONS

Office Location
102 Farber Hall
Buffalo NY, 14214

Phone: 716-829-3048
Fax: 716-829-2801
Email: rprubin@acsu.buffalo.edu
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DESCRIPTION OF INTERESTS

The parotid acinar cell is a morphologically and functionally polarized epithelial cell whose major function is to synthesize and secrete amylase at the apical pole and cations and fluid across the basolateral membrane. The rat parotid gland has been extensively employed as an experimental model for studying agonist-activated ionic events and exocytotic protein and water secretion. Since stimulation of calcium mobilization is one of the key events in signal translation, we are investigating the mechanism of calcium signaling in parotid acinar cells and the relative roles of the inositol 1,4,5-triphosphate (IP3) and ryanodine receptor systems in this process. Since ryanodine receptors have been integrated into proposed models of IP3-induced calcium signalling, specific knowledge of the cellular localization and expression
of the IP3 and ryanodine receptors will help to determine the nature of the interactions between these two systems and define their specific roles in signal transduction.


SPECIALTIES

Cell growth, development and Virology differentiation
Endocrinology
Ion channel kinetics and structure
Molecular and Cellular Biology
Signal Transduction


EDUCATION

1963 PhD, Pharmacology
Albert Einstein College of Medicine
1958 Master of Arts in Teaching, Science Education
Harvard Graduate School of Education
1954 AB, Biochemistry
Harvard University


EXPERTISE

Signal Transduction in Exocrine Cells


PUBLICATIONS

Takeuchi T, Aletta JM, Laychock SG, Tian Y, Rubin RP; Role of nerve growth factor in the regulation of parotid cell differentiation induced by rat serum.; Biochem Pharmacol; 2003 May; 65(9); 1507-1513
Takeuchi T, Aletta JM, Laychock SG, Tian Y, Rubin RP; Role of nerve growth factor in the regulation of parotid cell differentiation induced by rat serum.; Biochem Pharmacol; 2003 May; 65(9); 1507-1513
Takeuchi, T., Aletta J, Laychock S, Tian, Y., Rubin R; Biochem. Pharmacol. 65: 1507-1513 (2003).; 2003;
Takeuchi, T., Aletta J, Laychock S, Tian, Y., Rubin R; Role of nerve growth factor in the regulation of parotid cell differentiation induced by rat serum; Biochem. Pharmacol. 65: 1507-1513 (2003); 2003;
Lee, B.S., Sessanna, S., Laychock, S.G., & Rubin, R.P.; Expression and Cellular Localization of a Modified Type 1 Ryanodine Receptor and L-Type Channel Proteins in Non-Muscle Cells; J. Membrane Biol. 189: 181-190 (2002); 2002; 189; 181-190
Zhang X, Wen J, Bidasee KR, Besch HR, Wojcikiewicz RJ, Lee B, Rubin RP; Ryanodine and inositol trisphosphate receptors are differentially distributed and expressed in rat parotid gland.; Biochem J; 1999 Jun; 340 (; 519-527
Zhu Y, Aletta JM, Wen J, Zhang X, Higgins D, Rubin RP; Rat serum induces a differentiated phenotype in a rat parotid acinar cell line.; Am J Physiol; 1998; 275(2); 259-268
Zhang X, Wen J, Bidasee KR, Besch HR, Rubin RP; Ryanodine receptor expression is associated with intracellular Ca2+ release in rat parotid acinar cells.; Am J Physiol; 1997 Oct; 273(4 Pt); 1306-1314
Zhang X, Wen J, Aletta JM, Rubin RP; Inhibition of expression of PKC-alpha by antisense mRNA is associated with diminished cell growth and inhibition of amylase secretion by AR4-2J cells.; Exp Cell Res; 1997 May; 233(1); 225-231
Terzian AR, Zhang X, Rubin RP; Differential modulation of protein kinase C isozymes in rat parotid acinar cells. Relation to amylase secretion.; Biochem Pharmacol; 1996 Aug; 52(4); 569-577
Koshlukova S, Rubin RP, Withiam-Leitch M, Aletta JM; Epidermal growth factor induces the differential release of GP2 and amylase from AR4-2J cells.; Cell Signal; 1995 Aug; 7(6); 559-569
Withiam-Leitch M, Rubin RP, Koshlukova SE, Aletta JM; Identification and characterization of carboxyl ester hydrolase as a phospholipid hydrolyzing enzyme of zymogen granule membranes from rat exocrine pancreas.; J Biol Chem; 1995 Feb; 270(8); 3780-3787
Rubin RP, Adolf MA; Cyclic AMP regulation of calcium mobilization and amylase release from isolated permeabilized rat parotid cells.; J Pharmacol Exp Ther; 1994 Feb; 268(2); 600-606
Terzian AR, Rubin RP; Translocation of the alpha-isozyme of protein kinase C during stimulation of rat parotid acinar cells by phorbol ester and carbachol.; Arch Oral Biol; 1993 Dec; 38(12); 1051-1056
Withiam-Leitch M, Aletta JM, Koshlukova SE, Rupp G, Beaudoin AR, Rubin RP; Glycoprotein 2 of zymogen granule membranes shares immunological cross-reactivity and sequence similarity with phospholipase A2.; Biochem Biophys Res Commun; 1993 Aug; 194(3); 1167-1174
Conway BR, Withiam-Leitch M, Rubin RP; Regulation of phosphatidylinositol 4-kinase activity in rat pancreatic acini.; Mol Pharmacol; 1993 Feb; 43(2); 286-292
Hundley TR, Rubin RP; Carbachol stimulation of triacylglycerol lipase activity in pancreatic acinar cells.; Biochem Biophys Res Commun; 1992 Apr; 184(2); 626-633
Rubin RP, Hundley TR, Adolf MA; Regulation of diacylglycerol levels in carbachol-stimulated pancreatic acinar cells: relationship to the breakdown of phosphatidylcholine and metabolism to phosphatidic acid.; Biochim Biophys Acta; 1992 Jan; 1133(2); 127-132
Conway BR, Laychock SG, Rubin RP; Comparative effects of epidermal growth factor and carbachol on phosphoinositide synthesis and breakdown in pancreatic acinar cells.; Biochem Biophys Res Commun; 1991 Jul; 178(2); 780-785
Komabayashi T, Yakata A, Izawa T, Suda K, Rubin RP, Tsuboi M; Protein kinase C-dependent diacylglycerol formation is mediated via Ca2+/calmodulin in parotid cells.; Eur J Pharmacol; 1991 Jul; 207(3); 175-181
Rubin RP, Withiam-Leitch M, Laychock SG; Modulation of phospholipase A2 activity in zymogen granule membranes by GTP[S]; evidence for GTP-binding protein regulation.; Biochem Biophys Res Commun; 1991 May; 177(1); 22-26
Rubin RP, Thompson RH, Naps MS; Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils.; Agents Actions; 1990 Nov; 31(3-4); 237-242
Komabayashi T, McKinney JS, Rubin RP; Regulation by diacylglycerol of calcium-evoked amylase secretion from intact and permeabilized pancreatic acinar cells.; Cell Calcium; 1990 Sep; 11(8); 501-506
Rubin RP, Thompson RH, Laychock SG; Characterization of phospholipase A2 and acyltransferase activities in purified zymogen granule membranes.; Biochim Biophys Acta; 1990 Aug; 1045(3); 245-251
Chaudhry A, Rubin RP; Mediators of Ca2(+)-dependent secretion.; Environ Health Perspect; 1990 Mar; 84; 35-39
Neu HC, Bennett JE, Bodey GP, Rubin RH, Schentag JJ, Sugar AM; P&T Committee review of fluconazole: an effective alternative to antifungal therapy.; Hosp Formul; 1990 Mar; 25 Su; 9-14
McKinney JS, Desole MS, Rubin RP; Convergence of cAMP and phosphoinositide pathways during rat parotid secretion.; Am J Physiol; 1989 Oct; 257(4 Pt); 651-657
Chaudhry A, Conway BR, Laychock SG, Rubin RP; Analysis of the regulation of phosphatidylinositol-4,5-bisphosphate synthesis by arachidonic acid in exocrine pancreas.; Arch Biochem Biophys; 1989 Aug; 272(2); 488-495
McKinney JS, Rubin RP; Enhancement of cyclic AMP modulated salivary amylase secretion by protein kinase C activators.; Biochem Pharmacol; 1988 Dec; 37(23); 4433-4438
Chaudhry A, Thompson RH, Rubin RP, Laychock SG; Relationship between delta-9-tetrahydrocannabinol-induced arachidonic acid release and secretagogue-evoked phosphoinositide breakdown and Ca2+ mobilization of exocrine pancreas.; Mol Pharmacol; 1988 Oct; 34(4); 543-548
Chaudhry A, Laychock SG, Rubin RP; The effects of fatty acids on phosphoinositide synthesis and myo-inositol accumulation in exocrine pancreas.; J Biol Chem; 1987 Dec; 262(36); 17426-17431
Bradford PG, Rubin RP; Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils.; J Biol Chem; 1986 Nov; 261(33); 15644-15647
Bradford PG, Rubin RP; Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations.; Biochem J; 1986 Oct; 239(1); 97-102
Taylor CW, Merritt JE, Putney JW, Rubin RP; Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.; Biochem J; 1986 Sep; 238(3); 765-772
Merritt JE, Taylor CW, Rubin RP, Putney JW; Isomers of inositol trisphosphate in exocrine pancreas.; Biochem J; 1986 Sep; 238(3); 825-829
Merritt JE, Taylor CW, Rubin RP, Putney JW; Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.; Biochem J; 1986 Jun; 236(2); 337-343
Taylor CW, Merritt JE, Putney JW, Rubin RP; A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland.; Biochem Biophys Res Commun; 1986 Apr; 136(1); 362-368
Spät A, Fabiato A, Rubin RP; Binding of inositol trisphosphate by a liver microsomal fraction.; Biochem J; 1986 Feb; 233(3); 929-932
Spät A, Bradford PG, McKinney JS, Rubin RP, Putney JW; A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils.; Nature; 1986; 319; 514
Merritt JE, Rubin RP; Pancreatic amylase secretion and cytoplasmic free calcium. Effects of ionomycin, phorbol dibutyrate and diacylglycerols alone and in combination.; Biochem J; 1985 Aug; 230(1); 151-159
Bradford PG, Rubin RP; Pertussis toxin inhibits chemotactic factor-induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils.; FEBS Lett; 1985 Apr; 183(2); 317-320
Bradford PG, Rubin RP; Characterization of formylmethionyl-leucyl-phenylalanine stimulation of inositol trisphosphate accumulation in rabbit neutrophils.; Mol Pharmacol; 1985 Jan; 27(1); 74-78
Rubin RP; Stimulation of inositol trisphosphate accumulation and amylase secretion by caerulein in pancreatic acini.; J Pharmacol Exp Ther; 1984 Dec; 231(3); 623-627
Kramer CM, Franson RC, Rubin RP; Regulation of phosphatidylinositol turnover, calcium metabolism and enzyme secretion by phorbol dibutyrate in neutrophils.; Lipids; 1984 May; 19(5); 315-323
Rubin RP, Godfrey PP, Chapman DA, Putney JW; Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate.; Biochem J; 1984 Apr; 219(2); 655-659
Putney JW, Burgess GM, Halenda SP, McKinney JS, Rubin RP; Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas.; Biochem J; 1983 May; 212(2); 483-488
Rubin RP; Acyltransferase-catalyzed transfer of arachidonic acid to lysophospholipids in rat pancreatic acini.; Biochem Biophys Res Commun; 1983 Apr; 112(2); 502-507
Halenda SP, Rubin RP; Phospholipid turnover in isolated rat pancreatic acini. Consideration of the relative roles of phospholipase A2 and phospholipase C.; Biochem J; 1982 Dec; 208(3); 713-721
Rubin RP, Kelly KL, Halenda SP, Laychock SG; Arachidonic acid metabolism in rat pancreatic acinar cells: calcium-mediated stimulation of the lipoxygenase system.; Prostaglandins; 1982 Aug; 24(2); 179-193
Rubin RP; Calcium-phospholipid interactions in secretory cells: a new perspective on stimulus-secretion coupling.; Fed Proc; 1982 Apr; 41(6); 2181-2187
Garcia R, Laychock SG, Rubin RP; Inhibition of dibutyryl cyclic AMP induced steroidogenesis in rat adrenocortical cells by the putative calcium antagonist TMB-8.; J Steroid Biochem; 1982 Feb; 16(2); 317-322
Rubin RP, Sink LE, Freer RJ; Activation of (arachidonyl) phosphatidylinositol turnover in rabbit neutrophils by the calcium ionophore A23187.; Biochem J; 1981 Feb; 194(2); 497-505
Rubin RP, Sink LE, Freer RJ; On the relationship between formylmethionyl-leucyl-phenylalanine stimulation of arachidonyl phosphatidylinositol turnover and lysosomal enzyme secretion by rabbit neutrophils.; Mol Pharmacol; 1981 Jan; 19(1); 31-37
Carchman RA, Shen JC, Bilgin S, Rubin RP; Diverse effects of Ca2+ on the prostacyclin and corticotropin modulation of adenosine 3': 5'-monophosphate and steroid production in normal cat and mouse tumor cells of the adrenal cortex.; Biochem Pharmacol; 1980 Aug; 29(16); 2213-2218
Schrey MP, Rubin RP; Characterization of a calcium-mediated activation of arachidonic acid turnover in adrenal phospholipids by corticotropin.; J Biol Chem; 1979 Nov; 254(22); 11234-11241
Laychock SG, Harada E, Rubin RP; Isoproterenol and nucleotide induced stimulation of Ca2+ uptake by microsomal fractions from kidney and isolated glomeruli.; Biochem Pharmacol; 1979 Nov; 28(21); 3205-3211
Rubin RP, Sink LE, Schrey MP, Day AR, Liao CS, Freer RJ; Secretagogues for lysosomal enzyme release as stimulants of arachidonyl phosphatidylinositol turnover in rabbit neutrophils.; Biochem Biophys Res Commun; 1979 Oct; 90(4); 1364-1370
Harada E, Lester GE, Rubin RP; Stimulation of renin secretion from the intact kidney and from isolated glomeruli by the calcium ionophore A23187.; Biochim Biophys Acta; 1979 Feb; 583(1); 20-27
Ellis EF, Shen JC, Schrey MP, Carchman RA, Rubin RP; Prostacyclin: a potent stimulator of adrenal steroidogenesis.; Prostaglandins; 1978 Oct; 16(4); 483-490
Harada E, Laychock SG, Rubin RP; Parathyroid hormone induced stimulation of calcium uptake by renal microsomes.; Biochem Biophys Res Commun; 1978 Sep; 84(2); 396-402
Rubin RP, Laychock SG; Prostaglandins and calcium-membrane interactions in secretory glands.; Ann N Y Acad Sci; 1978 Apr; 307; 377-390
Laychock SG, Shen JC, Carmines EL, Rubin RP; The effect of corticotropin on phospholipid metabolism in isolated adrenocortical cells.; Biochim Biophys Acta; 1978 Mar; 528(3); 355-363
Harada E, Rubin RP; Stimulation of renin secretion and calcium efflux from the isolated perfused cat kidney by noradrenaline after prolonged calcium deprivation.; J Physiol; 1978 Jan; 274; 367-379
Lester GE, Rubin RP; The role of calcium in renin secretion from the isolated perfused cat kidney.; J Physiol; 1977 Jul; 269(1); 93-108
Laychock SG, Franson RC, Weglicki WB, Rubin RP; Identification and partial characterization of phospholipases in isolated adrenocortical cells. The effects of synacthen [corticotropin-(1--24)-tetracosapeptide] and calcium ions.; Biochem J; 1977 Jun; 164(3); 753-756
Laychock SG, Rubin RP; Regulation of steroidogenesis and prostaglandin formation in isolated adrenocortical cells: the effects of pregnenolone and cycloheximide.; J Steroid Biochem; 1977 Jun; 8(6); 663-667
Rubin RP, Laychock SG, End DW; On the role of cyclic AMP and cyclic GMP in steroid production by bovine cortical cells.; Biochim Biophys Acta; 1977 Feb; 496(2); 329-338
Laychock SG, Warner W, Rubin RP; Further studies on the mechanisms controlling prostaglandin biosynthesis in the cat adrenal cortex: the role of calcium and cyclic AMP.; Endocrinology; 1977 Jan; 100(1); 74-81
Gemmell RT, Laychock SG, Rubin RP; Ultrastructural and biochemical evidence for a steroid-containing secretory organelle in the perfused cat adrenal gland.; J Cell Biol; 1977 Jan; 72(1); 209-215
Laychock SG, Rubin RP; Indomethacin-induced alterations in corticosteroid and prostaglandin release by isolated adrenocortical cells of the cat.; Br J Pharmacol; 1976 Jun; 57(2); 273-278
Laychock SG, Rubin RP; Radioimmunoassay measurement of ACTH-facilitated PGE2 and PGF2alpha release from isolated cat adrenocortical cells.; Prostaglandins; 1976 Apr; 11(4); 753-767
Laychock SG, Rubin RP; ACTH-induced prostaglandin biosynthesis from 3H-arachidonic acid by adrenocortical cells.; Prostaglandins; 1975 Sep; 10(3); 529-540
Rubin RP, Warner W; Nicotine-induced stimulation of steroidogenesis in adrenocortical cells of the cat.; Br J Pharmacol; 1975 Mar; 53(3); 357-362
Warner W, Rubin RP; Evidence for a possible prostaglandin link in ACTH-induced steroidogenesis.; Prostaglandins; 1975 Jan; 9(1); 83-95
Rubin RP, Sheid B, McCauley R, Laychock SG; ACTH-induced protein release from the perfused cat adrenal gland: evidence for exocytosis?; Endocrinology; 1974 Aug; 95(2); 370-378
Laychock SG, Rubin RP; Isolation of ACTH-induced protein from adrenal perfusate.; Steroids; 1974 Aug; 24(2); 177-184
Jaanus SD, Rubin RP; Analysis of the role of cyclic adenosine 3',5'-monophosphate in catecholamine release.; J Physiol; 1974 Mar; 237(2); 465-476
Rubin RP, Jaanus SD, Carchman RA, Puig M; Reversible inhibition of ACTH-induced corticosteroid release by cycloheximide: evidence for an unidentified cellular messenger.; Endocrinology; 1973 Sep; 93(3); 575-580
Rubin RP, Carchman RA, Jaanus SD; Role of calcium and adenosine cyclic 3'-5' phosphate in action of adrenocorticotropin.; Nat New Biol; 1972 Nov; 240(100); 150-152
Jaanus SD, Carchman RA, Rubin RP; Further studies on the relationship between cycl AMP levels and adrenocortical activity.; Endocrinology; 1972 Oct; 91(4); 887-895
Rubin RP, Carchman RA, Jaanus SD; Role of cyclic 3'5' adenosine monophosphate on corticosteroid synthesis and release from the intact adrenal gland.; Biochem Biophys Res Commun; 1972 Jun; 47(6); 1492-1497
Carchman RA, Jaanus SD, Rubin RP; The role of adrenocorticotropin and calcium in adenosine cyclic 3', 5'-phosphate production and steroid release from the isolated, perfused cat adrenal gland.; Mol Pharmacol; 1971 Sep; 7(5); 491-499
Jaanus SD, Rubin RP; The effect of ACTH on calcium distribution in the perfused cat adrenal gland.; J Physiol; 1971 Mar; 213(3); 581-598
Rubin RP; The role of calcium in the release of neurotransmitter substances and hormones.; Pharmacol Rev; 1970 Sep; 22(3); 389-428
Jaanus SD, Rosenstein MJ, Rubin RP; On the mode of action of ACTH on the isolated perfused adrenal gland.; J Physiol; 1970 Aug; 209(3); 539-556
Rubin RP; The role of energy metabolism in calcium-evoked secretion from the adrenal medulla.; J Physiol; 1970 Jan; 206(1); 181-192
Rubin RP, Jaanus SD, Miele E; Calcium dependent corticosteroid release from the perfused cat adrenal gland.; Experientia; 1969 Dec; 25(12); 1327-1328
Rubin RP; The metabolic requirements from catecholamine release from the adrenal medulla.; J Physiol; 1969 May; 202(1); 197-209
Rubin RP, Miele E; A study of the differential secretion of epinephrine and norepinephrine from the perfused cat adrenal gland.; J Pharmacol Exp Ther; 1968 Nov; 164(1); 115-121
Miele E, Rubin RP; Secretion of adrenaline and noradrenaline from the perfused cat adrenal gland.; Br J Pharmacol; 1968 Nov; 34(3); 691-691
Rubin RP, Cohen MS, Harman SM, Roer EM; The localization of adrenaline-rich medullary chromaffin cells adjacent to the adrenal cortex.; J Endocrinol; 1968 Aug; 41(4); 541-545
Jaanus SD, Miele E, Rubin RP; The action of guanethidine on the adrenal medulla of the cat.; Br J Pharmacol; 1968 Jul; 33(3); 560-569
Miele E, Rubin RP; Further evidence for the dual action of local anesthetics on the adrenal medulla.; J Pharmacol Exp Ther; 1968 Jun; 161(2); 296-301
Rubin RP, Feinstein MB, Jaanus SD, Paimre M; Inhibition of catecholamine secretion and calcium exchange in perfused cat adrenal glands by tetracaine and magnesium.; J Pharmacol Exp Ther; 1967 Mar; 155(3); 463-471
Douglas WW, Poisner AM, Rubin RP; Efflux of adenine nucleotides from perfused adrenal glands exposed to nicotine and other chromaffin cell stimulants.; J Physiol; 1965 Jul; 179(1); 130-137
Li V, Rubin R;
Rubin RP, Jaanus SD; A study of the release of catecholamines from the adrenal medulla by indirectly acting sympathomimetic amines.; Naunyn Schmiedebergs Arch Pharmakol Exp Pathol 254: 125-137, 1966;
Schrey MP, Rubin RP; Activation of arachidonic acid turnover in adrenal phospholipids by ACTH, A23187, and Ca2+.; Adv Prostaglandin Thromboxane Res 6: 239-241, 1980;
W.W. Douglas, A.M. Poisner, R.P. Rubin; Efflux of adenine nucleotides from perfused adrenal glands exposed to nicotine and other chromaffin cell stimulants; J. Physiol. 179: 130-137, 1966;
Bradford PG, Rubin RP; Leukotriene B4 stimulates phospholipase-C-mediated formation of inositol trisphosphate in neutrophils: implications for convergence of the phospholipase A2 and C pathways.; Adv Prostaglandin Thromboxane Leukot Res 15: 105-108, 1985;
Douglas WW, Rubin RP; Mechanism of nicotinic action at the adrenal medulla: calcium as a link in stimulus-secretion coupling.; Nature 192: 1087-1089, 1961;
Rubin RP, Jaanus SD; Tachyphylaxis to the stimulant actions of the indirectly acting sympathomimetic amines and acetylcholine on the adrenal medulla.; Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 256: 464-475, 1967;
Bradford PG, Rubin RP; The differential effects of nedocromil sodium and sodium cromoglycate on the secretory response of rabbit peritoneal neutrophils.; Eur J Respir Dis 69: Suppl 147) 238-240, 1986;
W.W. Douglas, R.P. Rubin; The effect of alkali earths and other divalent cations on adrenal medullary secretion; J. Physiol. 175: 231-241, 1965;
Douglas WW, Rubin RP; The mechanism of catectholamine release from the adrenal medulla and the role of calcium in stimulus-secretion coupling.; J. Physiol. 167: 288-310, 1963;
Jaanus SD, Rubin RP; The perfused adrenal gland.; Methods Enzymol 39:328-336, 1975;
Rubin RP, Miele E; The relation between the chemical structure of local anesthetics and inhibition of calcium-evoked secretion from the adrenal medulla.; Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 260: 298-308, 1968;
Rubin RP, Jaanus SD; The release of nucleotide from the adrenal medulla by indirectly acting sympathomimetic amines.; Biochem Pharmacol 16: 1007-1012, 1967;
Douglas WW, Rubin RP; The role of calcium in the secretory response of the adrenal medulla to acetylcholine.; J. Physiol. 159: 40-57, 1961;
Douglas WW, Rubin RP; The stimulant action of barium on the adrenal medulla; Nature 203: 305-307, 1964;


GRANTS


Cellular Pharmacology of Salivary Secretion
NIH-NIDR
Ronald Rubin
$412,231

Phospholipid Turnover in Exocrine Pancreas
NIAMDDKD (NIH)
Rubin, Ronald
$255,619

The Action of Nedocromil Sodium on Secretion
Fisons Pharmaceuticals
Ronald Rubin
$25,000

The Action of Nicotine on the Adrenal Gland
Council for Tobacco Research
Rubin, Ronald

The Mechanism of Action of ACTH on the Adrenal Gland
NIAMDDK (NIH)
Rubin, Ronald

The Role of Calcium in Cellular Secretion
NIDDKD
Ronald Rubin



 
Dr. Ronald Rubin
Dr. Ronald Rubin