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OFFICE LOCATIONS
VA Western New York Healthcare System
3495 Bailey Avenue
Buffalo NY, 14215
Phone: 716-862-7874
Fax: 716-862-6526
Contact: Cookie Thurston
Email: trusso@acsu.buffalo.edu
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Insurance Accepted
Better Health Plan, Inc. (HMO)
Community Blue (HMO)
Empire
Fidelis
GHI
Independent Health Association (HMO)
United Healthcare
Univera Health Care (HMO) |
DESCRIPTION OF INTERESTS
Extraintestinal isolates of Escherichia coli
Urinary tract infection, pulmonary infection, bacteremia
Microbial pathogenesis
Vaccine development
Strains of E. coli that cause disease in humans can be broadly divided into two groups. The first group contains the enteric pathogens and the second group consists of those strains that cause extraintestinal infection. The infectious syndromes due to extraintestinal isolates of E. coli range from uncomplicated cystitis to bacteremia with subsequent septic shock and death. The clinical and economic impact of infectious syndromes caused by this cohort of pathogens is enormous, despite the availability of efficacious antimicrobial therapy. I believe that an understanding of the pathogenic process utilized by these organisms will be critical for the logical development of new preventative and/or therapeutic strategies. Our research goal to identify bacterial determinants and to assess: a) in vitro and in vivo their relative importance in the pathogenesis of infection and b) their potential as vaccine candidates. A bacteremic strain is being used as a model pathogen. A genetic, molecular biology approach is
beingemployed to achieve this goal. Ongoing projects include: 1) identification of genes required for growth and survival in urine and blood, 2) identification of genes induced in vivo, 3) identification of antigenic determinants expressed in vivo, 4) the role of capsular polysaccharide and lipopolysaccharide, and 5) molecular epidemiologic studies of E. coli strains from women with urinary tract infection. |
SPECIALTIES
Infectious Disease
Internal Medicine
Apoptosis and cell death
Bioinformatics
Genomics and proteomics
Immunology
Immunopathology
Microbial Pathogenesis
Molecular and Cellular Biology
Molecular basis of disease and Parasitology
Pathophysiology |
EDUCATION
| 1988 |
Fellowship, Infectious Diseases
Tufts University
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| 1985 |
Residency, Medicine
New England Deaconess Hospital
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| 1982 |
M.D., MD, CM
McGill University
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EXPERTISE
actinomycosis
infections caused by the genera Actinomyces |
Enteric Gram-Negative Bacilli
Infections caused by Gram-negative bacilli |
Host-Pathogen Interactions
Understanding mechanisms by which extraintestinal patghogenic E. coli modify host defenses |
Microbial Pathogenesis
Understanding the mechanisms by which extraintestinal pathogenic E. coli cause disease |
PUBLICATIONS
| Gill SR; Rat Pneumonia and Soft-Tissue Infection Models for the Study of Acinetobacter baumannii biology; Infect. Immun.; 2008; 76; 3577-3586 |
| Russo TA, Beanan JM, Olson R, MacDonald U, Luke NR, Gill SR, Campagnari AA; Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology.; Infect Immun; 2008; 76(8); 3577-3586 |
| Manderscheid PA, Bodkin RP, Davidson BA, Jensen E, Russo TA, Knight PR; Bacterial clearance and cytokine profiles in a murine model of postsurgical nosocomial pneumonia.; Clin Diagn Lab Immunol; 2004 Jul; 11(4); 742-751 |
| Rotta AT, Shiley KT, Davidson BA, Helinski JD, Russo TA, Knight PR; Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance.; Crit Care Med; 2004 Mar; 32(3); 747-754 |
| Johnson JR, Gajewski A, Lesse AJ, Russo TA; Extraintestinal pathogenic Escherichia coli as a cause of invasive nonurinary infections.; J Clin Microbiol; 2003 Dec; 41(12); 5798-5802 |
| Russo TA, McFadden CD, Carlino-MacDonald UB, Beanan JM, Olson R, Wilding GE; The Siderophore receptor IroN of extraintestinal pathogenic Escherichia coli is a potential vaccine candidate.; Infect Immun; 2003 Dec; 71(12); 7164-7169 |
| Russo TA, Davidson BA, Topolnycky DM, Olson R, Morrill SA, Knight PR, Murphy PM; Human neutrophil chemotaxis is modulated by capsule and O antigen from an extraintestinal pathogenic Escherichia coli strain.; Infect Immun; 2003 Nov; 71(11); 6435-6445 |
| Russo TA, Davidson BA, Carlino-MacDonald UB, Helinski JD, Priore RL, Knight PR; The effects of Escherichia coli capsule, O-antigen, host neutrophils, and complement in a rat model of Gram-negative pneumonia.; FEMS Microbiol Lett; 2003 Sep; 226(2); 355-361 |
| Russo TA, Johnson JR; Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem.; Microbes Infect; 2003 Apr; 5(5); 449-456 |
| Russo TA, McFadden CD, Carlino-MacDonald UB, Beanan JM, Barnard TJ, Johnson JR; IroN functions as a siderophore receptor and is a urovirulence factor in an extraintestinal pathogenic isolate of Escherichia coli.; Infect Immun; 2002 Dec; 70(12); 7156-7160 |
| Russo TA, Bartholomew LA, Davidson BA, Helinski JD, Carlino UB, Knight PR, Beers MF, Atochina EN, Notter RH, Holm BA; Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia.; Am J Physiol Lung Cell Mol Physiol; 2002 Sep; 283(3); 655-663 |
| Johnson JR, Russo TA; Uropathogenic Escherichia coli as agents of diverse non-urinary tract extraintestinal infections.; J Infect Dis; 2002 Sep; 186(6); 859-864 |
| Johnson JR, Russo TA; Extraintestinal pathogenic Escherichia coli: 'the other bad E coli'.; J Lab Clin Med; 2002 Mar; 139(3); 155-162 |
| Russo TA, Carlino UB, Johnson JR; Identification of a new iron-regulated virulence gene, ireA, in an extraintestinal pathogenic isolate of Escherichia coli.; Infect Immun; 2001 Oct; 69(10); 6209-6216 |
| Johnson JR, O'Bryan TT, Delavari P, Kuskowski M, Stapleton A, Carlino U, Russo TA; Clonal relationships and extended virulence genotypes among Escherichia coli isolates from women with a first or recurrent episode of cystitis.; J Infect Dis; 2001 May; 183(10); 1508-1517 |
| Johnson JR, Delavari P, Stell AL, Whittam TS, Carlino U, Russo TA; Molecular comparison of extraintestinal Escherichia coli isolates of the same electrophoretic lineages from humans and domestic animals.; J Infect Dis; 2001 Jan; 183(1); 154-159 |
| Johnson JR, O'Bryan TT, Low DA, Ling G, Delavari P, Fasching C, Russo TA, Carlino U, Stell AL; Evidence of commonality between canine and human extraintestinal pathogenic Escherichia coli strains that express papG allele III.; Infect Immun; 2000 Jun; 68(6); 3327-3336 |
| Russo TA, Davidson BA, Priore RL, Carlino UB, Helinski JD, Knight PR; Capsular polysaccharide and O-specific antigen divergently modulate pulmonary neutrophil influx in an Escherichia coli model of gram-negative pneumonitis in rats.; Infect Immun; 2000 May; 68(5); 2854-2862 |
| Johnson JR, Russo TA, Tarr PI, Carlino U, Bilge SS, Vary JC, Stell AL; Molecular epidemiological and phylogenetic associations of two novel putative virulence genes, iha and iroN(E. coli), among Escherichia coli isolates from patients with urosepsis.; Infect Immun; 2000 May; 68(5); 3040-3047 |
| Russo TA, Johnson JR; Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC.; J Infect Dis; 2000 May; 181(5); 1753-1754 |
| Johnson JR, Stell AL, Scheutz F, O'Bryan TT, Russo TA, Carlino UB, Fasching C, Kavle J, Van Dijk L, Gaastra W; Analysis of the F antigen-specific papA alleles of extraintestinal pathogenic Escherichia coli using a novel multiplex PCR-based assay.; Infect Immun; 2000 Mar; 68(3); 1587-1599 |
| Russo TA, Carlino UB, Mong A, Jodush ST; Identification of genes in an extraintestinal isolate of Escherichia coli with increased expression after exposure to human urine.; Infect Immun; 1999 Oct; 67(10); 5306-5314 |
| Luke NR, Thomas Russo, Luther N, Anthony Campagnari; Use of an isogenic mutant constructed in Moraxella catarrhalis To identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6.; Infect Immun; 1999 Feb; 67(2); 681-687 |
| Russo TA, Mylotte D; Expression of the K54 and O4 specific antigen has opposite effects on the bactericidal activity of squalamine against an extraintestinal isolate of Escherichia coli.; FEMS Microbiol Lett; 1998 May; 162(2); 311-315 |
| Johnson JR, Brown JJ, Carlino UB, Russo TA; Colonization with and acquisition of uropathogenic Escherichia coli as revealed by polymerase chain reaction-based detection.; J Infect Dis; 1998 Apr; 177(4); 1120-1124 |
| Russo TA, Wenderoth S, Carlino UB, Merrick JM, Lesse AJ; Identification, genomic organization, and analysis of the group III capsular polysaccharide genes kpsD, kpsM, kpsT, and kpsE from an extraintestinal isolate of Escherichia coli (CP9, O4/K54/H5).; J Bacteriol; 1998 Jan; 180(2); 338-349 |
| Johnson JR, Russo TA, Brown JJ, Stapleton A; papG alleles of Escherichia coli strains causing first-episode or recurrent acute cystitis in adult women.; J Infect Dis; 1998 Jan; 177(1); 97-101 |
| Wang Y, Russo TA, Kwon O, Chanock S, Rumsey SC, Levine M; Ascorbate recycling in human neutrophils: induction by bacteria.; Proc Natl Acad Sci U S A; 1997 Dec; 94(25); 13816-13819 |
| Johnson JR, Stapleton AE, Russo TA, Scheutz F, Brown JJ, Maslow JN; Characteristics and prevalence within serogroup O4 of a J96-like clonal group of uropathogenic Escherichia coli O4:H5 containing the class I and class III alleles of papG.; Infect Immun; 1997 Jun; 65(6); 2153-2159 |
| Johnson JR, Russo TA, Scheutz F, Brown JJ, Zhang L, Palin K, Rode C, Bloch C, Marrs CF, Foxman B; Discovery of disseminated J96-like strains of uropathogenic Escherichia coli O4:H5 containing genes for both PapG(J96) (class I) and PrsG(J96) (class III) Gal(alpha1-4)Gal-binding adhesins.; J Infect Dis; 1997 Apr; 175(4); 983-988 |
| Russo TA, Jodush ST, Brown JJ, Johnson JR; Identification of two previously unrecognized genes (guaA and argC) important for uropathogenesis.; Mol Microbiol; 1996 Oct; 22(2); 217-229 |
| Russo TA, Stapleton A, Wenderoth S, Hooton TM, Stamm WE; Chromosomal restriction fragment length polymorphism analysis of Escherichia coli strains causing recurrent urinary tract infections in young women.; J Infect Dis; 1995 Aug; 172(2); 440-445 |
| Thomas Russo, Sharma G, Brown CR, Anthony Campagnari; Loss of the O4 antigen moiety from the lipopolysaccharide of an extraintestinal isolate of Escherichia coli has only minor effects on serum sensitivity and virulence in vivo.; Infect Immun; 1995 Apr; 63(4); 1263-1269 |
| Russo TA, Sharma G, Weiss J, Brown C; The construction and characterization of colanic acid deficient mutants in an extraintestinal isolate of Escherichia coli (O4/K54/H5).; Microb Pathog; 1995 Apr; 18(4); 269-278 |
| Russo TA, Liang Y, Cross AS; The presence of K54 capsular polysaccharide increases the pathogenicity of Escherichia coli in vivo.; J Infect Dis; 1994 Jan; 169(1); 112-118 |
| Russo TA, Singh G; An extraintestinal, pathogenic isolate of Escherichia coli (O4/K54/H5) can produce a group 1 capsule which is divergently regulated from its constitutively produced group 2, K54 capsular polysaccharide.; J Bacteriol; 1993 Dec; 175(23); 7617-7623 |
| Godoy VG, Dallas MM, Russo TA, Malamy MH; A role for Bacteroides fragilis neuraminidase in bacterial growth in two model systems.; Infect Immun; 1993 Oct; 61(10); 4415-4426 |
| Russo TA, Moffitt MC, Hammer CH, Frank MM; TnphoA-mediated disruption of K54 capsular polysaccharide genes in Escherichia coli confers serum sensitivity.; Infect Immun; 1993 Aug; 61(8); 3578-3582 |
| Russo TA, Guenther JE, Wenderoth S, Frank MM; Generation of isogenic K54 capsule-deficient Escherichia coli strains through TnphoA-mediated gene disruption.; Mol Microbiol; 1993 Jul; 9(2); 357-364 |
| Russo TA, Thompson JS, Godoy VG, Malamy MH; Cloning and expression of the Bacteroides fragilis TAL2480 neuraminidase gene, nanH, in Escherichia coli.; J Bacteriol; 1990 May; 172(5); 2594-2600 |
| Russo TA, Cook S, Gorbach SL; Intramuscular ceftriaxone in home parenteral therapy.; Antimicrob Agents Chemother; 1988 Sep; 32(9); 1439-1440 |
| Knight PR, Davidson BA, Nader ND, Helinski JD, Marschke CJ, Russo TA, Hutson AD, Notter RH, Holm BA; Progressive, severe lung injury secondary to the interaction of insults in
gastric aspiration.; Exp Lung Res; 30(7); 535-557 |
| Bianchine PJ, Russo TA; The role of epidemic infectious diseases in the discovery of America.; Allergy Proc; 13(5); 225-232 |
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