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Dr. William Ruyechan
Microbiology and Immunology
251 Biomedical Research Building
Buffalo NY, 14214
Phone: (716) 829-2312
Email: ruyechan@buffalo.edu
 View map |
DESCRIPTION OF INTERESTS
-My research interests center on protein-nucleic acid interactions in three different experimental systems: herpes simplex virus (HSV), varicella zoster virus (VZV) and the parasitic protozoan Trypanosoma brucei. The work with HSV involves functional analysis of the HSV major DNA-binding protein. We are presently mapping important regions of the protein by means of chemical modification, photo-crosslinking, and expression of fragments in prokaryotic vector systems. The regions being analyzed include the DNA-binding domain, a zinc binding site, and a region of the protein involved in cooperative binding. We have also recently generated site specific mutations at or near the residues believed to be involved in cooperative binding.
The work on VZV is focussed on VZV gene regulation and the molecular mechanisms required for the establishment and maintenance of VZV latency. Specifically we are attempting to determine the mechanism involved in the cell type specific up and down modulation of VZV transcriptional activity of the viral glycoprotein I promoter. This phenomenon appears to involve gene products which are present both during lytic and latent viral infection and may represent a unique role for the viral major DNA-binding protein.
Finally, in collaboration with Dr. Noreen Williams, a novel DNA polymerase and two RNA-binding proteins have been identified in T. brucei. The expression of the latter two proteins is developmentally regulated during the life cycle of the parasite. Work is currently underway to understand the functions of these polypeptides. The DNA polymerase represents a novel activity in the parasite mitochondrion and work on this enzyme will both provide insights into the molecular |
EDUCATION
| 1976 |
Ph.D., University of Illinois
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| 1974 |
Master of Science, Chemistry
University of Illinois
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| 1972 |
Bachelor of Science, Chemistry
Carnegie-Mellon University
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PUBLICATIONS
| Ruyechan W, Peng, H., Yang, M., Hay J; Cellular factors and IE62 activation of VZV promoters; J. Med. Virol.; 2003 Jan; |
| Ito, H., Sommer, M.H., Zerboni, L., He, H., Boucaud, D., Hay J, Ruyechan W, Arvin, A.M.; Promoter sequences of varicella-zoster virus glycoprotein 1 targeted by cellular transcription factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo; J. Virol.; 2003 Jan; 77; 489-498 |
| Arvin, A.M., Sharp, M., Moir, M., Kinchington, P.E., Sadeghi-Zadah, M., Ruyechan W, Hay J; Memory cytotoxic T cell responses to viral tegument and regulatory proteins encoded by open reading frames 4, 10, 29, and 62 of varicella zoster virus; Viral Immunology; 2002 Jan; 15; 507-516 |
| Lynch, J.M., Kenyon, T.K., Grose, C., Hay J, Ruyechan W; Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins; Virology; 2002 Jan; 302; 71-82 |
| Pitula, J., Park, J., Parsons, M., Ruyechan W, Williams N; Two families of RNA binding proteins from Trypanosoma brucei associate in a direct protein-protein interaction; Mol. Biochem. Parasit.; 2002 Jan; 122; 81-89 |
| Pitula J, Ruyechan WT, Williams N; Two Novel RNA Binding Proteins from Trypanosoma brucei Are Associated with 5S rRNA.; Biochem Biophys Res Commun; 2002 Jan; 290(1); 569-576 |
| Hellman, K., William Ruyechan, Noreen Williams; Characterization of the RNA binding properties and protein-protein interactions of p34 and p37 from Trypanosoma brucei; RNA Society Meeting, Banff, Alberta; 2001 Jan; |
| He, H., Boucaud, D., Hay J, Ruyechan W; Cis and trans elements regulating expression of the varicella zoster virus gl gene; Arch. Virol.; 2001 Jan; 17; S57-S70 |
| Dudas, K.C., Scouten, S., Ruyechan W; Conformational change in the herpes simplex single-strand binding protein induced by DNA; Biochem. Biophys. Res. Comm.; 2001 Jan; 288; 184-190 |
| Li, J., William Ruyechan, Noreen Williams; Differential regulation of two homologous nucleic acid binding proteins in T. brucei, p34 and p37; 2nd Internatioinal Conference on proteins that Bind RNA, Austin/Lake Travis, Texas; 2001 Jan; |
| Li, J., William Ruyechan, Noreen Williams; Differential regulation of two homologous RNA binding proteins in T. brucei, p34 and p37; RNA Society Meeting, Banff, Alberta; 2001 Jan; |
| Spengler, M., Ruyechan W, Hay J; Interactions among structural proteins of varicella zoster virus; Arch. Virol.; 2001 Jan; 17; S71-S79 |
| Sommer, M.H., Zagha, E., Serrano, O.K., Ku, C.C., Zerboni, L., Baiker, A., Santos, R., Spengler, M., Lynch, J., Grose, C., Ruyechan W, Hay J, Arvin, A.M.; Mutational analysis of the repeated open reading frames ORFs 63 and 70 and ORFs 64 and 69 of varicella zoster virus; J. Virol.; 2001 Jan; 75; 8224-8239 |
| Santos, R.A., Hatfield, C.C., Faga, B.P., Padilla, J.A., Cole, N.L., Moffat, J.F., Arvin, A.M., Spengler, M., Ruyechan W, Hay J, Grose, C.; Varicella zoster virus gE escape mutant VZV-MSP exhibits a novel genotype with an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice; Virology; 2001 Jan; 75; 8224-8239 |
| Kenyon, T.K., Lynch, J., Hay J, Ruyechan W, Grose, C.; Varicella-zoster virus ORF47 protein kinase: characterization of a cloned, biologically active phosphotransferase and its viral substrates the ORF62 and ORF63 proteins; J. Virol.; 2001 Jan; 75; 8854-8858 |
| William Ruyechan, John Hay; VZV DNA replication; Varicella Zoster Virus; 2001 Jan; |
| Santos RA, Hatfield CC, Cole NL, Padilla JA, Moffat JF, Arvin AM, William Ruyechan, Hay J, Grose C; Varicella-zoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice.; Virology; 2000 Sep; 275(2); 306-317 |
| Spengler ML, William Ruyechan, Hay J; Physical interaction between two varicella zoster virus gene regulatory proteins, IE4 and IE62.; Virology; 2000 Jul; 272(2); 375-381 |
| Li, J., William Ruyechan, Noreen Williams; Differential regulation of two homologous RNA binding proteins in Trypanosoma brucei, p34 and p37; RNA Society Meeting, Madison, Wisconsin; 2000 Jan; |
| Spengler, M.L., Ruyechan W, Hay, J.; Physical interaction between two varicella zoster gene regulatory proteins, IE4 and IE62; Virology; 2000 Jan; 272; 375-381 |
| Pitula, J., William Ruyechan, Noreen Williams; Two families of RNA binding proteins from Trypanosoma brucei associate in a complex which contains 5S rRNA; RNA Society Meeting, Madison Wisconsin; 2000 Jan; |
| Ruyechan W, Hay J; Varicella Zoster Virus: DNA Replication; Varicella Zoster virus: virology and clinical management; 2000 Jan; |
| Pitula, J., William Ruyechan, Noreen Williams; Two novel RNA binding proteins from Trypanosoma brucei; RNA Society Meeting, Edinburgh, Scotland; 1999 Jan; |
| William Ruyechan, John Hay; Varicella zoster virus: molecular biology; Encyclopedia of Virology; 1999 Jan; |
| Boucaud D, Yoshitake H, Hay J, William Ruyechan; The varicella-zoster virus (VZV) open-reading frame 29 protein acts as a modulator of a late VZV gene promoter.; J Infect Dis; 1998 Nov; 178 S; 34-38 |
| Zhang J, William Ruyechan, Williams N; Developmental regulation of two nuclear RNA binding proteins, p34 and p37, from Trypanosoma brucei.; Mol Biochem Parasitol; 1998 Apr; 92(1); 79-88 |
| Pitula J, William Ruyechan, Williams N; Trypanosoma brucei: identification and purification of a poly(A)-binding protein.; Exp Parasitol; 1998 Feb; 88(2); 157-160 |
| Zhang, J., Ruyechan W, Williams, N.; Developmental regulation of two nuclear RNA binding proteins, p34 and p37, from Trypanosoma brucei; Mol. Biochem, Parasit.; 1998 Jan; 92; 79-88 |
| Zhang, J., William Ruyechan, Noreen Williams; Developmental regulation of two nuclear RNA binding proteins, p34 and p37, from Trypanosoma brucei; Mol. Biochem. Parasitol.; 1998 Jan; 92; 29-38 |
| Fuenmayor, J., Zhang, J., William Ruyechan, Noreen Williams; Identification and characterization of two DNA polymerase activities present in Trypanosoma brucei mitochondria; J. Euk. Microbiol.; 1998 Jan; 45; 404-410 |
| Dudas KC, William Ruyechan; Identification of a region of the herpes simplex virus single-stranded DNA-binding protein involved in cooperative binding.; J Virol; 1998 Jan; 72(1); 257-265 |
| Dudas, K.C., Ruyechan W; Identification of a region of the herpes simplex virus SSB involved in cooperative binding; J. Virol.; 1998 Jan; 72; 257-265 |
| Pitula, J., William Ruyechan, Noreen Williams; T. brucei: identification and purification of a poly A binding protein; Exp. Parasitol.; 1998 Jan; 88; 157-160 |
| Boucaud, D., Yoshitake, H., Hay, J., Ruyechan W; The VZV ORF 29 protein acts as a modulator of a late VZV gene promoter; Journal of Infectious Diseases; 1998 Jan; 178(1); 34-38 |
| Pitula, J., Ruyechan W, Williams, N.; Trypanosoma brucei: Identification and purification of a poly A binding protein; Exptl. Parasit.; 1998 Jan; 88; 157-160 |
| Zhang, J., William Ruyechan, Noreen Williams; Characterization of Trypanosoma brucei Single-Strand Nucleic Acid Binding Proteins p34 and p37; Global Meeting on Parasitic Disease, New Delhi, India; 1996 Jan; |
| Stevenson, D., Xue, M., Hay, J., Ruyechan W; Phosphorylation and nuclear localization of the varicella zoster virus gene 63 protein; J. Virol.; 1996 Jan; 69; 658-662 |
| Stevenson D, Xue M, Hay J, William Ruyechan; Phosphorylation and nuclear localization of the varicella-zoster virus gene 63 protein.; J Virol; 1996 Jan; 70(1); 658-662 |
| Kantakamalakul W, William Ruyechan, Hay J; Analysis of varicella-zoster virus promoter sequences.; Neurology; 1995 Dec; 45(12 Su); 28-29 |
| Kantakamalakul, W., Ruyechan W, Hay, J.; Analysis of varicella-zoster virus promoter sequences; Neurology; 1995 Jan; 45(8); 28-29 |
| Shelton LS, Albright AG, William Ruyechan, Jenkins FJ; Retention of the herpes simplex virus type 1 (HSV-1) UL37 protein on single-stranded DNA columns requires the HSV-1 ICP8 protein.; J Virol; 1994 Jan; 68(1); 521-525 |
| Shelton, L.G., Allbright, A.G., Ruyechan W, Jenkins, F.J.; Retention of the HSV-1 UL37 protein on single-stranded DNA columns requires the HSV-1 ICP8 protein; J. Virol.; 1994 Jan; 68(1); 521-525 |
| John Hay, William Ruyechan; Varicella zoster virus; Seminars in Virology; 1994 Jan; 5; 241-247 |
| Hay J, Ruyechan W; Varicella zoster virus - a different kind of herpesvirus latency?; Seminars in Virology; 1994 Jan; 5; 241-247 |
| John Hay, William Ruyechan; Varicella zoster virus-a different kind of herpesvirus latency?; Virology; 1994 Jan; 5; 241-247 |
| Ruyechan W, Hay J; Varicella zoster virus: Molecular Biology; Encyclopedia of Virology; 1994 Jan; 2; 1518-1527 |
| William Ruyechan, John Hay; Varicella zoster; molecular biology; Encyclopedia of Virology; 1994 Jan; 2; 1518-1527 |
| Sabella C, Lowry PW, Abbruzzi GM, Koropchak CM, Kinchington PR, Sadegh-Zadeh M, Hay J, William Ruyechan, Arvin AM; Immunization with the immediate-early tegument protein (open reading frame 62) of varicella-zoster virus protects guinea pigs against virus challenge.; J Virol; 1993 Dec; 67(12); 7673-7676 |
| Perera LP, Mosca JD, William Ruyechan, Hayward GS, Straus SE, Hay J; A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain.; J Virol; 1993 Aug; 67(8); 4474-4483 |
| Perera, L., Mosca, J.D., Ruyechan W, Hayward, G.A., Straus, S.E., Hay, J.; A major transactivator of varicella zoster virus, the immediate early protein, IE 62, contains a potent N-terminal activation domain; J. Virol.; 1993 Jan; 67; 4474-4483 |
| William Ruyechan, Noreen Williams; DNA binding Proteins of Trypanosoma brucei; International Congress of Protozoology, Berlin, Ge rmany; 1993 Jan; |
| Sabella, C., Lowry, P.W., Abruzi, G.M., Koropchak, C.W., Kinchington, P.R., Sadeghi-Zadah, M., Hay, J., Ruyechan W, Arvin, A.M.; Immunization with the immediate early tegument protein (open reading frame 62) of varicella-zoster virus protects guinae pigs against virus challenge; J. Virol.; 1993 Jan; 67; 7673-7676 |
| William Ruyechan, Olson JW; Surface lysine and tyrosine residues are required for interaction of the major herpes simplex virus type 1 DNA-binding protein with single-stranded DNA.; J Virol; 1992 Nov; 66(11); 6273-6279 |
| Perera LP, Mosca JD, Sadeghi-Zadeh M, William Ruyechan, Hay J; The varicella-zoster virus immediate early protein, IE62, can positively regulate its cognate promoter.; Virology; 1992 Nov; 191(1); 346-354 |
| Perera LP, Mosca JD, William Ruyechan, Hay J; Regulation of varicella-zoster virus gene expression in human T lymphocytes.; J Virol; 1992 Sep; 66(9); 5298-5304 |
| Ling P, Kinchington PR, Sadeghi-Zadeh M, William Ruyechan, Hay J; Transcription from varicella-zoster virus gene 67 (glycoprotein IV).; J Virol; 1992 Jun; 66(6); 3690-3698 |
| Sharp M, Terada K, Wilson A, Nader S, Kinchington PE, William Ruyechan, Hay J, Arvin AM; Kinetics and viral protein specificity of the cytotoxic T lymphocyte response in healthy adults immunized with live attenuated varicella vaccine.; J Infect Dis; 1992 May; 165(5); 852-858 |
| Lowry PW, Solem S, Watson BN, Koropchak CM, Thackray HM, Kinchington PR, William Ruyechan, Ling P, Hay J, Arvin AM; Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62.; J Gen Virol; 1992 Apr; 73 (; 811-819 |
| John Hay, William Ruyechan; Expression and function of herpes simplex virus gene products; The Immunobiology of Herpes Simplex Infections; 1992 Jan; |
| Lowry, P.W., Solem, S., Watson, B.N., Koropchak, C.M., Thackery, H.M., Kinchington, P.R., Ruyechan W, Ling, P., Hay, J., Arvin, A.M.; Immunity in strain 2 guinae pigs inoculated with vaccinia recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the immediate early Gene 62; J. Gen. Virol.; 1992 Jan; 73; 811-819 |
| John Hay, William Ruyechan; Regulation of herpes simplex virus Type 1 gene expression; Current Topics in Microbiol. and Immunol.; 1992 Jan; 179; 1-14 |
| Ruyechan W, Hay J; Regulation of herpes simplex virus type 1 gene expression; The Immunobiology of Herpes Simplex Infections; 1992 Jan; |
| Ruyechan W, Olson, J.W.; Surface lysine and tyrosine residues are required for the interaction of the major herpes simplex virus type 1 DNA-binding prtein with single-stranded DNA; J. Virol.; 1992 Jan; 66; 6273-6279 |
| Sharp, M., Terada, K., Wilson, A., Nader, S., Kinchington, P.R., Ruyechan W, Hay, J., Arvin, A.M.; The kinetics and viral protein specificity of the cytotoxic T-lymphocyte response in healthy adults immunized with live attenuated varicella vaccine; J. Int. Dis.; 1992 Jan; 165; 852-858 |
| Gray, W.L., Pumphrey, C.Y., Ruyechan W, Fletcher, T.M.; The simian varicella virus and varicella zoster virus genomes are similar in size and structure; Virology; 1992 Jan; 186; 562-572 |
| Perera, L., Mosca, J.D., Ruyechan W, Hay, J.; The varicella Zoster virus immediate early prrotein IE 62, can positively regulate its cognate promoter; Virology; 1992 Jan; 191; 346-354 |
| Kinchington PR, Hougland JK, Arvin AM, Ruyechan WT, Hay J; The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles.; J Virol; 1992 Jan; 66(1); 359-366 |
| Ling, P., Kinchington, P.R., Ruyechan W, Hay, J.; Transcription from varicella-zoster virus gene 67 (glycoprotein IV); J. Virol.; 1992 Jan; 66; 3690-3698 |
| Ling P, Kinchington PR, Ruyechan WT, Hay J; A detailed analysis of transcripts mapping to varicella zoster virus gene 14 (glycoprotein V).; Virology; 1991 Oct; 184(2); 625-635 |
| Arvin AM, Sharp M, Smith S, Koropchak CM, Diaz PS, Kinchington P, Ruyechan W, Hay J; Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype.; J Immunol; 1991 Jan; 146(1); 257-264 |
| Kinchington, P.R., William Ruyechan, John Hay; Herpesvirus vaccines; Vaccines and Immunotherapy; 1991 Jan; |
| Kinchington, P.R., Ruyechan W, Hay J; Herpesvirus vaccines; Vaccines and Immunotherapy, The Swiss Vaccine Institute; 1991 Jan; |
| Ruyechan W, Ling, P., Kinchington, P.R., Hay J; The correlation between varicella-zoster virus transcription and the sequence of the viral genome; Herpesvirus Transcription and Its Regulation; 1991 Jan; |
| Gupte, S.S., Olson, J., Ruyechan W; The major herpes simplex virus type-1 DNA binding protein is a zinc metalloprotein; J. Biol. Chem.; 1991 Jan; 266; 11413-11416 |
| Williams, N., Choi, S.Y.W., Ruyechan W, Frank, P.T.; The mitochondrial ATP synthase of Trypanosoma brucei: Developmental regulation through the life cycle; Arch. Bioch. and Biophys.; 1991 Jan; 288; 509-515 |
| Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., Hay J, Ruyechan W; A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus; Adv. Exptl. Med. Biol.; 1990 Jan; 278; 83-91 |
| Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., John Hay, William Ruyechan; A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus; Advances in Exp. Med. Biol.; 1990 Jan; 278; 83-91 |
| Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., John Hay, William Ruyechan; A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus; Immunobiology and Prophylaxis of Human Herpesvirus Infections; 1990 Jan; |
| Feuerstein, N., Mond, J., Kinchington, P.R., Hickey, R., Lindsbert, M.-L., John Hay, William Ruyechan; Evidence for DNA binding activity of numatrin (B23), a cell cycle-regulated nuclear matrix protein; Biochem. Biophys. Acta.; 1990 Jan; 1087; 127-136 |
| William Ruyechan, Ling, P., Kinchington, P.R., John Hay; The correlation between varicella zoster virus transcription and the sequence of the viral genome; Herpesvirus Transcription and Its Regulation; 1990 Jan; |
| Kinchington, P.R., Ling, P., Pensiero, M., Moss, B., William Ruyechan, John Hay; The glycoprotein products of varicella-zoster virus gene 14 and their defective accumulation in a vaccine strain (Oka); J. Virol.; 1990 Jan; 64; 4540-4548 |
| Haffey, M.L., Stevens, J.T., Terry, B.J., Dorsky, D.I., Crumpacker, C.S., Wietstock, S.M., Ruyechan W, Field, A.K.; Expression of herpes simplex type-1 DNA polymerase in Saccharomyces cerevisiae and detection of viral specific enzyme activity in cell free lysates; J. Virol.; 1988 Jan; 62; 4493-4498 |
| Holmes, A.M., Wietstock, S.M., Ruyechan W; Identification and characterization of a DNA primase activity present in herpes simplex virus type-1 infected cells; J. Virol.; 1988 Jan; 62; 1038-1045 |
| Kinchington, P.R., Inchuaspe, G., Subak-Sharpe, J.H., Robey, F., John Hay, William Ruyechan; Identification and characterization of a varicella-zoster virus DNA-binding protein by using antiseera directed against a predicted synthetic oligopeptide; J. Virol.; 1988 Jan; 62; 802-809 |
| Ruyechan W; N-ethylymaleimide inhibition of the DNA-binding activity of the herpes simplex virus type 1 major DNA-binding protein; J. Virol.; 1988 Jan; 62; 810-817 |
| John Hay, Roberts, C.R., William Ruyechan, Steven, A.C.; Herpesviridae; Animal Virus Structure; 1987 Jan; |
| Holmes, R. K., Green, B.A., Twiddy, E.M., Neil, R.J., Ruyechan W; Genetic and biochemical studies of a new heat-labile enterotoxin of Escherichia coli that activates adenylate cyclase; Advances in Research on Cholera and Related Diarrheas 3, S.; 1986 Jan; |
| Ruyechan W, Weir, A.C., Fisher, C.M.; In vitro characterization of a thermolabile herpes simplex virus DNA-binding protein; J. Virol.; 1986 Jan; 50; 31-36 |
| Rota, P.A., Maes, R.K., Ruyechan W; Physical characterization of the genome of feline herpes-virus-1; Virology; 1986 Jan; 154; 168-179 |
| Kinchington, P.R., Remenick, J., Ostrove, J.M., Straus, S.E., William Ruyechan, John Hay; Putative glycoprotein gene of varicella-zoster virus with variable copy numbers of a 42-base- pair repeat sequence has homology to herpes simplex virus glycoprotein C.; J. Virol.; 1986 Jan; 59; 660-669 |
| William Ruyechan, Casey, T.A., Reinhold, W., Weir, A.C., Wellman, M., Straus, S.E., John Hay; Distribution of G+C-rich regions in varicella-zoster virus DNA; J. Gen. Virol.; 1985 Jan; 66; 43-54 |
| Roberts, C.R., Weir, A.C., John Hay, Straus, S.E., William Ruyechan; DNA-binding proteins present in varicella-zoster virus-infected cells; J. Virol.; 1985 Jan; 55; 45-53 |
| Casey, T.A., William Ruyechan, Flora, M.N., Reinhold, W., Straus, S.E., John Hay; Fine mapping and sequencing of a variable setment in the inverted repeat region of varicella zoster virus DNA; J. Virol.; 1985 Jan; 54; 639-642 |
| Kinchington, P.R., Reinhold, W.C., Casey, T.A., Straus, S.E., John Hay, William Ruyechan; inversion and circularization of the varicella zoster virus genome; J. Virol.; 1985 Jan; 56; 194-200 |
| Ruyechan W, Casey, T.A., Reinhold, W., Weir, A.C., Wellman, M., Straus, S.E., Hay J; Distribution of G+C-rich regions in varicella zoster virus DNA; J. Gen. Virol.; 1984 Jan; 66; 43-54 |
| Straus, S.E., Reinhold, W., Smith, H.A., William Ruyechan, Henderson, D.K., Blaese, R.M., John Hay; Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient; N. Engl. J. Med.; 1984 Jan; 311; 1362-1364 |
| Ruyechan W, Weir, A.C.; Interaction with nucleic acids and stimulation of the viral DNA polymerase by the herpes simplex virus type 1 major DNA binding protein; J. Virol.; 1984 Jan; 52; 727-733 |
| Green, B.A., Neill, R.J., Ruyechan W, Holmes, R.K.; Evidence that a new enterotoxin of Escherichia coli which activates adenylate cyclase in eucaryotic target cells is not plasmid mediated; Infec. Immun.; 1983 Jan; 41; 383-390 |
| Badarraco, G., Plevani, P., Ruyechan W, Chang, L.M.S.; Purification and characterization of yeast topoisomerase 1; J. Biol. Chem.; 1983 Jan; 46; 2022-2026 |
| Ruyechan W; The major herpes simplex virus DNA binding protein holds single-stranded DNA in an extended configuration; J. Virol.; 1983 Jan; 46; 661-666 |
| Ruyechan W, Dauenhauer, S.A., O'Callaghan, D.J.; Electron microscopic study of equine herpesvirus type 1 DNA; J. Virol.; 1982 Jan; 42; 297-300 |
| Straus, S.E., Owens, J., William Ruyechan, Takiff, H., Casey, T.A., Vande Woude, G.F., John Hay; Molecular cloning and physical mapping of varicella zoster virus DNA; Proc. Nat. Acad. Sci. (Wash); 1982 Jan; 79; 993-997 |
| Atherton, S.S., Sullivan, D.C., Dauenhauer, S.A., Ruyechan W, O'Callaghan, D.J.; Properties of the genome of equine herpesvirus type 3; Virology; 1982 Jan; 120; 18-32 |
| Wetmur, J.G., Ruyechan W, Douthart, R.J.; Denaturation and renaturation of Penicillium chrysogenum macrophage double-stranded RNA in tetra-alkyl ammonium salt solutions; Biochemistry; 1981 Jan; 20; 2999-3002 |
| Straus, S.E., Aulakh, H.S., William Ruyechan, John Hay, Casey, T.A., Vande Woude, G.F., Owens, J., Smith, H.A.; Structure of varicella zoster virus DNA; J. Virol.; 1981 Jan; 40; 516-525 |
| Ruyechan W, Morse, L.S., Knipe, D.M., Roizman, B.; Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells; J. Virol.; 1979 Jan; 29; 667-697 |
| Knipe, D.M., Ruyechan W, Roizman, B.; Molecular genetics of herpes simplex virus. III. Fine mapping of a genetic locus determining resistance to phosphonoacetate by two methods of marker transfer; J. Virol.; 1979 Jan; 29; 698-704 |
| Knipe, D.M., Ruyechan W, Honess, R.W., Roizman, B.; Molecular genetics of herpes simplex virus: The terminal a sequences of the L and S components are obligatorially identical and constitute a part of a structural gene mapping predominantly in the S component; Proc. Nat. Acad. Sci.; 1979 Jan; 76; 4534-4538 |
| Roizman, B., Jacob, R.J., Knipe, D., Morse, L.S., Ruyechan W; On the structure, functional equivalence and replication of the four arrangements of herpes simplex virus DNA; Cold Spring Harbor Symp. Quan. Biol.; 1979 Jan; 43; 808-826 |
| Knipe, D.M., Ruyechan W, Roizman, B., Halliburton, I.W.; Molecular genetics of herpes simplex virus: Demonstration of regions of obligatory and non-obligatory identity within diploid regions of the genome; Proc. Nat. Acad. Sci.; 1978 Jan; 75; 3896-3900 |
| Chan, H.-C., Ruyechan W, Wetmur, J.G.; In vitro iodination of low complexity nucleic acids without chain scission; Biochemistry; 1976 Jan; 15; 5487-5490 |
| Ruyechan W, Wetmur, J.G.; Studies on the non-cooperative binding of the Escherichia coli DNA unwinding protein to single stranded nucleic acids; Biochemistry; 1976 Jan; 15; 5057-5064 |
| Ruyechan W, Wetmur, J.G.; Studies on the cooperative binding of the Escherichia coli DNA unwinding protein to single-stranded DNA; Biochemistry; 1975 Jan; 14; 5529-5534 |
| He H, Boucaud D, John Hay, William Ruyechan; Cis and trans elements regulating expression of the varicella zoster virus gI gene.; Arch Virol Suppl; (17); 57-70 |
| Fuenmayor J, Zhang J, William Ruyechan, Williams N; Identification and characterization of two DNA polymerase activities present in Trypanosoma brucei mitochondria.; J Eukaryot Microbiol; 45(4); 404-410 |
| Spengler M, Niesen N, Grose C, William Ruyechan, John Hay; Interactions among structural proteins of varicella zoster virus.; Arch Virol Suppl; (17); 71-79 |
GRANTS
September 2002 to August 2007
Tegument Proteins Involved in VZV Pathogenesis
NIH
Arvin, A., William Ruyechan
$1,250,000
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July 2001 to June 2004
Single-stranded Binding Proteins in Trypanosoma cruzi
NIH/Fogarty FIRCA
Noreen Williams
$118,108
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July 2001 to June 2002
UB Graduate Group Award
Buffalo DNA Replication Graduate Group
Thomas Melendy, William Ruyechan, Noreen Williams
$3,000
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April 1999 to March 2004
Developmental Regulation of DNA/RNA Binding Proteins
NIH
Noreen Williams
$885,006
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June 1997 to May 2003
Structure and Function of Varicella Zoster Virus DNA
NIH
William Ruyechan
$977,162
|
May 1995 to April 1996
Characterization of a Novel DNA Polymerase from Trypanosoma brucei
UB Multidisciplinary Pilot Project Program
Noreen Williams, William Ruyechan
$20,000
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September 1990 to August 1996
Structure and Function of Varicella-Zoster Virus DNA
NIH
William Ruyechan
$623,208
|
September 1985 to March 1994
Proteins Involved in Replication and Expression of HSV DNA
NIH
William Ruyechan
$446,873
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August 1982 to August 1990
Structure of Varicella Zoster Virus DNA
NIH
William Ruyechan
$503,700
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