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OFFICE LOCATIONS
Roswell Park Cancer Institute
Elm & Carlton Streets
Buffalo NY, 14263
Phone: 716-845-3360
Fax: 716-845-3423
Contact: Milly
Email: bhsegal@buffalo.edu
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DESCRIPTION OF INTERESTS
Fungal Infections in Cancer Patients
Neutrophil Defects
Aspergillus infections
Vaccine development
My lab is focused on two different but related areas of research. We are studying the role of reactive oxidants generated by the phagocyte NADPH oxidase on host defense and inflammation by using a mouse knockout model of chronic granulomatous disease (CGD). CGD results from a defect in the NADPH oxidase rendering patients susceptible to recurrent bacterial and fungal pathogens as well as abnormally exuberant inflammatory responses, which may manifest as granulomatous enteritis and obstruction of the genitourinary tract.
The other major focus of my lab is related Aspergillus infection. We are studying the immunology of Aspergillus infection in patients and animal models with the aim of developing novel immune augmentation strategies. In addition, we have established collaboration with our colleagues in pharmacology to develop and evaluate combination antifungal regimens against Aspergillus infection.
In addition to basic science, we have an active clinical research program focused on trials involving treatment and prevention of infections in immunocompromised patients with cancer. Most of the clinical research focuses on opportunistic fungal infections.
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SPECIALTIES
EDUCATION
| 1999 |
Fellowship, Infectious Diseases
National Institute of Allergy and Infectious Diseases
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| 1995 |
Residency, Medicine
Tufts New England Medical Center
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| 1992 |
M.D., Albert Einstein College of Medicine
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PUBLICATIONS
| Almyroudis N, Segal BH; Antibacterial prophylaxis in patients with cancer and neutropenia.; New England Journal of Medicine; 2006 Jan; 354(1); 90-94 |
| Almyroudis N, Holland SM, Segal BH; Invasive aspergillosis in primary immunodeficiencies.; Med Mycol.; 2005 May; 43(1); S247-S259 |
| Smiley S, Almyroudis N, Segal BH; Epidemiology and management of opportunistic infections in immunocompromised patients with cancer.; Hematology & Oncology; 2005; 8(3); 20-30 |
| SEGAL BH; Phagocyte NADPH oxidase is essenital in control of Burkholderia cepacia and Chromobacterium violaceum in mice.; Infection and Immunity; 2003; 71; 205-210 |
| SEGAL BH; Fungal infections in patients with hematologic malignancies.; Infectious Diseases Clinics of North America; 2002; 16; 935-964 |
| SEGAL BH; Leukotrienes, the NADPH oxidase, and complement are critical regulators of thioglycollate peritonitis in mice.; Journal of Leukocyte Biology; 2002; 71; 410-416 |
| SEGAL BH; Impaired pulmonary NF-kB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice.; Infection and Immunity; 2001; 69; 5991-5996 |
| SEGAL BH; Infections in the cancer patient.; Cancer: Principles and Practice of Oncology; 2001; |
| SEGAL BH; NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.; Journal of Clinical Investigation; 2000; 106; 867-872 |
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