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Dr. Richard Bankert
Microbiology and Immunology
Professor of Microbiology; Professor of Microbiology
217 Biomedical Research Building
Buffalo NY, 14214
Phone: (716) 829-2701
Email: rbankert@buffalo.edu
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DESCRIPTION OF INTERESTS
-Research focuses on immunity and immunotherapy of human cancer. To study the immune response of patients to their tumors and to evaluate ways to enhance this immunity (by tumor vaccination or cytokines delivered by gene therapy or biode-gradable microspheres), mouse models have been developed in which we can engraft patient tumors and their immunocompetent cells. Students and postdoctoral fellows in this laboratory were the first to show that human tumors grow and metastasize when inoculated into the severe combined immunodeficient (SCID) mice.
Subsequently, our research team showed that non-disrupted pieces of tumor biopsy tissues implanted into SCID mice caused co-engraftment of patient tumors and their tumor infiltrating lymphocytes (TIL). The tumor/TIL SCID model was used to establish that TIL within the tumor graft remain functional and respond to lymphocyte growth factors (cytokines). This model is being exploited to evaluate three methods of cytokine delivery to tumors: bolus injections, biodegradable microspheres and gene therapy.
We have determined that peripheral blood lymphocytes of patients remain functional when injected subcutaneously into SCID mice with tumor cells. These cells mount an immune response that can be monitored and studied for up to 22 weeks. This model (termed SCID/WINN assay) was used to demonstrate that T cell and NK cell dependent antitumor responses are enhanced with cytokines. Ways to augment this tumor immunity by enhancing lymphocyte co-stimulatory molecules or by blocking negative signals, i.e., through CTLA-4, are being explored
SCID models and in vitro immu-noassays are being used to evaluate several dendritic cell-based vaccination strategies for lung cancer and B-cell lymphomas. Tumor-specific antigens defined on human and mouse B-cell lymphomas are being identified (i.e., VH region peptides) and studied for their ability to provoke protective antitumor immunity. Some of these strategies are being tested in Phase I clinical trials at Roswell Park.
In addition to preclinical studies, this laboratory is involved with basic science issues involving the immune response to well-defined antigens. Interests include: (a) defining the role of cell adhesion molecules (particularly b1 integrins) in the induction and regulation of cognitive immune responses, and (b) exploring the mechanisms by which B-cell clones are selected and regulated during an immune response. |
EDUCATION
| 1973 |
Ph.D., Immunology
University of Pennsylvania
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| 1968 |
V.M.D., Vet. Medicine
University of Pennsylvania
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| 1962 |
Bachelor of Arts, Chem. & Biol.
Gettysburg College
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PUBLICATIONS
| Simpson-Abelson MR, Sonnenberg GF, Takita H, Yokota SJ, Conway TF, Kelleher RJ, Shultz LD, Barcos M, Bankert RB; Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.; J Immunol; 2008 May; 180(10); 7009-7018 |
| Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB; Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.; J Immunol; 2007 May; 178(9); 5552-5562 |
| Lou Q, Conway TF, Egilmez NK, Loyall JL, Bernstein SH, Kelleher RJ, Bankert RB; B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface
proteins on dendritic cells.; Clin Immunol; 2006 Jan; 118(1); 66-76 |
| Sabel MS, Hess SD, Egilmez NK, Conway TF, Chen FA, Bankert RB; CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor
xenografts in SCID mice.; Cancer Immunol Immunother; 2005 Oct; 54(10); 944-952 |
| Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB; Human CD4+ effector memory T cells persisting in the microenvironment of lung
cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate
tumor cells.; J Immunol; 2005 Jan; 174(2); 898-906 |
| Lou Q, Kelleher RJ, Sette A, Loyall J, Southwood S, Bankert RB, Bernstein SH; Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific
immune response without altering the response potential of normal B cells.; Blood; 2004 Aug; 104(3); 752-759 |
| Anderson TM, Hess SD, Egilmez NK, Nwogu CE, Lenox JM, Bankert RB; Comparison of human lung cancer/SCID mouse tumor xenografts and cell culture
growth with patient clinical outcomes.; J Cancer Res Clin Oncol; 2003 Oct; 129(10); 565-568 |
| Hess SD, Egilmez NK, Bailey N, Anderson TM, Mathiowitz E, Bernstein SH, Bankert RB; Human CD4+ T cells present within the microenvironment of human lung tumors
are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects
of IFN-gamma.; J Immunol; 2003 Jan; 170(1); 400-412 |
| Hess, S.D., Egilmez, N.K., Bailey, N., Anderson, T.M., Mathiowitz, E., Bernstein, S.H., Bankert R; Human CD4+ T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors In Situ by indirect effects of IFN-gamma; J. Immunol.; 2003 Jan; 170; 400-412 |
| Hess SD, Egilmez NK, Bailey N, Anderson TM, Mathiowitz E, Bernstein SH, Bankert RB; Human CD4+ T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma.; J Immunol; 2003 Jan; 170(1); 400-412 |
| Hill HC, Conway TF, Sabel MS, Jong YS, Mathiowitz E, Bankert RB, Egilmez NK; Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating
factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated
disease.; Cancer Res; 2002 Dec; 62(24); 7254-7263 |
| Egilmez NK, Hess SD, Chen FA, Takita H, Conway TF, Bankert RB; Human CD4+ effector T cells mediate indirect interleukin-12- and interferon-gamma-dependent
suppression of autologous HLA-negative lung tumor xenografts in severe combined immunodeficient mice.; Cancer Res; 2002 May; 62(9); 2611-2617 |
| Bankert RB, Hess SD, Egilmez NK; SCID mouse models to study human cancer pathogenesis and approaches to therapy:
potential, limitations, and future directions.; Front Biosci; 2002 Apr; 7; 44-62 |
| Egilmez, N.K., Hess, S.D., Chen, F-A., Takita, H., Conway, T., Richard Bankert; Human CD4+ Effector T-Cells Mediate an Indirect IL-12 and IFN-gamma-Dependent Suppression of Autologous Lung Tumor Xenografts in SCID Mice; Cancer Res.; 2002 Jan; |
| Sabel MS, Hill H, Jong YS, Mathiowitz E, Bankert RB, Egilmez NK; Neoadjuvant therapy with interleukin-12-loaded polylactic acid microspheres
reduces local recurrence and distant metastases.; Surgery; 2001 Sep; 130(3); 470-478 |
| Sabel MS, Hill H, Jong YS, Mathiowitz E, Bankert RB, Egilmez NK; Neoadjuvant therapy with interleukin-12-loaded polylactic acid microspheres reduces local recurrence and distant metastases.; Surgery; 2001 Sep; 130(3); 470-478 |
| Bankert RB, Egilmez NK, Hess SD; Human-SCID mouse chimeric models for the evaluation of anti-cancer therapies.; Trends Immunol; 2001 Jul; 22(7); 386-393 |
| Sugano M, Conway TF, Kelleher RJ, Sugiyama Y, Chen FA, Bankert RB, Bernstein SH; Human dendritic cells pulsed with autologous Epstein-Barr virus transformed
B-cell lymphoblastoid cell (BCL) lysate elicit a BCL specific MHC-class II restricted T-cell response.; J Exp Clin Cancer Res; 2001 Jun; 20(2); 175-182 |
| Sugano M, Conway TF, Kelleher RJ, Sugiyama Y, Chen FA, Bankert RB, Bernstein SH; Human dendritic cells pulsed with autologous Epstein-Barr virus transformed B-cell lymphoblastoid cell (BCL) lysate elicit a BCL specific MHC-class II restricted T-cell response.; J Exp Clin Cancer Res; 2001 Jun; 20(2); 175-182 |
| Hess SD, Egilmez NK, Shiroko J, Bankert RB; Antitumor efficacy of a human interleukin-12 expression plasmid demonstrated
in a human peripheral blood leukocyte/human lung tumor xenograft SCID mouse model.; Cancer Gene Ther; 2001 May; 8(5); 371-377 |
| Hess SD, Egilmez NK, Shiroko J, Bankert RB; Antitumor efficacy of a human interleukin-12 expression plasmid demonstrated in a human peripheral blood leukocyte/human lung tumor xenograft SCID mouse model.; Cancer Gene Ther; 2001 May; 8(5); 371-377 |
| Yamada M, Shiroko T, Kawaguchi Y, Sugiyama Y, Egilmez NK, Chen FA, Bankert RB; CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating
MHC class I, ICAM-1 and Fas expression and proliferation of human non-small cell lung tumors.; Int J Cancer; 2001 May; 92(4); 589-599 |
| Yamada M, Shiroko T, Kawaguchi Y, Sugiyama Y, Egilmez NK, Chen FA, Bankert RB; CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM-1 and Fas expression and proliferation of human non-small cell lung tumors.; Int J Cancer; 2001 May; 92(4); 589-599 |
| Sugiyama, Y., Kato, M., Chen, F-A., Williams, S.S., Kawaguchi, Y., Miya, K., Jong, Y.S., Mathiowitz,E., Egilmez, N.K., Richard Bankert; Human inflammatory cells within the tumor microenvironment of lung tumor xenografts mediate tumor growth suppression in situ that depends on and is augmented by interleukin-12; J. Immunotherapy; 2001 Jan; 24; 37-45 |
| Bankert RB, Egilmez NK, Hess, S.D.; Human/SCID Chimeric Models for Pre-clinical Evaluation of Anti-Cancer Therapies: Applications, Limitations and Future Directions; Trends in Immunology; 2001; 22(7); 386-393 |
| Egilmez, N.K., Jong, Y.S., Mathiowitz, E., Richard Bankert; Tumor vaccination with cytokine-encapsulated microspheres; Methods in Molecular Medicine; 2001 Jan; |
| Sugano M, Egilmez NK, Yokota SJ, Chen FA, Harding J, Huang SK, Bankert RB; Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and
metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice.; Cancer Res; 2000 Dec; 60(24); 6942-6949 |
| Sugano M, Egilmez NK, Yokota SJ, Chen FA, Harding J, Huang SK, Bankert RB; Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice.; Cancer Res; 2000 Dec; 60(24); 6942-6949 |
| Egilmez NK, Jong YS, Sabel MS, Jacob JS, Mathiowitz E, Bankert RB; In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres:
induction of tumor regression and potent antitumor immunity.; Cancer Res; 2000 Jul; 60(14); 3832-3837 |
| Egilmez NK, Jong YS, Sabel MS, Jacob JS, Mathiowitz E, Bankert RB; In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity.; Cancer Res; 2000 Jul; 60(14); 3832-3837 |
| Sabel MS, Yamada M, Kawaguchi Y, Chen FA, Takita H, Bankert RB; CD40 expression on human lung cancer correlates with metastatic spread.; Cancer Immunol Immunother; 2000 May; 49(2); 101-108 |
| Bankert RB, Chen FA, Sugiyama Y, Egilmez N; Patient immune response to tumors monitored using SCID mouse models.; Immunol Invest; 2000 May; 29(2); 171-176 |
| Egilmez, N.K., Jong, Y.S., Hess, S.D., Jacob, J.S., Mathiowitz, E., Richard Bankert; Cytokines delivered by biodegradable microspheres promote effective suppression of human tumors by human peripheral blood lymphocytes in the SCID-Winn model; J. Immunotherapy; 2000 Jan; 23; 190-195 |
| Conway TF, Sabel MS, Sugano M, Frelinger JG, Egilmez NK, Chen F, Bankert RB; Growth of human tumor xenografts in SCID mice quantified using an immunoassay
for tumor marker protein in serum.; J Immunol Methods; 2000 Jan; 233(1-2); 57-65 |
| Conway TF, Sabel MS, Sugano M, Frelinger JG, Egilmez NK, Chen F, Bankert RB; Growth of human tumor xenografts in SCID mice quantified using an immunoassay for tumor marker protein in serum.; J Immunol Methods; 2000 Jan; 233(1-2); 57-65 |
| Kuriakose MA, Chen FA, Egilmez NK, Jong YS, Mathiowitz E, DeLacure MD, Hicks WL, Loree TL, Bankert RB; Interleukin-12 delivered by biodegradable microspheres promotes the antitumor
activity of human peripheral blood lymphocytes in a human head and neck tumor xenograft/SCID mouse model.; Head Neck; 2000 Jan; 22(1); 57-63 |
| Kuriakose MA, Chen FA, Egilmez NK, Jong YS, Mathiowitz E, DeLacure MD, Hicks WL, Loree TL, Bankert RB; Interleukin-12 delivered by biodegradable microspheres promotes the antitumor activity of human peripheral blood lymphocytes in a human head and neck tumor xenograft/SCID mouse model.; Head Neck; 2000 Jan; 22(1); 57-63 |
| Sabel, M.S., Conway, T.F., Chen, F-A., Richard Bankert; Monoclonal antibodies directed against the T-cell activation molecule CD137 (ILA/4-1BB) block human lymphocyte mediated suppression of tumor xenografts in SCID mice; J. Immunotherapy; 2000 Jan; 23; 362-368 |
| Bankert RB, Chen, F-A, Sugiyama, Y, Egilmez NK; Patient immune response to tumors monitored using SCID mouse models; Immunol. Invest.; 2000; 29(2); 171-176 |
| Mazzaferro, P.K., Richard Bankert; Biochemistry of immunoglobulins; The Clinical Chemistry of Laboratory Animals; 1999 Jan; |
| Jong, Y.S., Egilmez NK, Jacob, J.S., Smith, L.P., Mottl, T.S., Chen, F-A., Bankert RB, Mathiowitz, E.; Evaluation of cytokine delivery systems for cancer immunotherapy; Proc. Mater. Res. Soc., Implants and Tissue Engineering; 1999; 550; 71-75 |
| Egilmez NK, Jong YS, Iwanuma Y, Jacob JS, Santos CA, Chen FA, Mathiowitz E, Bankert RB; Cytokine immunotherapy of cancer with controlled release biodegradable microspheres
in a human tumor xenograft/SCID mouse model.; Cancer Immunol Immunother; 1998 Mar; 46(1); 21-24 |
| Egilmez NK, Jong YS, Iwanuma Y, Jacob JS, Santos CA, Chen FA, Mathiowitz E, Bankert RB; Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.; Cancer Immunol Immunother; 1998 Mar; 46(1); 21-24 |
| Iwanuma Y, Chen FA, Egilmez NK, Takita H, Bankert RB; Antitumor immune response of human peripheral blood lymphocytes coengrafted
with tumor into severe combined immunodeficient mice.; Cancer Res; 1997 Jul; 57(14); 2937-2942 |
| Iwanuma Y, Chen FA, Egilmez NK, Takita H, Bankert RB; Antitumor immune response of human peripheral blood lymphocytes coengrafted with tumor into severe combined immunodeficient mice.; Cancer Res; 1997 Jul; 57(14); 2937-2942 |
| Sakakibara T, Chen FA, Kida H, Kunieda K, Cuenca RE, Martin FJ, Bankert RB; Doxorubicin encapsulated in sterically stabilized liposomes is superior to free drug or drug-containing conventional liposomes at suppressing growth and metastases of human lung tumor xenografts.; Cancer Res; 1996 Aug; 56(16); 3743-3746 |
| Egilmez NK, Cuenca R, Yokota SJ, Sorgi F, Bankert RB; In vivo cytokine gene therapy of human tumor xenografts in SCID mice by liposome-mediated
DNA delivery.; Gene Ther; 1996 Jul; 3(7); 607-614 |
| Egilmez NK, Cuenca R, Yokota SJ, Sorgi F, Bankert RB; In vivo cytokine gene therapy of human tumor xenografts in SCID mice by liposome-mediated DNA delivery.; Gene Ther; 1996 Jul; 3(7); 607-614 |
| Diamond M, Williams SS, Kida H, Yokota S, Bankert RB; VH and VL gene complexes encoding an anti-spectrin antibody are defined by nucleotide sequencing of cDNA from a hybridoma generated from Hu-PBL-SCID mouse.; Immunol Invest; 1996 Jul; 25(4); 291-305 |
| Egilmez NK, Iwanuma Y, Bankert RB; Evaluation and optimization of different cationic liposome formulations for
in vivo gene transfer.; Biochem Biophys Res Commun; 1996 Apr; 221(1); 169-173 |
| Egilmez NK, Iwanuma Y, Bankert RB; Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer.; Biochem Biophys Res Commun; 1996 Apr; 221(1); 169-173 |
| Williams SS, Chen FA, Kida H, Yokata S, Miya K, Kato M, Barcos MP, Wang HQ, Alosco T, Umemoto T, Croy BA, Repasky EA, Bankert RB; Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice.; J Immunol; 1996 Mar; 156(5); 1908-1915 |
| Bumpers HL, Alosco TR, Wang HQ, Petrelli NJ, Hoover EL, Bankert RB; Consistent hepatic metastasis of human colorectal cancer in severe combined immunodeficient mice.; J Surg Res; 1996 Feb; 61(1); 282-288 |
| Sakakibara, T., Xu, Y., Bumpers, H.L., Chen, F-A., Richard Bankert, Arredondo, M.A., Edge, S.B., Repasky, E.A.; Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice; The Cancer Journal from Scientific American; 1996 Jan; 2; 291-300 |
| Cuenca, R.E., Takita, H., Richard Bankert; Orthotopic engraftment of human lung tumors in SCID mice for the study of metastasis; Surg. Oncol.; 1996 Jan; 5; 85-91 |
| Winter DB, Diamond ME, Abu-hadid M, Falkenberg S, Bankert RB; Allelic differences in the VHOx-1 gene explain the absence of a B cell clonal dominance in the primary response of C57BL/6 mice to phthalate.; J Immunol; 1995 Sep; 155(5); 2445-2452 |
| Chen FA, Williams SS, Fanslow WC, Bankert RB; Human antibody response in human peripheral blood leukocyte/severe combined immunodeficient chimeric model is dependent on B and T cell costimulation via CD40/CD40 ligand.; J Immunol; 1995 Sep; 155(6); 2833-2840 |
| Falkenberg S, Winter D, Bankert RB; Transient dominance of the early primary immune response by a highly conserved B-cell clone that is distinguished by its lack of memory, high threshold of activation, and a high affinity.; Cell Immunol; 1995 Jan; 160(1); 123-131 |
| Bumpers HL, Alosco TR, Wang HQ, Petrelli NJ, Hoover EL, Bankert RB; Human villous adenomas engrafted into scid mice survive for prolonged period without malignant transformation.; J Clin Invest; 1994 Nov; 94(5); 2153-2157 |
| Chen FA, Alosco T, Croy BA, Narumi K, Percy DH, Bankert RB; Clones of tumor cells derived from a single primary human lung tumor reveal different patterns of beta 1 integrin expression.; Cell Adhes Commun; 1994 Aug; 2(4); 345-357 |
| Narumi K, Chen FA, Bankert RB, Takita H; Generation of monoclonal antibodies that distinguish between mesotheliomas and other tumor of the lung.; Nippon Geka Hokan; 1994 Jul; 63(4); 129-138 |
| Alosco, T., Gansbacher, B., Richard Bankert, Takita, H., Petrelli, N.; Human lung tumor cell secretion of Interleukin-2 for protection against tumor engraftment; Ann. of Surgical Oncology; 1994 Jan; 1(3); 229-235 |
| Williams SS, Alosco TR, Mayhew E, Lasic DD, Martin FJ, Bankert RB; Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes.; Cancer Res; 1993 Sep; 53(17); 3964-3967 |
| Williams SS, Alosco TR, Croy BA, Bankert RB; The study of human neoplastic disease in severe combined immunodeficient mice.; Lab Anim Sci; 1993 Apr; 43(2); 139-146 |
| Alosco, T., Croy, B.A., Gansbacher, B., Wang, H-Q., Rao, U., Richard Bankert; Antitumor response independent of functional B or T lymphocytes induced by the local and sustained release of interleukin-2 by the tumor cells; Cancer Immunol. Immunotherap.; 1993 Jan; 36; 364-372 |
| Lou SC, Winter D, Mayers GL, Bankert RB; Nucleotide sequence of messenger RNA encoding VHDJH and VKJK of a highly conserved idiotype-defined primary response anti-hapten antibody.; J Immunol; 1992 Dec; 149(12); 3944-3952 |
| Williams SS, Umemoto T, Kida H, Repasky EA, Bankert RB; Engraftment of human peripheral blood leukocytes into severe combined immunodeficient mice results in the long term and dynamic production of human xenoreactive antibodies.; J Immunol; 1992 Oct; 149(8); 2830-2836 |
| Gregorio CC, Kubo RT, Bankert RB, Repasky EA; Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation.; Proc Natl Acad Sci U S A; 1992 Jun; 89(11); 4947-4951 |
| Klein CE, Dressel D, Steinmayer T, Mauch C, Eckes B, Krieg T, Bankert RB, Weber L; Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils.; J Cell Biol; 1991 Dec; 115(5); 1427-1436 |
| Parikh VS, Nakai C, Yokota SJ, Bankert RB, Tucker PW; COOH terminus of membrane IgM is essential for an antigen-specific induction of some but not all early activation events in mature B cells.; J Exp Med; 1991 Nov; 174(5); 1103-1109 |
| Chen FA, Repasky EA, Bankert RB; Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule.; J Exp Med; 1991 May; 173(5); 1111-1119 |
| Ghosh SK, White LM, Ghosh R, Bankert RB; Vaccination with membrane-associated idiotype provides greater and more prolonged protection of animals from tumor challenge than the soluble form of idiotype.; J Immunol; 1990 Jul; 145(1); 365-370 |
| Drake JR, Repasky EA, Bankert RB; Endocytosis of antigen, anti-idiotype, and anti-immunoglobulin antibodies and receptor re-expression by murine B cells.; J Immunol; 1989 Sep; 143(6); 1768-1776 |
| Chen FA, Repasky EA, Takita H, Schepart BS, Bankert RB; Cell surface glycoprotein associated with human lung tumors that is similar to but distinct from the epidermal growth factor receptor.; Cancer Res; 1989 Jul; 49(13); 3642-3649 |
| Sugiyama, Y., Saji, S., Takita, H., Richard Bankert; Application of (125) I-labeled monoclonal antibody to the postoperative adjuvant immunotherapy; Biotherapy; 1989 Jan; 3; 1282-1285 |
| Ghosh SK, Bankert RB; Generation of somatic variants of a B cell hybrid mediated by a non-cytolytic L3T4+ idiotype-specific T cell.; J Immunol; 1989 Jan; 142(2); 409-415 |
| Richard Bankert, Umemoto, T., Sugiyama, Y., Chen, F.A., Repasky, E., Yokota, S.; Human lung tumors, patients' peripheral blood lymphocytes and tumor infiltrating lymphocytes propagated in SCID mice. proc. of the EMBO Workshop on the SCID Mouse, Basell, Switzerland, Feb. 1989; Curr. Topics In Microbiol. and Immunol.; 1989 Jan; 152; 201-210 |
| Bankert RB, Yokota S, Ghosh SK, Mayhew E, Jou YH; Immunospecific targeting of cytosine arabinonucleoside-containing liposomes to the idiotype on the surface of a murine B-cell tumor in vitro and in vivo.; Cancer Res; 1989 Jan; 49(2); 301-308 |
| Sugiyama, Y., Saju, S., Takita, H., Richard Bankert; Therapeutic effect of (125)I-labeled monoclonal antibody on human lung tumor xenografts; Biotherapy; 1989 Jan; 3; 325-328 |
| Lee JK, Black JD, Repasky EA, Kubo RT, Bankert RB; Activation induces a rapid reorganization of spectrin in lymphocytes.; Cell; 1988 Dec; 55(5); 807-816 |
| Abu-Hadid MM, Bankert RB, Mayers GL; Selective elimination of idiotype-binding cells in vivo by a drug-idiotype conjugate demonstrates the functional significance of these cells in immune regulation.; Proc Natl Acad Sci U S A; 1988 Jun; 85(11); 3990-3994 |
| Sugiyama Y, Chen FA, Takita H, Bankert RB; Selective growth inhibition of human lung cancer cell lines bearing a surface glycoprotein gp160 by 125I-labeled anti-gp160 monoclonal antibody.; Cancer Res; 1988 May; 48(10); 2768-2773 |
| Black JD, Koury ST, Bankert RB, Repasky EA; Heterogeneity in lymphocyte spectrin distribution: ultrastructural identification of a new spectrin-rich cytoplasmic structure.; J Cell Biol; 1988 Jan; 106(1); 97-109 |
| Lou, S-C., Richard Bankert; Use of congenic and recombinant inbred mouse strains to link a highly conserved idiotypic marker to an Igh-C region allotype locus and to map this new member of the Q52 gene family within the Igh-V gene complex; H-2 Antigens, Genes and Molecules, Function; 1988 Jan; 144; 801-814 |
| Ghosh SK, Patnaik P, Bankert RB; Expression of mu and gamma 1 membrane forms of immunoglobulin segregate in somatic cell hybrids.; Mol Immunol; 1987 Dec; 24(12); 1335-1343 |
| Abu-hadid MM, Bankert RB, Mayers GL; Antigen-specific drug-targeting used to manipulate an immune response in vivo.; Proc Natl Acad Sci U S A; 1987 Oct; 84(20); 7232-7236 |
| Hughes CS, Repasky EA, Bankert RB, Johnson RJ, Subjeck JR; Effects of hyperthermia on spectrin expression patterns of murine lymphocytes.; Radiat Res; 1987 Oct; 112(1); 116-123 |
| Reddy S, Piccione D, Takita H, Bankert RB; Human lung tumor growth established in the lung and subcutaneous tissue of mice with severe combined immunodeficiency.; Cancer Res; 1987 May; 47(9); 2456-2460 |
| Luo SC, Bankert RB; A new cross-reactive idiotype-defined family in the phthalate humoral immune response of mice. I. Linkage of VH-Xmp to IgCH allotype locus and mapping with respect to other known VH genes.; J Immunol; 1987 Apr; 138(7); 2311-2315 |
| Ghosh SK, Wong J, Bankert RB; Idiotype-specific T lymphocytes responsible for the selection of somatic variants of a B cell hybrid.; J Immunol; 1987 Apr; 138(7); 2230-2235 |
| Mazzaferro, P.K., Repasky, E.A., Black, J., Kubo, R.T., Richard Bankert; Biochemical and ultrastructural characterization of a novel cell structure associated with immunoglobulin secretion of B-lymphocytes; J. Molec. Cell Immunol.; 1987 Jan; 3; 293-306 |
| Richard Bankert, Repasky, E.A., Mazzaferro, P.K., Kubo, R.T.; Generation and use of an antigen-specific hybrid to study B-cell function; J. Mol. Cell. Immunol.; 1987 Jan; 3; 279-291 |
| Zylstra S, Chen FA, Ghosh SK, Repasky EA, Rao U, Takita H, Bankert RB; Membrane-associated glycoprotein (gp 160) identified on human lung tumors by a monoclonal antibody.; Cancer Res; 1986 Dec; 46(12 Pt); 6446-6451 |
| Pauly JL, Bankert RB, Repasky EA; Immunofluorescent patterns of spectrin in lymphocyte cell lines.; J Immunol; 1986 Jan; 136(1); 246-253 |
| Saji, S., Kato, K., Sakata, H., Takita, H., Richard Bankert; The production and the clinical application of monoclonal antibodies against human lung carcinoma; Oncologia; 1986 Jan; 18; 147-157 |
| Schepart BS, Abu-Hadid M, Mayers GL, Bankert RB; Antibody response of BALB/c mice to dextran B1355S: alterations in the expression of an idiotype associated with the depletion of idiotype-binding cells.; J Immunol; 1985 Sep; 135(3); 1690-1697 |
| Schepart BS, Mayers GL, Bankert RB; Failure of PFC inhibition assays to distinguish idiotypically between clonotypes that are readily distinguishable by RIA analysis.; J Immunol; 1985 Sep; 135(3); 1683-1689 |
| Luo SC, Bankert RB; Cross-reactive idiotype family observed in the phthalate-specific B cell repertoire of adult BALB/c mice: diversity of IgM compared with IgG monoclonal anti-phthalate antibodies.; J Immunol; 1985 Aug; 135(2); 1252-1258 |
| Raza, A., Spiridonidis, C., Ucar, K., Mayers, G.L., Richard Bankert, Preisler, H.; Double labelling with anti-Brdu antibody and titrated thymidine; Cancer Research; 1985 Jan; 45; 2283-2287 |
| Lou, S-C., Richard Bankert; Monoclonal antibodies specific for the mouse IgG1 allotype determinants: Reactivity with inbred and outbred mice; J. Immunol.; 1985 Jan; 4; 319-327 |
| Ghosh SK, Bankert RB; Generation of heavy chain-loss mutants in a B cell hybrid mediated by syngeneic idiotype-specific spleen cells.; J Immunol; 1984 Sep; 133(3); 1677-1682 |
| Repasky EA, Symer DE, Bankert RB; Spectrin immunofluorescence distinguishes a population of naturally capped lymphocytes in situ.; J Cell Biol; 1984 Jul; 99(1 Pt); 350-355 |
| Richard Bankert; Development and use of monoclonal antibodies in the treatment of cancer; Cancer Drug Delivery; 1984 Jan; 1; 251-267 |
| Richard Bankert, Mayhew, E., Yokota, S., Jou, Y-H.; Immunospecific tumor targeting of drug containing liposomes; Antibodies, Protective, Destructive and Regulatory Role; 1984 Jan; |
| Saji, S., Zylstra, S., Schepart, B.S., Ghosh, S.K., Jou, Y-H., Takita, H., Richard Bankert; Monoclonal antibodies specific for two different histological types of human lung carcinoma; Hybridoma; 1984 Jan; 3; 119-129 |
| Richard Bankert, Jou, Y-H., Mayers, G.L.; Monoclonal Immunoglobulins derived from myelomas and hybridomas; Molecular Immunology; 1984 Jan; |
| Jou YH, Luo SC, Bankert RB; A filtration double antibody radioimmunoassay that simplifies and semi-automates the isolation of immune precipitates.; J Immunol Methods; 1983 Dec; 65(3); 285-292 |
| Jou, Y-H., Mazzaferro, P.K., Mayers, G.L., Richard Bankert; Methods for the attachment of haptens and proteins to erythrocytes; Methods in Enzymmology; 1983 Jan; 92; 257-276 |
| Richard Bankert; Rapid screening and replica-plating of hybridomas for the production and characterization of monoclonal antibodies; Methods in Enzymmology; 1983 Jan; 92; 182-195 |
| Bloor AG, Jou Y, Hoeplinger C, Gartner JE, Mayers GL, Bankert RB; Hapten-specific B cell repertoire probed by hybridoma technology: selection and characterization of representative clonotypes from the antibody-forming cell pool.; J Immunol; 1982 Mar; 128(3); 1443-1449 |
| Bankert RB, Bloor AG, Jou YH; Idiotypes: their presence on B- and T-lymphocytes and their role in the regulation of the immune response.; Vet Immunol Immunopathol; 1982 Jan; 3(1-2); 147-184 |
| Jou, Y-H., Schepart, B.S., Richard Bankert; Monoclonal antibodies and a heterobifunctional reagent: a novel approach to the vectoral labeling of selected membrane proteins; Immunol. Commun.; 1982 Jan; 11; 357-375 |
| Jou YH, Bankert RB; Coupling of protein antigens to erythrocytes through disulfide bond formation: preparation of stable and sensitive target cells for immune hemolysis.; Proc Natl Acad Sci U S A; 1981 Apr; 78(4); 2493-2496 |
| Richard Bankert, Mazzaferro, D., Mayers, G.L.; Hybridomas producing hemolytic plaques used to study the relationship between monoclonal antibody affinity and the efficiency of plaque inhibition with increasing concentrations of antigen; Hybridoma; 1981 Jan; 1; 47-58 |
| Richard Bankert, Mayers, G. L.; Immune response of BALB/c mice to phthalate: Characterization of a new and useful model for studying immune regulation; Immunol. Commun.; 1981 Jan; 10; 457-481 |
| Bankert RB, DesSoye D, Powers L; Antigen-promoted cell fusion: antigen-coated myeloma cell fuse with antigen-reactive spleen cells.; Transplant Proc; 1980 Sep; 12(3); 443-446 |
| Mayers GL, Bankert RB; Immunochemistry of monoclonal antibodies.; Transplant Proc; 1980 Sep; 12(3); 413-416 |
| Bankert RB, Mayers GL; Use of hybridoma technology to assess the antibody repertoire to a negatively charged hapten.; Transplant Proc; 1980 Sep; 12(3); 409-412 |
| Pressman, D., Richard Bankert; Lymphocyte hibridomas: current and anticipated application in cancer ans transplantation research; J. Sur. Oncology; 1980 Jan; 15; 393 |
| Richard Bankert, Abbas, A.K.; Myelomas as models to study activation and suppression of normal lymphocytes; Progress in Myelomas; 1980 Jan; |
| Richard Bankert, Des Soye, D., Powers, L.; Screening and replica plating of anti-hapten hybridomas with a transfer template hemolytic spot assay; J. Immunol. Methods; 1980 Jan; 35; 23-32 |
| Bankert RB, Mayers GL, Pressman D; Synthesis of a lipopolysaccharide designed to conjugate haptens and proteins to erythrocyte for use as target cells in passive hemagglutination and hemolytic assays.; J Immunol; 1979 Dec; 123(6); 2466-2474 |
| Bankert RB, Mayers GL, Pressman D; Clearance and re-expression of a myeloma cell's antigen-binding receptors induced by ligands known to be immunogenic or tolerogenic for normal B lymphocytes: a model to study membrane events associated with B cell tolerance.; Eur J Immunol; 1978 Jul; 8(7); 512-519 |
| Mayers GL, Bankert RB, Pressman D; Comparison of the homogeneous, primary anti-dextran B1355 antibody raised in BALB/c mice with protein 104E.; J Immunol; 1978 Apr; 120(4); 1143-1148 |
| Bankert RB, Mayers GL, Pressman D; Mechanisms of B cell tolerance. I. Tolerance to dextran B1355 induced with the oxidized dextran.; J Immunol; 1977 Apr; 118(4); 1265-1270 |
| Bankert RB, Wolf B, Pressman D; Antigen-specific receptors on antibody-forming cells expressing light and heavy chain determinants.; Cell Immunol; 1976 Nov; 27(1); 111-120 |
| Bankert RB, Pressman D; Receptor-blocking factor present in immune serum resembling auto-anti-idiotype antibody.; J Immunol; 1976 Aug; 117(2); 457-462 |
| Bankert RB, Wolf B; Rosette-plaque assay: fine specificity differences among individual hapten-primed lymph node cells.; J Immunol; 1974 May; 112(5); 1782-1792 |
| Richard Bankert, Wolf, B.; Fine specificity differences among individual hapten-primed lymph node cells; J. Immunol.; 1974 Jan; 112; 1782-1792 |
| Bankert RB, Wolf B; Simultaneous expression of hapten binding and antibody secretion by NIP-primed lymph node cells early in the immune response.; J Immunol; 1973 Dec; 111(6); 1790-1799 |
| Egilmez NK, Jong YS, Hess SD, Jacob JS, Mathiowitz E, Bankert RB; Cytokines delivered by biodegradable microspheres promote effective suppression
of human tumors by human peripheral blood lymphocytes in the SCID-Winn model.; J Immunother; 23(2); 190-195 |
| Sugiyama Y, Kato M, Chen FA, Williams SS, Kawaguchi Y, Miya K, Jong YS, Mathiowitz E, Egilmez NK, Bankert RB; Human inflammatory cells within the tumor microenvironment of lung tumor xenografts
mediate tumor growth suppression in situ that depends on and is augmented by interleukin-12.; J Immunother; 24(1); 37-45 |
| Egilmez NK, Bankert RB; Liposome-mediated cytokine gene delivery to human tumor xenografts.; Methods Enzymol; 373; 529-535 |
| Abra RM, Bankert RB, Chen F, Egilmez NK, Huang K, Saville R, Slater JL, Sugano M, Yokota SJ; The next generation of liposome delivery systems: recent experience with tumor-targeted,
sterically-stabilized immunoliposomes and active-loading gradients.; J Liposome Res; 12(1-2); 1-3 |
| Egilmez NK, Jong YS, Mathiowitz E, Bankert RB; Tumor vaccination with cytokine-encapsulated microspheres.; Methods Mol Med; 75; 687-696 |
GRANTS
September 2006 to September 2011
Molecules and Cells controlling T Cell Function in Tumors
Sathy Balu-Iyer, Richard Bankert
$6,405,328
|
July 2005 to June 2006
Product Development Fund
University at Buffalo
Sathy Balu-Iyer, Richard Bankert
$33,000
|
January 2001 to January 2006
VHIg Peptide Vaccine Strategies for B-Cell Lymphomas
NIH
Richard Bankert
$150,000
|
January 2000 to December 2002
A Tumor VH Peptide Vaccine for Patients with Non-Hodgkins Lymphoma
NIH
Dr. Bernstein, Richard Bankert
$100,000
|
January 2000 to January 2002
Bioadhesive Microspheres for Colon Cancer Therapy
NIH
Dr. Egilmez, Richard Bankert
$194,000
|
January 2000 to January 2004
VHIg Peptide Vaccines for Human B-Cell Malignancies
NIH
Richard Bankert
$224,784
|
January 1998 to December 2001
Immunology/CTLA4
Pfizer, Inc.
Richard Bankert
$64,000
|
January 1997 to December 2002
Immunity and Immunotherapy of Human Cancer in SCID Mice
NIH
Richard Bankert
$95,750
|
January 1991 to December 2002
Factors Affecting Human Lung Tumor Growth in SCID Mice
NIH
Richard Bankert
$194,866
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