Dr. Arin Bhattacharjee Pharmacology And Toxicology Assistant Professor 102 Farber Hall Buffalo NY, 14214 Phone: (716) 829-2800 Fax: (716) 829-2801 Email: ab68@buffalo.edu View map

OFFICE LOCATIONS

621 Biomedical Research Building Buffalo NY, 14214 Phone: (716) 829-2825, 829-3583 Email: ab68@buffalo.edu

DESCRIPTION OF INTERESTS

Neuronal firing patterns are highly diverse because neurons regulate a wide variety of different behaviors and physiological functions including cognition and memory. Whether a neuron exhibits regular spiking, burst firing, adaptation or high frequency firing will largely be determined by which specific ion channel genes a neuron chooses to express. I am interested in a class of potassium channels that are sensitive to intracellular sodium. There are two members in this family, known as Slack and Slick, and both channel subunits are expressed in many different types of neurons. I am particularly interested in how these channels contribute to the firing patterns of pain-sensing neurons and neurons of the cerebral cortex. Understanding when, where and how these channels are working should provide important information on sensory and cortical processing and will provide insights on nociception, psychiatric disorders such as schizophrenia and bipolar disorder and neurological diseases such as epilepsy.

SPECIALTIES

Ion channel kinetics and structure Ion transport Molecular and Cellular Biology Neurobiology Pathophysiology Regulation of gene expression Signal Transduction

EDUCATION

2005	Postdoctoral Fellow, Pharmacology/Neuroscience Yale University
1999	Doctor of Philosophy, Pharmacology University of South Alabama
1992	Certification, Pharmacology University of Alberta
1991	Bachelor of Science, Biology University of Alberta

PUBLICATIONS

Nuwer MO, Picchione KE, Bhattacharjee A; cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.; Neuropharmacology; 2009 Sep; 57(3); 219-226

Tamsett TJ, Picchione KE, Bhattacharjee A; NAD+ Activates KNa Channels in Dorsal Root Ganglion Neurons.; J Neurosci; 2009 Apr; 29(16); 5127-5134

Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK; The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.; J Neurosci; 2009 Apr; 29(17); 5654-5665

Nanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, El Manira A; Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission.; Proc Natl Acad Sci U S A; 2008 Dec; 105(52); 20941-20946

Brown MR, Kronengold J, Gazula VR, Spilianakis CG, Flavell RA, von Hehn CA, Bhattacharjee A, Kaczmarek LK; Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.; J Physiol; 2008 Nov; 586(Pt 21); 5161-5179

Wallén P, Robertson B, Cangiano L, Löw P, Bhattacharjee A, Kaczmarek LK, Grillner S; Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons.; J Physiol; 2007 Sep;

Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK; Pharmacological activation and inhibition of Slack (Slo2.2) channels.; Neuropharmacology; 2006 Sep; 51(4); 896-906

Song P, Yang Y, Barnes-Davies M, Bhattacharjee A, Hamann M, Forsythe ID, Oliver DL, Kaczmarek LK; Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons.; Nat Neurosci; 2005 Oct; 8(10); 1335-1342

Bhattacharjee A, Kaczmarek LK; For K(+) channels, Na(+) is the new Ca(2+).; Trends Neurosci; 2005 Aug; 28(8); 422-428

Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B; Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels.; Hear Res; 2005 Aug; 206(1-2); 133-145

Bhattacharjee A, von Hehn CA, Mei X, Kaczmarek LK; Localization of the Na(+)-activated K(+) channel Slick in the rat central nervous system.; J Comp Neurol; 2005 Mar; 484(1); 80-92

Zhang Y, Joiner WJ, Bhattacharjee A, Rassendren F, Magoski NS, Kaczmarek LK; The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior.; J Biol Chem; 2004 Dec; 279(50); 52324-52330

Huang L, Bhattacharjee A, Taylor JT, Zhang M, Keyser BM, Marrero L, Li M; [Ca2+]i regulates trafficking of Cav1.3 (alpha1D Ca2+ channel) in insulin-secreting cells.; Am J Physiol Cell Physiol; 2004 Feb; 286(2); 213-221

von Hehn CA, Bhattacharjee A, Kaczmarek LK; Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice.; J Neurosci; 2004 Feb; 24(8); 1936-1940

Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK; Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.; J Neurosci; 2003 Dec; 23(37); 11681-11691

Bhattacharjee A, Gan L, Kaczmarek LK; Localization of the Slack potassium channel in the rat central nervous system.; J Comp Neurol; 2002 Dec; 454(3); 241-254

Goswami T, Bhattacharjee A, Babal P, Searle S, Moore E, Li M, Blackwell JM; Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter.; Biochem J; 2001 Mar; 354(Pt 3); 511-519

Wu S, Zhang M, Vest PA, Bhattacharjee A, Liu L, Li M; A mibefradil metabolite is a potent intracellular blocker of L-type Ca(2+) currents in pancreatic beta-cells.; J Pharmacol Exp Ther; 2000 Mar; 292(3); 939-943

Zhuang H, Bhattacharjee A, Hu F, Zhang M, Goswami T, Wang L, Wu S, Berggren PO, Li M; Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells.; Diabetes; 2000 Jan; 49(1); 59-64

Whitehurst RM, Zhang M, Bhattacharjee A, Li M; Dexamethasone-induced hypertrophy in rat neonatal cardiac myocytes involves an elevated L-type Ca(2+)current.; J Mol Cell Cardiol; 1999 Aug; 31(8); 1551-1558

Wang L, Bhattacharjee A, Zuo Z, Hu F, Honkanen RE, Berggren PO, Li M; A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic beta-cell death.; Endocrinology; 1999 Mar; 140(3); 1200-1204

Bhattacharjee A, Whitehurst RM, Zhang M, Wang L, Li M; T-type calcium channels facilitate insulin secretion by enhancing general excitability in the insulin-secreting beta-cell line, INS-1.; Endocrinology; 1997 Sep; 138(9); 3735-3740

Wang L, Bhattacharjee A, Fu J, Li M; Abnormally expressed low-voltage-activated calcium channels in beta-cells from NOD mice and a related clonal cell line.; Diabetes; 1996 Dec; 45(12); 1678-1683

GRANTS

February 2008 to January 2010 John R. Oishei Foundation John R. Oishei Foundation Arin Bhattacharjee $220,000

January 2006 to December 2008 American Diabetes Association - Junior Faculty Award American Diabetes Association Arin Bhattacharjee $414,000