Dr. Steven Fliesler Ophthalmology Professor, Vice-Chair / Director of Research- Ophthalmology VA Western NY Healthcare System Research Service- Bldg 20, Rm 202 3495 Bailey Avenue Buffalo NY, 14215-1129 Phone: 716-862-6538 Fax: 716-862-6526 Email: fliesler@buffalo.edu View map

OFFICE LOCATIONS

VA Western NY Healthcare System (Buffalo VA) Research Service Bldg 20, Room 202 3495 Bailey Avenue Buffalo NY, 14215-1129 Phone: 716-862-6538 Fax: 716-862-6526 Contact: Gina Campagnolo-Smith (admin assistant) Email: fliesler@buffalo.edu View map

Insurance Accepted Veterans Administration

EDUCATION

1982	Postdoctoral Fellow, lipid metabolism and biochemistry of the retina Baylor College of Medicine
1980	Ph.D., Biochemistry Rice University Phi Lambda Upsilon
1973	B.A., Biochemistry University of California, Berkeley

EXPERTISE

animal models of human retinal degenerations

lipid / membrane biochemistry

PUBLICATIONS

Lintker KB, Kpere-Daibo P, Fliesler SJ, Serfis AB, Fliesler S; A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films.; Chem Phys Lipids; 2009 Sep; 161(1); 22-31

Ding XQ, Harry CS, Umino Y, Matveev AV, Fliesler SJ, Barlow RB, Fliesler S; Impaired Cone Function and Cone Degeneration Resulting from CNGB3 Deficiency: Down-regulation of CNGA3 Biosynthesis as a Potential Mechanism.; Hum Mol Genet; 2009 Sep;

Rodriguez IR, Fliesler SJ, Fliesler S; Photodamage Generates 7-keto- and 7-hydroxycholesterol in the Rat Retina via a Free Radical-mediated Mechanism.; Photochem Photobiol; 2009 Sep; 85(5); 1116-1125

Cai X, Nash Z, Conley SM, Fliesler SJ, Cooper MJ, Naash MI, Fliesler S; A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles.; PLoS One; 2009 Apr; 4(4); 5290-5290

Chakraborty D, Ding XQ, Conley SM, Fliesler SJ, Naash MI, Fliesler S; Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones.; Hum Mol Genet; 2009 Mar; 18(5); 797-808

Kovacs WJ, Tape KN, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL, Fliesler S; Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.; J Biol Chem; 2009 Mar; 284(11); 7232-7245

Boesze-Battaglia K, Damek-Poprawa M, Mitchell DC, Greeley L, Brush RS, Anderson RE, Richards MJ, Fliesler SJ, Fliesler S; Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome.; J Lipid Res; 2008 Jul; 49(7); 1488-1499

Ford DA, Monda JK, Brush RS, Anderson RE, Richards MJ, Fliesler SJ, Fliesler S; Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species.; J Neurochem; 2008 May; 105(3); 1032-1047

Elliott MH, Nash ZA, Takemori N, Fliesler SJ, McClellan ME, Naash MI, Fliesler S; Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks.; J Neurochem; 2008 Jan; 104(2); 336-352

Chakraborty D, Ding XQ, Fliesler SJ, Naash MI, Fliesler S; Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation.; Biochemistry; 2008 Jan; 47(4); 1144-1156

Farjo R, Fliesler SJ, Naash MI, Fliesler S; Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity.; J Comp Neurol; 2007 Oct; 504(6); 619-630

Fliesler SJ, Vaughan DK, Jenewein EC, Richards MJ, Nagel BA, Peachey NS, Fliesler S; Partial rescue of retinal function and sterol steady-state in a rat model of Smith-Lemli-Opitz syndrome.; Pediatr Res; 2007 Mar; 61(3); 273-278

Tserentsoodol N, Gordiyenko NV, Pascual I, Lee JW, Fliesler SJ, Rodriguez IR, Fliesler S; Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors.; Mol Vis; 2006 Oct; 12; 1319-1333

Tserentsoodol N, Sztein J, Campos M, Gordiyenko NV, Fariss RN, Lee JW, Fliesler SJ, Rodriguez IR, Fliesler S; Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process.; Mol Vis; 2006 Oct; 12; 1306-1318

Farjo R, Skaggs JS, Nagel BA, Quiambao AB, Nash ZA, Fliesler SJ, Naash MI, Fliesler S; Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors.; J Cell Biol; 2006 Apr; 173(1); 59-68

Correa-Cerro LS, Wassif CA, Kratz L, Miller GF, Munasinghe JP, Grinberg A, Fliesler SJ, Porter FD, Fliesler S; Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy.; Hum Mol Genet; 2006 Mar; 15(6); 839-851

Vaughan DK, Peachey NS, Richards MJ, Buchan B, Fliesler SJ, Fliesler S; Light-induced exacerbation of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.; Exp Eye Res; 2006 Mar; 82(3); 496-504

Richards MJ, Nagel BA, Fliesler SJ, Fliesler S; Lipid hydroperoxide formation in the retina: correlation with retinal degeneration and light damage in a rat model of Smith-Lemli-Opitz syndrome.; Exp Eye Res; 2006 Mar; 82(3); 538-541

Berring EE, Borrenpohl K, Fliesler SJ, Serfis AB, Fliesler S; A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study.; Chem Phys Lipids; 2005 Jul; 136(1); 1-12

Keller RK, Small M, Fliesler SJ, Fliesler S; Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain.; J Lipid Res; 2004 Oct; 45(10); 1952-1957

Fliesler SJ, Peachey NS, Richards MJ, Nagel BA, Vaughan DK, Fliesler S; Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: electrophysiologic, biochemical, and morphologic features.; Arch Ophthalmol; 2004 Aug; 122(8); 1190-1200

Keller RK, Arnold TP, Fliesler SJ, Fliesler S; Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.; J Lipid Res; 2004 Feb; 45(2); 347-355

Serfis AB, Brancato S, Fliesler SJ, Fliesler S; Comparative behavior of sterols in phosphatidylcholine-sterol monolayer films.; Biochim Biophys Acta; 2001 Apr; 1511(2); 341-348

Tan E, Wang Q, Quiambao AB, Xu X, Qtaishat NM, Peachey NS, Lem J, Fliesler SJ, Pepperberg DR, Naash MI, Al-Ubaidi MR, Fliesler S; The relationship between opsin overexpression and photoreceptor degeneration.; Invest Ophthalmol Vis Sci; 2001 Mar; 42(3); 589-600

Fliesler SJ, Bok D, Fliesler S; Richard W. Young: and the band marched on.; Trends Cell Biol; 1999 Jul; 9(7); 280-283

Fliesler SJ, Boesze-Battaglia K, Paw Z, Keller RK, Albert AD, Fliesler S; Squalene is localized to the plasma membrane in bovine retinal rod outer segments.; Exp Eye Res; 1997 Feb; 64(2); 279-282

Fliesler SJ, Florman R, Keller RK, Fliesler S; Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes.; Exp Eye Res; 1995 Jan; 60(1); 57-69

Pittler SJ, Fliesler SJ, Rapp LM, Fliesler S; Novel morphological changes in rat retina induced by intravitreal injection of lovastatin.; Exp Eye Res; 1992 Jan; 54(1); 149-152

Boesze-Battaglia K, Fliesler SJ, Albert AD, Fliesler S; Relationship of cholesterol content to spatial distribution and age of disc membranes in retinal rod outer segments.; J Biol Chem; 1990 Nov; 265(31); 18867-18870

Fliesler SJ, Basinger SF, Fliesler S; Tunicamycin blocks the incorporation of opsin into retinal rod outer segment membranes.; Proc Natl Acad Sci U S A; 1985 Feb; 82(4); 1116-1120

Fliesler SJ, Tabor GA, Hollyfield JG, Fliesler S; Glycoprotein synthesis in the human retina: localization of the lipid intermediate pathway.; Exp Eye Res; 1984 Aug; 39(2); 153-173

GRANTS

Isoprenoid metabolism in the retina(EY007361) National Eye Institute Steven Fliesler