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Fraser Sim
Pharmacology And Toxicology
119 Farber Hall
3435 Main Street
Buffalo NY, 14214
Phone: 829-2151
Email: fjsim@buffalo.edu
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OFFICE LOCATIONS
EDUCATION
| 2001 |
Ph.D., Neuroscience
University of Cambridge
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EXPERTISE
Neuroscience
The molecular control of cell fate and homeostasis of resident stem and progenitor cells in the human brain. Using a combination of cell-sorting techniques and whole-genome microarray to identify an array of signaling pathways that operate in the specification and induction of glial progenitors. Aim to establish the functional significance of these pathways using pharmacological and molecular techniques in vitro and ultimately with in vivo models of CNS demyelination/remyelination. |
PUBLICATIONS
| Sim FJ, Lang JK, Ali TA, Roy NS, Vates GE, Pilcher WH, Goldman SA; Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation.; Glia; 2008 Jul; 56(9); 954-962 |
| Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M; The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex.; J Neurosci; 2007 Nov; 27(45); 12255-12266 |
| Sim FJ, Keyoung HM, Goldman JE, Kim DK, Jung HW, Roy NS, Goldman SA; Neurocytoma is a tumor of adult neuronal progenitor cells.; J Neurosci; 2006 Nov; 26(48); 12544-12555 |
| Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA, Goldmanm SA; Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation.; Ann Neurol; 2006 May; 59(5); 763-779 |
| Sim FJ, Goldman SA; White matter progenitor cells reside in an oligodendrogenic niche.; Ernst Schering Res Found Workshop; 2005 Jan; (53); 61-81 |
| Ibanez C, Shields SA, El-Etr M, Leonelli E, Magnaghi V, Li WW, Sim FJ, Baulieu EE, Melcangi RC, Schumacher M, Franklin RJ; Steroids and the reversal of age-associated changes in myelination and remyelination.; Prog Neurobiol; 2003 Sep; 71(1); 49-56 |
| Sim FJ, Zhao C, Li WW, Lakatos A, Franklin RJ; Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.; Mol Cell Neurosci; 2002 Aug; 20(4); 669-682 |
| Franklin RJ, Zhao C, Sim FJ; Ageing and CNS remyelination.; Neuroreport; 2002 May; 13(7); 923-928 |
| Sim FJ, Zhao C, Penderis J, Franklin RJ; The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation.; J Neurosci; 2002 Apr; 22(7); 2451-2459 |
| Smith PM, Sim FJ, Barnett SC, Franklin RJ; SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells.; Glia; 2001 Dec; 36(3); 342-353 |
| Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ; Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.; Glia; 2001 Sep; 35(3); 204-212 |
| Sim FJ, Hinks GL, Franklin RJ; The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain.; Neuroscience; 2000 Jan; 100(1); 131-139 |
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